Schizophrenia (SZ) is a complex mental disorder marked by structural abnormalities in brain regions such as gray matter (GM), white matter (WM), ventricles and the cerebellum. Accurate segmentation of these brain subregions is crucial for diagnosing SZ, but traditional methods often struggle with the complexity of the disorder. To address this, the study employs advanced optimization techniques, specifically Cuckoo Search (CS), Grey Wolf Optimization (GWO) and Improved Grey Wolf Optimization (IGWO), to segment regions extracted from T1-weighted MR images of SZ patients and HC/NC. The IGWO method consistently outperforms others, achieving Structural Similarity Index Measures (SSIM) of 0.98 for ventricles and 0.96 for the cerebellum, with segmentation accuracies of 99% for both regions. Overlapping measures also reflect the effectiveness of proposed method, with DICE coefficients of 0.89 (SZ) and 0.94 (healthy controls) for ventricles and JACCARD indices of 0.80 and 0.95, respectively. For the cerebellum, DICE coefficients were 0.89 (SZ) and 0.93 (healthy controls), with JACCARD indices of 0.79 and 0.88. Subsequent classification using the ResNet50 deep learning model achieved high accuracy rates, particularly for the cerebellum (94%) and ventricles (93%). Performance metrics including recall, specificity, precision and F1-score further validate the robustness of the proposed method. These results highlight the significant role of the cerebellum and ventricles in SZ progression and offer an enhanced approach to improving diagnostic accuracy.
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