ABSTRACT Optical and Synthetic Aperture Radar (SAR) remote sensing has a long history of use and reached a good level of maturity in archaeological and cultural heritage applications, yet further advances are viable through the exploitation of novel sensor data and imaging modes, big data and high-performance computing, advanced and automated analysis methods. This paper showcases the main research avenues in this field, with a focus on archaeological prospection and heritage site protection. Six demonstration use-cases with a wealth of heritage asset types (e.g. excavated and still buried archaeological features, standing monuments, natural reserves, burial mounds, paleo-channels) and respective scientific research objectives are presented: the Ostia-Portus area and the wider Province of Rome (Italy), the city of Wuhan and the Jiuzhaigou National Park (China), and the Siberian “Valley of the Kings” (Russia). Input data encompass both archive and newly tasked medium to very high-resolution imagery acquired over the last decade from satellite (e.g. Copernicus Sentinels and ESA Third Party Missions) and aerial (e.g. Unmanned Aerial Vehicles, UAV) platforms, as well as field-based evidence and ground truth, auxiliary topographic data, Digital Elevation Models (DEM), and monitoring data from geodetic campaigns and networks. The novel results achieved for the use-cases contribute to the discussion on the advantages and limitations of optical and SAR-based archaeological and heritage applications aimed to detect buried and sub-surface archaeological assets across rural and semi-vegetated landscapes, identify threats to cultural heritage assets due to ground instability and urban development in large metropolises, and monitor post-disaster impacts in natural reserves.