John Lamb Research Articles

SPIKED THROUGH THE HEART: A RARE COMPLICATION OF INFERIOR VENA CAVA (IVC) FILTER PLACEMENT

SPIKED THROUGH THE HEART: A RARE COMPLICATION OF INFERIOR VENA CAVA (IVC) FILTER PLACEMENT

Abstract OT2-19-07: A phase I/Ib trial of the CDK4/6 antagonist ribociclib (RIB) and the HDAC inhibitor belinostat (BEL) in patients with metastatic triple negative breast cancer and recurrent ovarian cancer with response prediction by genomics (CHARGE)

Abstract Background: Cytotoxic chemotherapy is the mainstay of treatment in metastatic triple negative breast cancer (TNBC), a phenotype predictive of poor survival. Similarly, ovarian cancer is the leading cause of death from gynecologic malignancies and shares genomic similarities with TNBC. New treatment paradigms are needed for people with these malignancies. CDK4/6 (CDKi) and histone deacetylase (HDACi) inhibitors are promising treatment approaches in breast cancer though neither has been successfully translated as monotherapy in TNBC. HDACi have single-agent activity against TNBC in vivo, possibly through decreasing epithelial mesenchymal transition, migration, and metastases. CDKi cause cell cycle arrest and tumor regression in TNBC models. HDACi increase inhibitors of cell cycle progression including RB1, CDKN1A, CDKN1C, CDKN2B, and CDKN2D in TNBC in vitro. We hypothesized that HDACi would increase the sensitivity of breast cancer to CDKi. RIB + BEL demonstrated growth inhibition in TNBC cell lines with synergy seen at multiple doses. RIB and BEL are expected to be safe in combination. BEL has no effect on CYP3A4, the main metabolizing enzyme for RIB. Although RIB can inhibit CYP3A4, which partially metabolizes BEL, BEL is primarily metabolized by UGT1A1. Although both drugs can cause myelosuppression, thrombocytopenia occurs more often with BEL and leukopenia with RIB. The primary objective is to assess the maximum tolerated dose of RIB and BEL in combination. Secondary objectives include safety and efficacy. Exploratory objectives include development of a predictive biomarker, exploration of subclonal structure and phenotypic pathway activation through serial biopsies, and efficacy within RB1 mutation status subgroups. We hypothesized that RIB plus BEL will be well-tolerated and demonstrate activity in people with metastatic TNBC or recurrent ovarian cancer. Methods: This open-label, multi-center, phase I study follows a modified 3+3 dose escalation design allowing independent escalation of the dose of each of the agents with a 10 person expansion cohort at the Recommended Phase 2 Dose (RP2D). Dose escalation will be open to patients with TNBC or ovarian cancer and only TNBC will be enrolled at dose expansion. The first cohort uses RIB 200 mg daily and BEL 600 mg/m2 daily on days 1-5 of a 28 day cycle. Tumor is assessed at baseline and every 8 weeks. Biopsies occur at screening and cycle 2 day 15 to establish a predictive biomarker panel that will be validated with future study. Patients ≥ 18 years of age who have measurable and metastatic or unresectable disease are included. Patients previously treated with a CDKi or HDACi are excluded. Additional exclusion criteria include use of valproic acid during the study or within 5 days of the first dose of BEL, prolonged QTc, grade ≥2 unresolved diarrhea, or new or progressive brain metastases. Statistical analysis of safety data will be descriptive. Efficacy will be reported in the study population as well as in RB1 mutation status subgroups. PFS will be estimated using Kaplan-Meier methods. Cox regression will be used to determine if there is a relationship between biomarker predictor and PFS. The estimated duration for accrual is 18 months with patient participation of around 36 months. Enrollment began January 2021 with 2 patients currently enrolled. Clinical Trial registry Number: NCT04315233 Citation Format: Shashank Sama, Kristen Kelley, Christos Vaklavas, Andrea Bild, Kenneth Boucher, John Lamb, Julia Lehman, Philip Moos, Theresa Werner, Adam Cohen. A phase I/Ib trial of the CDK4/6 antagonist ribociclib (RIB) and the HDAC inhibitor belinostat (BEL) in patients with metastatic triple negative breast cancer and recurrent ovarian cancer with response prediction by genomics (CHARGE) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT2-19-07.

Review] Okinawans Reaching Australia

This essay is a review of the monograph 'Okinawans Reaching Australia' by John Lamb (Hesperian Press, 2019).

