JBI SUMARI Research Articles

Double burden of gestational diabetes and pregnancy-induced hypertension in Ethiopia: A systematic review and meta-analysis of observational studies.

The coexistence of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) amplifies the risk of maternal and perinatal mortality and complications, leading to more severe adverse pregnancy outcomes. This systematic review and meta-analysis aimed to assess the double burden of GDM and PIH (GDM/PIH) among pregnant women in Ethiopia. A comprehensive systematic search was conducted in the databases of PubMed, Cochrane Library, Science Direct, Embase, and Google Scholar, covering studies published up to May 14, 2023. The analysis was carried out using JBI SUMARI and STATA version 17. Subgroup analyses were computed to demonstrate heterogeneity. A sensitivity analysis was performed to examine the impact of a single study on the overall estimate. Publication bias was assessed through inspection of the funnel plot and statistically using Egger's regression test. Of 168 retrieved studies, 15 with a total of 6391 participants were deemed eligible. The pooled prevalence of GDM/PIH co-occurrence among pregnant women in Ethiopia was 3.76% (95% CI; 3.29-4.24). No publication bias was reported, and sensitivity analysis suggested that excluded studies did not significantly alter the pooled prevalence of GDM/PIH co-occurrence. A statistically significant association between GDM and PIH was observed, with pregnant women with GDM being three times more likely to develop PIH compared to those without GDM (OR = 3.44; 95% CI; 2.15-5.53). This systematic review and meta-analysis revealed a high dual burden of GDM and PIH among pregnant women in Ethiopia, with a significant association between the two morbidities. These findings emphasize the critical need for comprehensive antenatal care programs in Ethiopia to adequately address and monitor both GDM and PIH for improved maternal and perinatal health outcomes.

Management of Oral Leukoplakia – A Systematic Umbrella Review of Global Evidence

Objective: To summarize the global evidence related to various interventions for treating Oral Leukoplakia. Introduction: Oral leukoplakia is a common oral potentially malignant lesion that precedes the development of oral cancer. The main aim of any treatment is to prevent the malignant transformation. This umbrella review updates the global evidence of different medicinal treatment available for Oral Leukoplakia. Methods: The databases searched were Cochrane database of systematic reviews, JBI Evidence Synthesis, MEDLINE, Web of Science, Scopus. The key terms used were leukoplakia, oral leukoplakias, Proliferative verrucous leukoplakia, interventions, management, chemoprevention, laser, photodynamic, topical agents. JBI Sumari software was used to screen and appraise the articles along with data extraction and data synthesis. Results: A total of 670 citations were identified through the electronic search. Out of which 61 systematic reviews were recognized. Following removal of duplicates, 47 records were retrieved. The full texts of 13 papers were retrieved for further examination with 9 systematic reviews meeting the inclusion criteria and therefore included in this umbrella review. Study overlap calculation was conducted and pooled results showed that the treatments available for oral leukoplakia has little effect on clinical response and malignant transformation rate. Conclusions: Currently we do not have evidence of a treatment that is preventing oral leukoplakia from converting to oral cancer. Treatments such as vitamin A and beta carotene may be effective in reducing clinical size of oral lesions. More long-term studies are required for surgical management, lasers and photodynamic therapy.

Eyelid dermatitis in patch-tested adult patients: a systematic review with a meta-analysis

Eyelid dermatitis (ED) affects a cosmetically significant area and leads to patients’ distress. Despite ongoing and recent research efforts, ED remains a multidisciplinary problem that needs further characterization. We aimed to evaluate the atopic eyelid dermatitis (AED) frequency in ED patients and to perform their clinical profiling. PubMed databases were searched from 01.01.1980 till 01.02.2024 to PRISMA guidelines using a search strategy: (eyelid OR periorbital OR periocular) AND (dermatitis or eczema). Studies with patch-tested ED patients were included. Proportional meta-analysis was performed using JBI SUMARI software. We included 65 studies across Europe, North America, Asia and Australia, with a total of 21,793 patch-tested ED patients. AED was reported in 27.5% (95% CI 0.177, 0.384) of patch-tested ED patients. Isolated ED was noted in 51.6% (95% CI 0.408, 0.623) of 8453 ED patients with reported lesion distribution, including 430 patients with isolated AED. Our meta-analysis demonstrated that the AED frequency in patch-tested ED patients exceeded the previous estimate of 10%. Isolated AED was noted in adult patients, attending contact allergy clinics. Future studies are needed to elucidate the global prevalence and natural history of isolated AED in adults.

