Janus Face Research Articles

The Janus Face of Morality & the Two Roots of Moral Foundations

Purpose: The intrinsic dynamics of altruism have not been adequately addressed in the morality literature. This study reduces the gap by constructing a framework, in the triangle of self, sacrifice and morality. Theoretical Framework: Regular meditative processes accompanied by a mantra, increases the value projection capacity of the self, and therefore increases the value attributed to human and transcendent conceptions; while liberals and conservatives project different levels of value on these conceptions in the first place. As a result of the increase, sensitivity to the difference between things that happen and (moral) things that should happen increases and attempts to bridge this gap, often require altruism. Method: To test this framework, altruism level of 230 subjects towards 'human' and 'transcendent conceptions' (THCS) was measured and associated with the MFQ, and the frequency of transcendental meditative experiences of the same sample was questioned. Results and Discussion: While sacrifice towards human was equally correlated with five foundations of the MFQ, sacrifice towards transcendent conceptions correlated at a higher level with only the binding foundations. It was also observed that those who conduct transandantal-meditative states via various rituals, and especially those who experienced ‘awe’ during these processes, achieved significantly higher scores on both the THCS and the MFQ as a whole. Finally, the morality literature was assessed with the help of the current theoretical framework. Research Implications: It seems that ancient rituals are powerful tools for the establishment of morality. Orginality: The relationship between morality and ‘religious ritual induced awe’ has been questioned statistically for the first time through the MFQ.

Flexible plasmonic display featuring differentiated and localized control over transmission and reflection

Structural colors using metal materials, plasmonic color generation, can confine optical excitation beyond the diffraction limit owing to nanoscale metals with high efficiency in light absorption and scattering. They have several advantages over conventional display technology, including superior resolution and long-term preservation. However, most research on plasmonic color generation has been conducted for the development of static color generation, and dynamic tuning remains a challenging issue. To develop dynamic plasmonic colors, electrochemical, liquid crystal, and electromechanical methods have been proposed; however, there have been limitations in repeatability, flexibility, and scale-up processes. To address these problems, this work proposes a flexible dynamic plasmonic display using dielectric elastomer actuators (DEAs) to isotropically control the interdistance between the metal nanostructures, which can show dynamic coloration without polarization distortion. To replace the expensive and small-scale manufacturing approach, shadow masking and transfer technique with the anodic aluminum oxide (AAO) membrane was applied to realize large-scale and uniformly distributed Au nanodisc array. The differentiated and localized color change in the transmission and reflection modes, such as Janus's face, is realized by proper design of Au nanodisc array on the patterned transparent compliant electrodes formed by silver nanowires and PEDOT:PSS composites. Apparent and locally active color changes appeared in the transmission mode, but almost no color changes were observed in the reflection model by DEA actuation. The proposed system has the potential to activate color filters, cryptographic characters, and next generation display technologies.

The Face of the Future: An Affective Mental Time Traveler in Saul Bellow’s “A Father-to-Be”

ABSTRACT This article focuses on a future-oriented Janus face portrayed in Saul Bellow’s short story “A Father-to-Be,” arguing that it builds an exceptional prospective fictional mind in Bellow’s writing with a great emphasis on emotion. Drawing on the “Janus hypothesis,” the article examines how the protagonist’s emotional and imaginative mind interprets the past and processes the present based on a gloomy anticipation of the future, while some previous literary studies on the memory-imagination cognition emphasize the imaginativeness of memory. Affective narratology is largely involved as the supportive explanatory framework in the analysis of the narrative style. The authors approach the structure of the entire story by regarding it as an emotion story and attempt to reveal the aesthetic value of its core narrative by taking emotion both as the force of character forming and as rhetoric.

Fuse and fracture? The janus face of proactive personality in ostracism

AbstractDespite the well identified personality-related factors that drive ostracism, the dual role that a proactive personality plays in influencing ostracism has received little scholarly attention. Drawing on social exchange and social comparison theories, we develop a social relational model of peers’ reactions to a focal proactive member. Findings reveal that a focal member’s proactive personality not only enhances peers’ cognition-based trust in the focal person, but also triggers peers’ feeling of relative deprivation. The peers’ cognition-based trust, in turn, weakens—whereas the feeling of relative deprivation strengthens—peers’ ostracism of the focal proactive member. The focal member’s prosocial motive and proself motive further moderate these relationships. Specifically, prosocial motive strengthens the negative indirect relationship between a focal person’s proactive personality and peers’ ostracism through peers’ cognition-based trust in the focal person. Moreover, proself motive amplifies the positive indirect relationship between a focal person’s proactive personality and peers’ ostracism through peers’ feeling of relative deprivation.