The Afterlives of the Archons: Gnostic Literalism and Embodied Paranoia in Twenty-First Century Conspiracy Theory

Abstract This article analyzes the reception of the ancient Gnostic archons, or rulers, in contemporary conspiracy theories. In the classical Gnostic myth these nefarious beings rule the cosmos, mold primordial matter into a prison for Adam and Eve, and blind the Elect to their divine nature. These archons send cataclysms to earth and serve as celestial gatekeepers that keep the divine light trapped in their creation. Contemporary conspiracy theorists such as John Lamb Lash, David Icke, and Carol Reimer read the archons not as allegories or metaphors, but as real beings at work in contemporary politics, media and religion. Utilizing Michael Barkun’s concept of “superconspiracies,” this article examines how conspiracists Lash, Icke, and Reimer weave disparate conspiratorial discourses together through the classical Gnostic myth. The article concludes that the vast gulf between the anticosmic and anthropic dualism of the classical myth and the generally pro-cosmic and humanist thrust of modern esoterica leads these authors into paradoxical understands of cosmos, mind and eschatology.

Hardcore education: The case of Sexual Freedom in Denmark

Abstract This article addresses John Lamb’s Sexual Freedom in Denmark (Von Hellen, 1970), an American film that explored the liberalization of censorship in Denmark in the late 1960s while advocating for similar changes in the United States. Lamb used explicit sexual imagery with educational material to promote enlightened attitudes. The film was a box office success and became a popular tool with teachers while paving the way for hardcore movies on American screens.

<i>Not in His Image: Gnostic Vision, Sacred Ecology, and the Future of Belief</i> by John Lamb Lash

<i>Not in His Image: Gnostic Vision, Sacred Ecology, and the Future of Belief</i> by John Lamb Lash

Cybernetics, Management Science, and Technology Policy: The Emergence of "Information Technology" as a Keyword, 1948-1985

In November 1981, British prime minister Margaret Thatcher proclaimed 1982 as Information Technology Year, IT-82. Her government aimed to reinvigorate the country's electronics industry to keep it from falling farther behind the United States and Japan in the booming markets of microelectronics, computers, and telecommunications. To celebrate IT-82, the British government issued an IT stamp and commissioned an IT play and an IT ballet. In writing about these events, science journalist John Lamb attributed the concept of an society to American mathematician Norbert Wiener, the founder of cybernetics. Lamb claimed that the phrase information technology was coined only about two years ago.1 Lamb's attribution of the concept appears accurate: in Cybernetics (1948) and The Human Use of Human Beings (1950), Wiener had written about the coming of a second industrial revolution based on the processing of information in computerized, automated factories. Lamb was wrong about the coinage, however. The term information technology arose in management science in the United States in the 1960s, where it signified computer-based mathematical techniques designed to replace mid-level

Guanxi: A Nesting of Groups

L'article a pour but de decrire les differents liens qui peuvent se creer entre differents groupes. Ceux-ci peuvent se faire lors d'un besoin de protection, le groupe protecteur se faisant payer par des cadeaux. Le tissage de liens par des cadeaux se fait dans l'ensemble de la societe chinoise. Ce sont ces liens qui ont permis a certains groupes de survivre lors de crises. Mais ces liens peuvent aboutir a des organisations mafieuses.

Guanxi: A Nesting of Groups

Guanxi: A Nesting of Groups

Some early Academy personalities

professional accomplishments of the officers and board members who served during the first 10 years of the existence of the American Academy of Dermatology were of the highest order. These men made indelible impressions on those who were young physicians at that time. Howard Fox, the first president, was the son of the great George Henry Fox and was determined to equal or surpass his father's accomplishments. He certainly did this, and his personality and dress were commensurate with a dignified proper New Yorker. He must also have had nerves of steel. One day one of his preceptees mistakenly treated a child with tinea capitis twice in the same day with epilating doses of x-ray. Dr. Fox showed no sign of being worried that the child's hair would regrow, which it did. Earl D. Osborne of Buffalo, New York, the first Secretary for 10 years, was a man of tremendous energy. During the annual meetings he was in perpetual motion, and he exemplified the theory that the best committee is composed of one person who is the chairman. He often said The Academy is my baby, which it was in the early years. How he and Gerry Feeney could have accomplished so much for the Academy with very little extra help nobody will ever know. Martin Van Studdiford was everything one would expect a jovial Louisiana southern gentleman to be. At one meeting we were listening to a lecture by a boring but probably dedicated dermatologist when Van Studdiford turned to me and said, You know that man takes himself and life too seriously. I doubt if he knows how to have any fun. What he needs is a little New Orleans treatment. Those who took the treatment with him never forgot it. Everett S. Lain from Oklahoma City was a large man who looked like the type who would have driven a covered wagon to the West. When his two sons-in-law, Onis Hazel and John Lamb, practiced with him, they treated as many squamous cell carcinomas of the skin as any three men before or since. Dr. Lain was known as pop, and when he laid one of his ham-sized hands on a patient and said Son you are going to be just fine, it was the equivalent of a clergyman with good connections doing the same thing in Oklahoma. Clark W. Finnerud was a master clinician who always liked to tell young dermatologists how he managed his large private practice in Chicago. His first principle was to have new patients pay cash on the barrel for a routine first visit charge before he ever laid eyes on them and thereafter as well. His second principle was to take the money received to the bank himself at lunch time. To avoid writing out prescriptions, he had many different professionally printed ones kept in file boxes in each examining room. Most of these had to be compounded but were not particularly complicated. One day a young fool asked him if when he was in a hurry he ever picked out the wrong prescription from so many in the file boxes, lie answered, Young man, time has taught me that when that happens sometimes they work even better. Paul E. Bechet of New York City (pronounced Bachea) was a very pleasant man who was particularly interested in the lives and accomplishments of early dermatologists in the United States. Without his efforts and publications much of the history of our specialty might have been lost. He would talk about C. J. White, Pifford, Stelwagon, and others as though they were his best friends and even knew about their favorite prescriptions. One person, whom I knew well, began to lose his hair at 24 years of age and reasoned that since Dr. Bechet had a full head of hair and knew about