Generative artificial intelligence of things systems, multisensory immersive extended reality technologies, and algorithmic big data simulation and modelling tools in digital twin industrial metaverse

Research background: Multi-modal synthetic data fusion and analysis, simulation and modelling technologies, and virtual environmental and location sensors shape the industrial metaverse. Visual digital twins, smart manufacturing and sensory data mining techniques, 3D digital twin simulation modelling and predictive maintenance tools, big data and mobile location analytics, and cloud-connected and spatial computing devices further immersive virtual spaces, decentralized 3D digital worlds, synthetic reality spaces, and the industrial metaverse. Purpose of the article: We aim to show that big data computing and extended cognitive systems, 3D computer vision-based production and cognitive neuro-engineering technologies, and synthetic data interoperability improve artificial intelligence-based digital twin industrial metaverse and hyper-immersive simulated environments. Geolocation data mining and tracking tools, image processing computational and robot motion algorithms, and digital twin and virtual immersive technologies shape the economic and business management of extended reality environments and the industrial metaverse. Methods: Quality tools: AMSTAR, BIBOT, CASP, Catchii, R package and Shiny app citationchaser, DistillerSR, JBI SUMARI, Litstream, Nested Knowledge, Rayyan, and Systematic Review Accelerator. Search period: April 2024. Search terms: “digital twin industrial metaverse” + “artificial Intelligence of Things systems”, “multisensory immersive extended reality technologies”, and “algorithmic big data simulation and modelling tools”. Selected sources: 114 out of 336. Published research inspected: 2022–2024. PRISMA was the reporting quality assessment tool. Dimensions and VOSviewer were deployed as data visualization tools. Findings & value added: Simulated augmented reality and multi-sensory tracking technologies, explainable artificial intelligence-based decision support and cloud-based robotic cooperation systems, and ambient intelligence and deep learning-based predictive analytics modelling tools are instrumental in augmented reality environments and in the industrial metaverse. The economic and business management of the industrial metaverse necessitates connected enterprise production and big data computing systems, simulation and modelling technologies, and virtual reality-embedded digital twins.

Prevalence and incidence of oral cancer and pre-cancerous lesions in indigenous populations: a systematic review protocol.

This review will determine the prevalence and incidence of oral cancer and pre-cancerous lesions in indigenous populations. There are approximately 476 million indigenous individuals worldwide. Oral cancer affected over 350,000 people globally in 2018, with approximately 80% of cases occurring in the indigenous population. Moreover, the incidence of pre-cancerous lesions is high in this population, accounting for 48.3%. Limited evidence exists regarding the burden of oral cancer among indigenous populations despite research on oral health disparities in this group. Studies on the burden of oral cancer and pre-cancerous lesions in indigenous groups, considering rates, ratios (prevalence or mortality), or survival proportions, will be considered for inclusion. There will be no limitations on study design, language, age, gender, or geography. We will exclude studies that only identify, diagnose, or screen oral cancer and pre-cancerous lesions without mentioning prevalence and incidence. This review will follow the JBI methodology for systematic reviews of prevalence and incidence. Databases to be searched will include MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Central Register of Controlled Trials, Scopus, and Dentistry and Oral Sciences Source (EBSCOhost). ProQuest Dissertations and Theses, OAIster, International Association for Dental Research conference abstracts, Google Scholar, government reports, and cancer registry reports will also be screened for unpublished studies. Two reviewers will independently screen articles, and data will be extracted using a customized form. Narrative data synthesis will be conducted and, where appropriate, meta-analysis will be performed. Methodological quality will be assessed using JBI's critical appraisal tool for prevalence studies. PROSPERO CRD42023402858.

Key performance indicators to inform evaluation of wound care programmes for people with complex wounds: a protocol for systematic review.