The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons

Recombinant tissue-type plasminogen activator (r-tPA/Actilyse) stands as the prevailing pharmacological solution for treating ischemic stroke patients, of whom because their endogenous circulating tPA alone is not sufficient to rescue reperfusion and to promote favorable outcome. Beyond the tPA contributed by circulating endothelial cells and hepatocytes, neurons also express tPA, sparking debates regarding its impact on neuronal fate ranging from pro-survival to neurotoxic properties. In order to investigate the role of neuronal tPA during brain injuries, we developed models leading to its conditional deletion in neurons, employing AAV9-pPlat-GFP and AAV9-pPlat-Cre-GFP along with tPA floxed mice. These models were subjected to N-methyl-D-aspartate (NMDA)-induced excitotoxicity or thromboembolic ischemic stroke in mice. Initially, we established that our AAV9 constructs selectively transduce neurons, bypassing other brain cell types. Subsequently, we demonstrated that tPA-expressing neurons exhibit greater resistance against NMDA-induced excitotoxicity compared to tPA negative neurons. The targeted removal of tPA in neurons heightened the susceptibility of these neurons to cell death and prevented a paracrine neurotoxic effect on tPA non-expressing neurons. Under ischemic conditions, the self-neuroprotective influence of tPA encompassed both excitatory (GFP+/Tbr1+) and inhibitory (GFP+/GABA+) neurons. Our data indicate that endogenous neuronal tPA is a protective or deleterious factor against neuronal death in an excitotoxic/ischemic context, depending on whether it acts as an autocrine or a paracrine mediator.

Living the Janus Face: The Promise and Perils of Role‐Distancing for Middle Managers

AbstractMiddle managers often find themselves in a challenging position: They have to impress different audiences in somewhat incompatible ways and represent and enact managerial ideals and expectations that may be detrimental to their work identities. This study explores role distancing as an alluring coping strategy. Role distancing – acts that express separateness between the individual and the enacted role – may enable the professional to do management and give an impressive managerial performance, without becoming a manager. This may seem like the perfect strategy to impress others while escaping identity struggles. Or maybe not. In this study we take a closer look at role distancing among a group of middle managers in higher education and focus on one manager, Manny, in particular over a period of time. We find that what first seemed to be a promising strategy applauded by a backstage audience, turns into a problem in need of its own solution, as backstage also becomes a frontstage. The paper contributes to theory about middle managers, role distancing in professional work and front−/backstage acting.

The Janus Face of Cosmopolitics in advance

Scholars in multispecies ethnography, the ontological turn, new materialisms, science and technology studies (STS), assemblage urbanism and other movements within the posthumanities broadly considered often treat cosmopolitics, initially proposed by Isabelle Stengers and subsequently taken up by Bruno Latour, as a single coherent concept. However, Stengers’s cosmopolitics differs considerably from Latour’s. The difference is most clearly visible in their contrasting positions on the concept of universality. Even though their divergence on universality could be considered a minor philosophical dispute among intellectual allies, it should not be underestimated. It determines what sort of political practice each of these philosophers envisions with cosmopolitics. Their visions of political practice are substantially different. This article will examine Latour’s and Stengers’s diverging positions on universality, delineate the two types of cosmopolitics, and, finally, analyze what sort of political practice each of these cosmopolitics implies.

