This paper investigates the collapse of ring-stiffened Titanium alloy cylinders used for subsea resource exploration under hydrostatic pressure through experimental and numerical methods. Extensive material tests were first conducted on Titanium alloy specimens to obtain the fundamental mechanical properties and variation characteristics. Then, a 4236 mm-long test cylinder was fabricated with an inner radius of 650 mm and a thickness (ts) of 18.85 mm. The initial geometric imperfection was measured at evenly-spaced positions in the axial direction and 48 locations around the circumference by dial gauges. Afterward, the test cylinder was transferred into a custom hyperbaric pressure vessel and pressurized to collapse. As to the numerical analysis, a user-defined material subroutine implementing the incremental J2 deformation theory was developed to predict plastic bifurcation pressure. Moreover, a nonlinear finite element (FE) model, which incorporated the measured geometric imperfection and material nonlinearity, was used to reproduce the experiment. The numerical results were found to exhibit reasonably good agreement with the test data. In addition, parametric studies were conducted regarding material properties, geometric parameters, and imperfection sizes on the load-carrying capacity of Titanium alloy ring-stiffened cylinders.