The objective of the systematic review is to examine and summarise the available evidence in the literature of the use of key performance indicators (KPIs) to inform evaluation of wound care programmes and services for people with hard-to-heal (complex) wounds. The need for wound care is expected to grow with the continued ageing of the population and the resulting increased development of chronic conditions. This expected increase necessitates improvement of wound care programmes and services and their ability to deliver quality, evidence-based and cost-effective practice. The current literature lacks a systematic assessment of KPIs to inform evaluation of wound care services and programmes across various settings, and how the KPIs are used to improve the quality of wound care and achieve desired outcomes. This protocol sets out how the systemtic review will be undertaken. Primary studies will be screened from databases such as MEDLINE, CINAHL and Scopus, with unpublished studies and grey literature retrieved from Google Scholar and ProQuest Dissertations and Theses. The study titles and abstracts will be screened by two independent reviewers, using Covidence systematic review software to ensure they meet the inclusion criteria, who will then proceed with data extraction of the full-text using the standardised data extraction instrument. The reference lists of all studies selected for critical appraisal will be screened for additional publications. The two independent reviewers will critically appraise all studies undergoing full-text data extraction using the appropriate checklist from JBI SUMARI. At all stages, differences between reviewers will be resolved through discussion, with adjudication by a third, independent reviewer. Data points will be analysed with descriptive statistics and grouped, based on programme characteristics and publication status. Grey literature and peer-reviewed publications will form separate analyses. To answer review questions, the data will be summarised in a narrative format. A meta-analysis is not planned. At the time of writing, this protocol has been implemented up to the preliminary literature search. This review will address a current literature gap and systematically identify KPIs in wound care, allowing for programmes to evaluate their quality of care and improve their services in a methodical manner.

Nurses’ experiences of caring for COVID-19 patients: A systematic review of qualitative studies

Background & Aim: Nurses are considered one of the most important members of the healthcare system in facing pandemics, including COVID-19. This study was conducted to explain the nurses' experiences in caring for patients diagnosed with COVID-19. Methods & Materials: This study was a qualitative systematic review. A structured search was conducted using CINAHL, MEDLINE, EMBASE, Pub Med, Google Scholar, Cochrane Library, MedNar, and ProQuest. All qualitative studies describing nurses’ experiences of caring for patients with Covid-19 were included. This review was conducted using the Joanna Briggs Institute methodology for systematic reviews. Themes and narrative statements were extracted from included papers using the JBI SUMARI data extraction tool. Results: The findings of 46 qualitative studies were included in this systematic review. From the data analysis, four themes "Professional Development", "Psychological exhaustion", "Care Challenges" and "Work-family conflict" were extracted. Conclusion: Nurses have experienced conflicts between their work and family and challenges when caring for patients with COVID-19. Hence, they were psychologically under pressure but professionally developed. To ensure the survival of nurses in critical situations, all their needs must be carefully monitored and the necessary support provided to them.

Effectiveness of Individual-Based Strategies to Reduce Nurse Burnout: An Umbrella Review

Aims. This umbrella review aims to comprehensively synthesize and analyze the findings of available systematic reviews on the effectiveness of individual-based strategies for reducing nurse burnout occurring in hospital-based settings. Methods. Following JBI guidelines, an umbrella review was conducted to integrate the effectiveness of various strategies to reduce burnout. Systematic reviews were searched in the Embase, MEDLINE (Ovid), Cochrane Library, CINAHL (EBSCO), Scopus, and WOS databases. Inclusion criteria included studies published in any language from database inception to April 2023. Eligibility assessment involved two independent reviewers who evaluated titles, abstracts, and full texts. The systematic reviews were critically evaluated using JBI SUMARI. The results were narratively synthesized and grouped by strategy. Results. Eleven systematic reviews were included, covering the years 2012 to 2021. The appraisal tools varied, though all included reviews were of high quality. The strategies were categorized into three domains: mental health (51%), physical activities (26%), and professional competence (13%). The interventions most identified were mindfulness-based stress reduction for mental health, yoga for physical activities, and professional competence education. These individual-based strategies were shown to effectively eliminate emotional exhaustion (72.7%), depersonalization (44%), and occupational stress (78%) among nurses in hospital-based settings. Conclusion. Mental health, physical activities, and professional competence are strategies to reduce nurse burnout. Implementing these approaches in healthcare settings can improve emotional exhaustion, depersonalization, and occupational stress of nurses.