The Janus Face of Polish Cultural Diplomacy in Paris during the Khrushchev Thaw

The Khrushchev Thaw allowed Poland a slightly larger margin of freedom in its cultural exchange with Western Europe than it had since the end of the Second World War. In this newly relaxed political climate, two models of Polish cultural diplomacy emerged in the West. The first constituted the official foreign policy of Poland’s communist authorities, while the other remained unofficial, relying on a network of contacts with Poland’s government-in-exile. An examination of contemporary Polish art exhibited in Paris during the 1950s and 1960s reveals this dichotomy. The first type of cultural patronage was coordinated in Paris by communist representatives of the Polish Embassy. The second emerged in Paris within Polish political émigré circles. Its key proponents were the Literary Institute (Instytut Literacki), including the intellectual and artistic milieu of the monthly journal Kultura (“Polish-based Culture”) and the Lambert Gallery (Galeria Lambert). State foreign policy, funded by the state budget and anchored in agreements between Poland and France on cultural cooperation determined the former, while the latter constituted an oppositional stance against the Eastern Bloc, deriving its strength from the resolve of Polish political émigré circles, their extensive network of sympathetic foreign contacts, and an understanding of the mechanics of the art market. The communist model sought to build a friendly image of Polish culture despite the apparent ideological rift between Eastern and Western Europe. The émigré approach stemmed from a refusal to accept the political division of Europe and involved searching the world of art for evidence of forces in Poland that opposed the political status quo. Finally, the patronage model adopted by communist authorities followed the state-imposed policy of favoring figurative art over Polish abstract art, whereas the model championed by émigré circles pursued the opposite strategy. It showcased unrestrained, spontaneous, and mostly abstract art. It evidenced an affinity for international trends in the art of the time, including abstract expressionism and, in particular, Parisian Art Informel. How can these two strands of cultural diplomacy co-exist? Which resonated more with international audiences?

The Janus face of supervision – quality control or learning? A study of supervision of employees in the Norwegian Child welfare service

ABSTRACT Supervision of employees in child welfare services (CWS) has many functions. Developments in recent years show that the function of supervision as an instrument for quality control has been strengthened. This can weaken the function of supervision as a source of learning and development. It appears that there is relatively little research on how managers and employees in the CWS perceive the balance between supervision as quality control, and supervision as a means of developing the CWS into a service that can continuously improve its practice, and become a learning organization. In our research we focus on in what way can supervision of employees in the CWS contribute to quality development and learning? We have interviewed both Child Welfare Managers and employees in Norwegian CWS. Both parts agree that case supervision is important for quality control, but this must be balanced against the need for a critical voice in supervision, and learning from each other in collective learning processes, where process supervision can play a very important role. In the Norwegian CWS, the employees in particular believe that process supervision must be better safeguarded than what they experience in current practice.

The emerging Janus face of SVEP1 in development and disease.

Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.

The Janus Face of Democracy and Populist Tendencies

The Janus Face of Democracy and Populist Tendencies

The Neglected Uterine NK Cells/Hamperl Cells/Endometrial Stromal Granular Cell, or K Cells: A Narrative Review from History through Histology and to Medical Education.

Reproductive immunology is at the forefront of research interests, aiming to better understand the mechanisms of immune regulation during gestation. The relationship between the immune system and the implanting embryo is profound because the embryo is semi-allogenic but not targeted by the maternal immune system, as expected in graft-versus-host reactions. The most prominent cell population at the maternal-fetal interface is the population of uterine natural killer (uNK) cells. Uterine NK cells are two-faced immunologically active cells, bearing comparison with Janus, the ancient Roman god of beginnings and endings. Their first face can be seen as natural killer cells, namely lymphocytes, which are critical for host defense against viruses and tumors. Even though uNK cells contain cytolytic molecules, their cytotoxic effect is not applied to classical target cells in vivo, playing a permissive rather than a defensive role. Their second face is crucial in maintaining physiological gestation-uNK cells show critical immunomodulatory functions with the potential to control embryo implantation and trophoblast invasion, regulate placental vascular remodeling, and promote embryonic/fetal growth. Therefore, we believe that their current designation "natural killer cells" (the first "cytotoxic" Janus's face) is misleading and inappropriate, considering their principal function is supporting and maintaining pregnancy. In this narrative review, we will focus on three lesser-known areas of knowledge about uNK cells. First, from the point of view of histology, we will comprehensively map the history of the discovery of these cells, as well as the current histological possibilities of their identification within the endometrium. To be brief, the discovery of uNK cells is generally attributed to Herwig Hamperl, one of the most influential and prominent representatives of German pathology in the 20th century, and his co-worker, Gisela Hellweg. Secondly, we will discuss the interesting aspect of terminology, since uNK cells are probably one of the human cells with the highest number of synonymous names, leading to significant discrepancies in their descriptions in scientific literature. From the first description of this cell type, they were referred to as endometrial granulocytes, granular endometrial stromal cells, or large granular lymphocytes until the end of the 1980s and the beginning of the 1990s of the last century, when the first publications appeared where the name "uterine NK cells" was used. The third area of present review is medical teaching of histology and clinical embryology. We can confirm that uNK cells are, in most textbooks, overlooked and almost forgotten cells despite their enormous importance. In the present narrative review, we summarize the lesser-known historical and terminological facts about uNK cells. We can state that within the textbooks of histology and embryology, this important cell population is still "overlooked and neglected" and is not given the same importance as in fields of clinical research and clinical practice.