Taxonomy and Biology of Phagicola nana (Digenea: Heterophyidae)

Phagicola nana is resurrected from synonymy and redescribed based on syntypes from the arctic fox, Alopex lagopus, and adults from an experimental infection in the Virginia opossum, Didelphis virginiana. Natural definitive hosts include the great blue heron, Ardea herodias; least bittern, Ixobrychus exilis; and possibly gannet, Morus bassanus. The Virginia opossum, northern raccoon, laboratory white mouse, Syrian hamster, and domestic chicken serve as experimental definitive hosts. Natural metacercarial infections by P. nana occurred in the largemouth bass (Micropterus salmoides), redear sunfish (Lepomis microlophus), bluegill (L. macrochirus), and orangespotted sunfish (L. humilis) collected in estuarine bayous and rivers of Mississippi, Florida, and Georgia. Metacercariae caused minor histopathological alterations in fish hosts by inducing formation of fibrotic host capsules. They encysted primarily in sites already containing fibroblasts. Phagicola nana may have broad host specificity for piscivorous birds and mammals inhabiting estuarine marshes. Moreover, humans probably may become infected with P. nana by ingesting raw or inadequately prepared centrarchid fishes. Phagicola nana (Ransom, 1920) was originally described from a single specimen of the arctic fox, Alopex lagopus (Linnaeus) (as Vulpes 1.). Cause of the fox's death in 1906 at the National Zoological Park, Washington, D.C., was diagnosed as intense purulent peritonitis and septic metritis. At necropsy, Dr. H. W. Graybill collected specimens of it and P. longa (Ransom, 1920), and Ransom (1920) described them both. Because the fox was born and lived its entire four years at the Park, we assume it acquired both heterophyids from raw fishes fed to it. Metacercariae of P. longa parasitize mullets (Edwards & Overstreet, 1976; Hutton, 1957; Hutton & Sogandares-Bernal, 1958, 1959, 1960; Skinner, 1975), and adults occur at least in Procyon lotor (Linnaeus) and birds along the Atlantic and Gulf of Mexico coasts (Harkema & Miller, 1962, 1964; Hutton & Sogandares-Bernal, 1960; Overstreet, 1978). This paper is the first to report metacercariae of P. nana, a species that we consider distinct from P. angrense (Travassos, 1916). We found metacercariae of P. nana commonly We thank Sybil Hamlet, Historian, National Zoological Park, Smithsonian Institution, Washington, D.C., for providing information concerning the type-host of Phagicola nana and John C. Pearson, University of Queensland, for commenting on the manuscript. Also, Dr. J. Ralph Lichtenfels loaned us type and voucher specimens of heterophyids from the USNM Helminthological Collection; Dr. Jeffrey M. Lotz and Mr. Larry Shults donated heterophyids collected from birds and mammals in Ocean Springs, Mississippi; Dr. Adrian Lawler provided laboratory-reared chickens and collected raccoons and opossums for us; and Ronnie Palmer, Joan Durfee, and John Lamb provided technical assistance. We acknowledge the University of Wisconsin-Eau Claire for providing a Faculty Improvement Grant to WFF. The study was conducted in cooperation with the U.S. Department of Commerce, NOAA, National Marine Fisheries Service, under PL 88-309 Project Nos. 2-382-R and 2-393-R. 2 Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54701,