Digital interventions for healthy ageing and cognitive health in older adults: a systematic review of mixed method studies and meta-analysis

BackgroundCurrently, there is no systematic review to investigate the effectiveness of digital interventions for healthy ageing and cognitive health of older adults. This study aimed to conduct a systematic review to evaluate the effectiveness of digital intervention studies for facilitating healthy ageing and cognitive health and further identify the considerations of its application to older adults.MethodsA systematic review and meta-analysis of literature were conducted across CINAHL, Medline, ProQuest, Cochrane, Scopus, and PubMed databases following the PRISMA guideline. All included studies were appraised using the Mixed Methods Appraisal Tool Checklist by independent reviewers. Meta-analyses were performed using JBI SUMARI software to compare quantitative studies. Thematic analyses were used for qualitative studies and synthesised into the emerging themes.ResultsThirteen studies were included. Quantitative results showed no statistically significant pooled effect between health knowledge and healthy behaviour (I2 =76, p=0.436, 95% CI [-0.32,0.74]), and between cardiovascular-related health risks and care dependency I2=0, p=0.426, 95% CI [0.90,1.29]). However, a statistically significant cognitive function preservation was found in older adults who had long-term use of laptop/cellphone devices and had engaged in the computer-based physical activity program (I2=0, p<0.001, 95% CI [0.01, 0.21]). Qualitative themes for the considerations of digital application to older adults were digital engagement, communication, independence, human connection, privacy, and cost.ConclusionsDigital interventions used in older adults to facilitate healthy ageing were not always effective. Health knowledge improvement does not necessarily result in health risk reduction in that knowledge translation is key. Factors influencing knowledge translation (i.e., digital engagement, human coaching etc) were identified to determine the intervention effects. However, using digital devices appeared beneficial to maintain older adults’ cognitive functions in the longer term. Therefore, the review findings suggest that the expanded meaning of a person-centred concept (i.e., from social, environmental, and healthcare system aspects) should be pursued in future practice. Privacy and cost concerns of technologies need ongoing scrutiny from policy bodies. Future research looking into the respective health benefits can provide more understanding of the current digital intervention applied to older adults.Study registrationPROSPERO record ID: CRD42023400707 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=400707.

Nursing strategies in antimicrobial stewardship in the hospital environment: a qualitative systematic review

BackgroundAntimicrobial resistance has become one of the world’s most important public health problems. Accordingly, nursing strategies to manage antimicrobials in hospital environments are fundamental to promoting patient health. The aim of this study was to summarise the best evidence available on nursing strategies for the safe management of antimicrobials in hospital environments.MethodsThis qualitative systematic review used meta-aggregation in accordance with the recommendations of the Joanna Briggs Institute. The protocol was registered in the data base of the Prospective Register of Systematic Reviews under No. CRD42021224804. The literature search was conducted, in April and May 2021, in the following data bases and journal repositories: Latin American and Caribbean Health Sciences Literature (LILACS) via the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System on-line (Medline) via PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scientific Electronic Library Online (SciELO) and Excerpta Medica Database (EMBASE). The findings of each study were summarized and the results were meta-aggregated in JBI SUMARI software.ResultsThe search resulted in a total of 447 studies and, after selection, the review included 26 studies, in which 42 nursing strategies were identified. The strategies were first categorised as care- or stewardship-related and then into the subcategories: Screening, Administration, Monitoring and Discharge, Nursing Team, Multi-professional Teams, Patients and Institutional Leadership. The 42 strategies were meta-aggregated and represented in flow diagrams. The best evidence was synthesized related to nursing strategies in the safe management of antimicrobials in the hospital environment.ConclusionsNurses play an indispensable function in antimicrobial stewardship in the hospital environment, because they work directly at the core of safe patient care. Significant contributions by nursing towards reducing antimicrobial resistance were found in care-related practice, education activities, research and policy.

Hidden hunger in patients with type 2 diabetes (T2D) and its effect on glycaemic control: a protocol for systematic review and meta-analysis

IntroductionHidden hunger or micronutrient deficiencies are quite common in many parts of the world, particularly in the countries of sub-Saharan Africa and South Asia. Micronutrient deficiencies may impact insulin signalling...

Does Intrauterine Exposure to Diabetes Impact Mental and Motor Skills? A Meta-Analysis of the Bayley Scales of Infant Development.

Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using I2. Seven studies were identified. The pooled results on psychomotor and mental development index mean scores were lower for infants born to mothers with diabetes than for the control group (Cohen's d = -4.49, df = 7, I2 = 0%, p = 0.001 and Cohen's d = -3.4, df = 9, I2 = 27%, p = 0.001, respectively). Effects were larger in infants born to mothers with type 1 and 2 diabetes and at age 12 months. Maternal diabetes should be considered as a risk factor for children's development, mainly when born to mothers with pre-existing diabetes.

Patient and Provider Perspectives on Barriers and Facilitators to the Acceptance of Pain Neuroscience Education in Chronic Musculoskeletal Pain Conditions: A Qualitative Systematic Review Protocol

Objective: To identify and map barriers and facilitators to the acceptance of pain neuroscience education for chronic musculoskeletal pain conditions. Introduction: Pain neuroscience education aims to reconceptualize the understanding of the biology of pain. This includes the acknowledgment of physiological and psychological processes relevant to pain experiences to ultimately change maladaptive beliefs and behaviors. Pain neuroscience education in chronic musculoskeletal pain conditions has been demonstrated to positively influence relevant treatment outcomes. Inclusion criteria: Only qualitative studies will be included. The population will include patients with chronic musculoskeletal pain and healthcare providers involved in pain management. The phenomenon of interest encompasses educational interventions on the biology and psychology of pain, which aim to reconceptualize patients’ understanding of pain. Methods: A comprehensive search strategy will be conducted on MEDLINE (PubMed), Web of Science, PsycInfo, and CINHAL. Two reviewers will independently conduct the study selection process, critical appraisal, data extraction, and data synthesis. Discrepancies will be resolved by a third reviewer. The assessment of methodological quality will be guided by JBI’s critical appraisal checklist for qualitative research. Qualitative data synthesis will follow the JBI SUMARI meta-aggregation approach. Considerations of the certainty in the results will be reported in accordance with a ConQual Summary of Findings.

Combined Oral Contraceptives (COCs) Management on symptoms of Polycystic Ovary Syndrom: A Systematic Review

Polycystic Ovary Syndrom (PCOS) has been proved could affect the health of reproductive-aged patients from the physically and emotionally, becoming a major concern of international public health. Meanwhile, PCOS is considered as associated with various severe symptoms, among which infertility is the most of those. The literature argues combined oral contraceptives (COCs) are the first-line treatment modality for PCOS. However, the link between COCs and the symptoms management of PCOS should be bridged. Purpose: This study aims to conduct a systematic review to evaluate the impact of intaking COCs on the management of all relevant symptoms. Method: This review will adhere to the JBI SUMARI guidelines for systematic reviews, and the search method is built to give access to both published and unpublished research. For searching recently released publications, databases like CINAHL plus (EBSCOhost), PubMed, Ovid Emcare, Ovid MEDLINE, and Scopus (Elsevier) are available. Quantitative studies published in English within the last 10 years are intended to be included in the system review. Outcomes: The outcome will present a clear proof between COCs treatment and PCOS symptoms management, including hirsutism, acne, menstrual irregularity and infertility. It could be as the evidence for surgical nurse provide further interventions, which are more tailored and effective, for specific PCOS patients.

Interventions to prevent or manage workplace violence against student nurses during clinical placement: a systematic review protocol.

The objective of this review is to investigate the effectiveness of workplace violence management or prevention interventions, including strategies, protocols, and policies, to address violence against, and provide support to, registered nursing students (RNS) following incidents of violence during clinical placement. Workplace violence is a global issue that affects victims' physical and mental health. RNS are especially vulnerable to workplace violence because of their limited work experience and confidence. These students often feel shocked and unprepared when experiencing workplace violence due to limited education and support provided by educational institutions or clinical sites. Workplace violence can lead to anxiety, decreased confidence, and professional attrition. There is a need to systematically synthesize the evidence on workplace violence management and prevention to support nursing students during clinical placement. The review will consider studies assessing the effectiveness of interventions to address workplace violence or improve support for RNS. Studies that report on educational interventions or pre-clinical placement strategies and measure the preparedness of students will also be considered. Study designs will be limited to quantitative methods that evaluate intervention effectiveness. Databases to be searched include MEDLINE (Ovid), CINAHL (EBSCOhost), Web of Science Core Collection, Scopus, Embase (Ovid), Cochrane Central, ERIC (ProQuest), ProQuest Central, ProQuest Social Science Premium Collection, and ProQuest Dissertations and Theses Global. Two independent reviewers will screen, review, appraise, and extract data from eligible articles. For data synthesis, studies will be pooled using JBI SUMARI. The GRADE approach for grading the certainty of evidence will be followed and a Summary of Findings will be created. PROSPERO CRD42022377318.