The Janus face of proliferating plasmablasts in dengue and COVID-19 infections.

B cells play an integral role in the immune response to both dengue fever and COVID-19. Prior scRNAseq analyses of peripheral plasmablasts in COVID-19 have revealed a heterogeneous population with distinct cell subsets associated with proliferation; prior studies in patients with dengue fever have likewise shown the presence of proliferative pre-plasmablasts in the circulation. These findings may have implications for disease severity. In this study, we sought to gain a mechanistic understanding of the intracellular processes in naive and memory B cells that are associated with and may lead to an expanded proliferative plasmablast population in the circulation. We analyzed age-controlled (pediatric and adult), peripheral blood mononuclear cell scRNAseq datasets from patients infected with either dengue (primary or secondary) or COVID-19 (non-severe or severe) from previously published studies. Our preliminary analysis showed that pediatric patients with dengue and adults with COVID-19 had an expanded proliferative plasmablast (p-PB) population. By contrast, neither the adults with dengue nor the children with COVID-19 in our dataset had p-PBs. We used this distinctive preliminary signature to guide our analyses design and expanded our analyses to naive and memory B cells. In age/disease conditions with and without p-PBs, we found differences in cell sensing and activation, including via the B cell receptor and downstream signal transduction. Likewise, inflammation was mediated differently: relative to groups without p-PBs, those with p-PBs had increased expression of interferon response and S100 genes (particularly severe COVID-19). Furthermore, several transcription factors at the nexus of activation, inflammation, and cell fate decisions were expressed differently in groups with and without p-PBs. We used dengue and COVID-19 infections in adult and pediatric patients (focusing on naive B, memory B, and plasmablast cells) as a model to better understand the mechanisms that may give rise to p-PB populations in the circulation. Our results indicate that a more pro-inflammatory state in naive and memory B cells correlated with - and could influence the generation of- proliferating plasmablasts. Further exploration of these mechanisms will have implications for immune memory, vaccine development, and post-viral autoimmune syndromes.

Mono- and Difluorinated Saturated Heterocyclic Amines for Drug Discovery: Systematic Study of Their Physicochemical Properties.

A comprehensive study of physicochemical properties (pKa , LogP, and intrinsic microsomal clearance) within the series of mono- and difluorinated azetidine, pyrrolidine, and piperidine derivatives was performed. While the number of fluorine atoms and their distance to the protonation center were the major factors defining the compound's basicity, both pKa and LogP values were affected considerably by the conformational preferences of the corresponding derivatives. For example, features of "Janus face" (facially polarized) cyclic compounds (i. e., unusually high hydrophilicity) were identified for cis-3,5-difluoropiperidine, preferring a diaxial conformation. Intrinsic microsomal clearance measurements demonstrated high metabolic stability of the compounds studied (with a single exception of the 3,3-difluoroazetidine derivative). According to pKa - LogP plots, the title compounds provide a valuable extension of the fluorine-containing (e. g., fluoroalkyl-substituted) saturated heterocyclic amine series as building blocks for rational optimization studies in early drug discovery.

The Janus Face of Valuation: Global Performance Indicators as Powerful and Criticized Public Measures

The article conceptualizes global performance indicators as public measures that are powerful but also receive a wide range of criticism. Global performance indicators derive their power from combining three analytically distinct elements: (a) commensuration (comparing performances on a common metric), (b) visual simplification (presenting performances in an appealing format), and (c) serialization (framing performance as a continuous developing property). However, the very same elements are often subject to criticism. The producers of global performance indicators, therefore, defend methodologies and the validity of commensurated numbers, meet charges of visual oversimplification by professing sobriety and nuance, and balance temporal continuity and discontinuity. By conceptualizing global performance indicators as powerful and criticized public measures, the article draws attention to the Janus face of valuation, which the producers must tackle continuously. Investing considerable time, energy, and resources, these organizations are a key feature of today’s vast indicator culture.

