This article emphasizes the importance of Small and Medium-Sized Enterprises (SMEs) and large companies in driving economic growth. SMEs are labour-intensive and agile, creating more jobs, while large companies are capital-intensive and rely on technology, having more resources for research and development. In the Gulf Cooperation Council (GCC) region, SMEs contribute significantly to Gross Domestic Product (GDP) and job opportunities, while large companies dominate specific sectors. The research employs a multidisciplinary approach using an extensive literature review to summarize the current literature, highlight the economic impact of SMEs and large companies in GCC, and highlight the importance of large companies in developing local citizens. Policy-makers must consider these differences to integrate these dynamic changes for effective support policies. This study examines the economic impact of SMEs and large companies in the GCC region, providing recommendations to support large businesses. It addresses challenges and opportunities related to employment, household earnings, economic output, and value addition. Promoting the economic impact of SMEs and large companies can lead to sustainable economic growth and development in the GCC region. Also, this article pointed out the importance of large companies and their economic impact in the GCC region; policy recommendations will help the governing bodies in decision-making towards promoting sustainable economic growth.