Service guidelines, models, and protocols for integrating rehabilitation services in primary healthcare in Brazil, Russia, India, China, and South Africa: a scoping review

Purpose The WHO emphasises that rehabilitation services must be integrated into primary healthcare as an inherent part of universal health coverage. However, there is limited research on the integration of rehabilitation services in primary healthcare in low- and middle-income countries. The purpose of this paper is to identify and describe the literature on service guidelines, models, and protocols that support the integration of rehabilitation services in primary healthcare in the BRICS countries (Brazil, Russia, India, China, and South Africa). Methods A scoping review guided by Arksey and O’Malley’s framework was conducted. Structured database and website searches identified published and unpublished records from 2010, which were subjected to eligibility criteria. Mendeley, JBI SUMARI, and Microsoft Excel were used to extract and synthesise the data. Results The search strategy identified 542 records. Thirty-two records met the inclusion criteria. Shared care and community-based rehabilitation were the most reported practice models, and the implementation of the models, guidelines, and protocols was mostly described in mental health services. Conclusion This review discusses BRICS countries’ rehabilitation service guidelines, models, and protocols for primary healthcare integration and implementation challenges. Rehabilitation professionals should rethink, realign, and apply existing models because of the lack of primary healthcare integration directives.

OP54 Experiences With Out-Of-Hospital Drug Treatment For Systemic Lupus Erythematosus: A Thematic Synthesis

IntroductionSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects quality of life and sometimes requires the use of multiple drugs. Therefore, it is relevant to address the experiences of patients, family members, and caregivers in relation to out-of-hospital SLE drug treatment. This paper presents the results of a pilot project of a Qualitative Evidence Synthesis (QES) conducted by the National Committee for Health Technology Incorporation (Conitec) in the Brazilian public health system.MethodsFor this thematic synthesis, a structured search was conducted in the MEDLINE, CINAHL, and LILACS databases. Seventeen articles were included, and their quality was evaluated using the Critical Appraisal Skills Program criteria. Article content, which was extracted into a spreadsheet adapted from JBI SUMARI, underwent thematic content analysis. Confidence in the findings was evaluated using the GRADE Confidence in the Evidence from Reviews of Qualitative Research tool.ResultsFifteen findings related to three central themes: self-image and appearance; SLE as a chronic disease (disease oscillation, recurrence of symptoms, fear of organ damage, expectation of cure or modification of the disease course, and frequency of medical appointments); and experience with drug therapy (belief in the need for drugs, skepticism, chronicity of treatment, financial difficulty, adverse effects as obstacles to adherence and a source of suffering, efficacy/effectiveness, large quantity and frequency of drugs, and multiple therapeutic attempts).ConclusionsThe findings suggest that patients, family members, and caregivers have an ambivalent relationship with drug treatment. Even though they believe in the effectiveness of the drugs, they also distrust the need to keep using them, especially when SLE is controlled. The improvement of cosmetic manifestations and adverse effects also seem to be important outcomes. Furthermore, the high occurrence of adverse effects and the daily use of many drugs can make treatment adherence harder. In any case, there is an expectation of cure or more significant impact on the course of the disease through pharmacotherapy.

Experienced barriers in the use of ICT for social interaction in older adults ageing in place: a qualitative systematic review protocol (SYSR-D-22–00848)