New York's Radicals and the Coming of Independence

HE British-American skirmishes at Lexington and Concord and the consequent siege of British forces in Boston were responsible for creating a Continental Army and the extralegal political machinery to direct a military defense of individual liberty and freedom. Lexington and Concord also placed new and heavy responsibilities upon Whigs everywhere: manpower had to be mobilized, supplies and money obtained, and time given to the myriad details of war. With the emergence in each colony of a quasi-revolutionary government by the spring of 1775, the older tactics of the Sons of Liberty became obsolete and the radical Whig leaders were put to a severe test. In most cases unprepared by training or experience for anything more than managing newspaper propaganda, mass meetings, and street brawling, their continued usefulness would depend upon their adaptation to the changing times which they had in part created. What happened to these radical leaders, whether they continued to shape the future as they had the past, varied in each colony. The response of New York's radical triumvirate of Isaac Sears, John Lamb, and Alexander McDougall was perhaps uniquely different from developments elsewhere. Identified since 1765 as leaders of New York's Sons of Liberty, Sears, Lamb, and McDougall, merchants of modest fortune and middle age, had an off again-on again personal relationship that was largely determined by their involvement in the rivalry of the Livingston and DeLancey factions for political power in the colony. Coming together under the Livingston banner in late 1769 during New York's political crisis over the Quartering Act, the popular trio was firmly joined in the American defense as the critical year of 1775 opened.1 They soon found themselves,

Evidences of the Effect of Erosion on the Organic Matter and Erodibility of Honeoye Soil1

Agronomy JournalVolume 38, Issue 3 p. 207-217 Article Evidences of the Effect of Erosion on the Organic Matter and Erodibility of Honeoye Soil1 George R. Free, George R. Free Soil Conservationist. The author wishes to acknowledge the guidance given by John Lamb, Jr., in connection with investigational work, and also the assistance given by S. J. Mech and J. W. Roehl. Organic matter in soil samples was determined by E. A. Carleton.Search for more papers by this author George R. Free, George R. Free Soil Conservationist. The author wishes to acknowledge the guidance given by John Lamb, Jr., in connection with investigational work, and also the assistance given by S. J. Mech and J. W. Roehl. Organic matter in soil samples was determined by E. A. Carleton.Search for more papers by this author First published: 01 March 1946 https://doi.org/10.2134/agronj1946.00021962003800030001xCitations: 2 1 Contribution from the Division of Research, Soil Conservation Service, U. S. Dept. of Agriculture, in cooperation with Cornell University Agricultural Experiment Station. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume38, Issue3March 1946Pages 207-217 RelatedInformation

GREGORY JOHN LAMB O'NEILL

Medical Journal of AustraliaVolume 2, Issue 10 p. 200-200b Obituary GREGORY JOHN LAMB O'NEILL First published: September 1943 https://doi.org/10.5694/j.1326-5377.1943.tb88406.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume2, Issue10September 1943Pages 200-200b RelatedInformation

Sir Horace Lamb, 1849-1934

Horace Lamb was born at Stockport, November 29, 1849. His father, John Lamb, was a foreman in a cotton mill, who had gained some distinction by an invention for the improvement of spinning machines. John Lamb died when his son was quite young. His widow married again and shortly afterwards Horace went to live with his mother’s sister, Mrs. Holland. By her he was brought up kindly, but in a severely Puritan manner. However, she valued education, and the boy was sent to the Stockport Grammar School, where he found a wise and kindly head master, the Rev. Charles Hamilton. To his insight and influence Lamb felt that he owed his start in life. Mr. Hamilton was an excellent teacher, both of classics and elementary mathematics, and from him we are told his pupil acquired a passing enthusiasm for the Greek and Latin poets.

The Seattle Water System

Journal AWWAVolume 21, Issue 3 p. 358-366 Article The Seattle Water System† John Lamb, John LambAssistant Superintendent, Water Department, Seattle, Wash.Search for more papers by this author John Lamb, John LambAssistant Superintendent, Water Department, Seattle, Wash.Search for more papers by this author First published: 01 March 1929 https://doi.org/10.1002/j.1551-8833.1929.tb17775.x †Presented before the Pacific Northwest Section meeting, November 17, 1928. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume21, Issue3March 1929Pages 358-366 RelatedInformation

BOOK REVIEW

Book reviewed in this article:THE RUNNING AND MAINTENANCE OF THE MARINE DIESEL ENGINE—by John Lamb, Chief Engineer, British Mercantile Marine; with frontispiece, 7 plates and 218 illustrations. Third Edition, Thoroughly Revised, Greatly Enlarged, Reset.STUDIES IN NAVAL ARCHITECTURE — STRENGTH AND ROLLING—A. M. ROBB, D.Sc. J. B.

The very Rev. John Lamb, D.D., Dean of Ely

The very Rev. John Lamb, D.D., Dean of Ely

Reviews and Notices

Reviews and Notices