GENERASI KEDUA DIGITAL NATIVE: JANUS FACE MEDIA SOSIAL DAN ANOMALI KOMUNIKASI

Today's students are understood as second generation digital natives (GDN-2) who are close and accustomed to using social media. Previous research explains digital natives in general, the role of social media in digital natives' daily lives. This study focuses on looking at the janus face of social media in GDN-2, the role of the family and their participation in social media. 308 students were willing to fill out a questionnaire as initial data, then in-depth interviews were conducted (N= 31). The research results show that the benefits of social media for GDN-2 are to share information and opinions, reach consumers and add business ideas, a place to learn and reference material, update information, and build relationships. Social media is detrimental to work and main activities, addiction, wasted time, lazing, having to pay for the internet, and false information. There is a family communication anomaly, parents do not have social media but give advice to their GDN-2 children to use social media wisely. This is then reflected in GDN-2's participation on social media. They are careful about spreading information that is not necessarily true, posting and commenting carefully.

The Janus Face of Organizational Knowing

This article challenges our current understanding of the role of knowing for organizational participation by discussing how, and under which circumstances, knowing hinders participation instead of fostering it. Drawing upon 18 months of fieldwork at a social impact accelerator, I first show that showing that the knowing emerging from collective practices and interactions generates disengagement among actors. Second, I illuminate the role of the social relations for actors to imbue their experience of new meanings and, third, develop a model of “meaningful reengagement” explaining how they retain their participation beyond the negative implication of knowing for participation. This article advances existing knowing research by bringing to the fore the role of relational patterns for participation, strengthening its relational but underdeveloped ambition, and providing insights for research on business accelerators and practitioners alike.

Unclearing the Air: The Pneumatological Dalliances of Jacques Derrida

Abstract In the 1980s, Luce Irigaray accused Western philosophy of “forgetting” about the role that the materiality of air and the act of breathing played in pre-Socratic metaphysics. This essay explores how Jacques Derrida maintained a complicated but insightful relationship to the air throughout his career through the mediating influence of pneuma, a word with long and complicated connections to the air. I highlight two relevant sites of engagement. The first was found in Of Grammatology (1968), where he connected the breathy logocentrism of “natural writing” to a concept of pneumatology (a “science of spirit” with some interesting connections to Leibniz) that served as grammatology’s Janus face. The second stemmed from Of Spirit (1991), in which Derrida emphasized the combustible, fiery face of pneuma to lambast Heidegger’s use of translation to mediate away the historical presence of the word pneuma for ideological purposes. This body of work, en toto, presents a subtle and oblique critique of Irigaray’s position. For Derrida, the air cannot function as the medium for an alternative metaphysics of presence because, historically, its space has already been infused with a pneumatic specter that cannot be ignored.

The Emergence and Properties of Selectively Fluorinated 'Janus' Cyclohexanes.

This account describes the evolution of a research programme that started by linking fluoromethylene (-CHF-) groups along aliphatic chains and then progressing to alicyclic rings with contiguous fluorine atoms. Different stereoisomers of aliphatic chains tend to adopt low polarity conformations. In order to force polar conformations, the programme began to address ring systems and in particular cyclohexanes, to restrain conformational freedom and co-aligned C-F bonds. The flagship molecule, all-cis-1,2,3,4,5,6-hexafluorocyclohexane 7, emerged to be the most polar aliphatic compound recorded. The polarity arises because there are three co-aligned triaxial C-F bonds and the six fluorines occupy one face of the ring. Conversely the electropositive hydrogens occupy the other face. These have been termed Janus face cyclohexanes after the Roman god with two faces. The review outlines progress by our group and others in preparing derivatives of the parent cyclohexane 7, in order to explore properties and potential applications of these Janus cyclohexanes.

TrkA Co-Receptors: The Janus Face of TrkA?

Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has been observed in the absence of other mutations in cancers with an NTRK fusion. Furthermore, when TrkA is overexpressed, it promotes ligand-independent activation, bypassing the TKI. All of these clinical and experimental observations show that genetics does not explain all therapeutic failures. It is therefore necessary to explore new hypotheses to explain these failures. This review summarizes the current status of therapeutic strategies with TrkA inhibitors, focusing on the mechanisms potentially involved in these failures and more specifically on the role of TrkA.