BackgroundSeveral information and communication technologies (ICT) have been developed to enhance social connectedness of older adults aging in place, although they are not accessible for all. Barriers in using ICT might for example relate to health issues, sensory loss, lack of technical skills, or reluctance to use technologies. Though knowledge on these barriers is crucial for the development and implementation of ICT for older adults, no systematic review was found on this subject. The proposed qualitative systematic review aims to explore barriers experienced by older adults aging in place in using ICT for social interaction.MethodsThe review will be conducted in accordance with the JBI methodology. Databases for search will include MEDLINE (via PubMed), CINAHL (via EBSCO), and Web of Science (ISI), among others. Included studies focus on older adults ageing in place 60 years or older. Pairs of authors will independently, by following agreed guidelines, assess the eligibility of studies, and extract data. The testing of eligibility criteria and screening of titles, abstracts, and full texts will be performed. The findings will describe for example populations, context, culture, and the phenomena of interest. Qualitative research findings will, where possible, be pooled by using JBI SUMARI for the meta-aggregation approach.DiscussionThe mapping of published studies has the potential to identify research gaps in the existing literature, which again may inform developers and stakeholders in designing more user-friendly and adaptive ICT solutions for older people ageing in place.Systematic review registrationCRD42022370044.

'Experiences of patients and their informal caregivers with cognitive stimulation programs for dementia: A qualitative systematic review protocol'.

Cognitive stimulation, an individual or group intervention approach aiming to improve cognitive and social functioning among individuals with mild-to-moderate dementia, is often considered a complex intervention. The patient's experience of a complex intervention is unique and often determines its effectiveness. This proposed qualitative systematic review aims to comprehensively synthesise the experiences of individuals with dementia and their informal caregivers who have participated in cognitive stimulation programs, identifying perceived benefits, challenges, barriers, and facilitators to this approach to intervention. This review will consider qualitative studies that evaluate the experiences of individuals with a diagnosis of dementia and/or the informal caregivers of individuals with dementia who have participated in a cognitive stimulation program. Searches will be conducted across MEDLINE (Ovid), Embase (Elsevier), PsycINFO, Scopus, CINAHL (EBSCO) and Web of Science. Quality of eligible studies will be assessed using the JBI Critical Appraisal Checklist for Qualitative Research, and a standardised data extraction tool in JBI SUMARI will be used to extract data from relevant studies. The meta-aggregation approach will be used to pool qualitative research findings, which will then be synthesised to produce a single set of findings in narrative format. This qualitative systematic review will identify and synthesise the evidence regarding the experiences of individuals with dementia who have taken part in a cognitive stimulation program and the experience of their informal caregivers. As a variety of cognitive stimulation programs exist, our findings will summarise the experiences of these interventions to inform the future development and delivery of cognitive stimulation programs. PROSPERO registration number: CRD42022383658.

A Systematic Review Study by Comparing the Effects of Leucoreduction of Blood Components Using Pre-Storage Filters and Post-Storage Filters on Clinical Outcomes

Background: Transfusion therapy is an effective treatment method but comes with inherent risks such as transfusion reactions, infection transmission, alloimmunization, and platelet refractoriness. Leukocyte reduction, achieved through apheresis or pre- or post-storage filtration, aims to mitigate these risks and potentially reduce the need for antibiotics and hospital stays.&#x0D; Methods: To conduct this systematic review, comprehensive searches were performed using databases such as MEDLINE (PubMed), CINAHL (EBSCO), PsycINFO, Scopus, The Cochrane Library, Web of Science Core Collection, Embase, and LILACS. Grey literature sources were also utilized. Two independent reviewers screened titles and abstracts, and critical appraisal of selected papers was conducted using JBI tools. Relevant data for the review question was extracted using JBI SUMARI. If feasible, a risk analysis of publication bias, meta-analysis, and narrative synthesis were performed.&#x0D; Results: The results of the systematic review will provide insights into the comparative effectiveness of post-storage filters and pre-storage filters in leukocyte reduction during transfusion. Clinical outcomes such as transfusion reactions, bacterial infection, length of hospital stay, and mortality will be assessed. Meta-analyses and narrative synthesis will be utilized to present the findings. The certainty of evidence will be evaluated using the GRADE approach, and a Summary of Findings will be provided, including absolute risks for the pre-storage filter group and the post-storage filter group.&#x0D; Conclusion: This systematic review aims to inform clinical decision-making and guide future research in transfusion medicine. By analyzing methodologically sound studies and employing appropriate meta-analyses, the review will identify the optimal approach for reducing transfusion-related complications and improving patient outcomes. The results will be disseminated through publication in a peer-reviewed journal and presented at conferences and professional meetings.&#x0D; Keywords: Clinical outcomes, leukocyte reduction, post-storage filter, pre-storage filter, transfusion.