Abstract The relevance of the problem. Demographic processes are an urgent problem for the Far East and the Khabarovsk Krai. The objective of this study was to examine current trends in reproductive losses in Khabarovsk Krai in comparison with data for the Russian Federation and the Far Eastern Federal District. Material and research methods. The comparative analysis method is used in the article. The source of information was publications in Russian scientific journals and monographs, the data obtained from the official web sites of Rossstat of the Russian Federation and the Khabarovsk Krai, as well as statistical materials published by the Medical Information and Analytical Center of the Ministry of Health of the Khabarovsk Krai for 2019–2022. For the period of preparation of the material, the data of Russia's Rosstat for 2023 on maternal and infant mortality in the official access was not available. Results and discussion. A comparative analysis of maternal, perinatal and infant mortality, as well as stillbirth in the context of federal districts, subjects of the Far Eastern Federal District and the Khabarovsk Krai in 2019–2022 has shown that in all 4 indicators the most disadvantaged in the Russian Federation are the Siberian and Far Eastern Federal Districts, as well as the North-West Federal District (except for the infant mortality rate). In the Far Eastern Federal District, the most disadvantaged subjects in terms of all indicators were the Chukotka Autonomous Okrug, the Jewish Autonomous Oblast and the Trans -Baikal Territory, as well as the Kamchatka Oblast (with the exception of an indicator of stillbirth). The Khabarovsk Krai in all aspects has got the middle position. In the Khabarovsk Krai, special attention is required in terms of stillborn and perinatal mortality of Okhotsk and Nikolaevsky-on-Amur municipal areas. Conclusions. The study of reproductive losses in Khabarovsk Krai allows us to determine the risks and priorities for the development of demographic processes. The analysis has shown that the region took a middle position in terms of maternal, perinatal and infant mortality rates in 2019–2022 compared to data for the Russian Federation and the Far Eastern Federal District. At the same time, during the study period, there was a sharp increase in maternal mortality from 6.93 cases in 2019 to 15.5 cases in 2022 per 100,000 births, which indicates the insufficient effectiveness of health authorities and medical organizations in preventing it.
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