Aim Introducing NGS technology to the laboratory creates a need for additional IT infrastructure in comparison to previously introduced technologies. After a comprehensive evaluation, the Immucor Mia Fora NGS Flex kits were selected to be introduced into the Melbourne and Sydney laboratories running on the Illumina NGS platforms. Methods We immediately engaged with our IT department to detail a plan for roll out. The initial focus of the roll out required a decision on the software platform and server; Immucor offered both a Linux and a windows software application and provision of the application server. As NGS generates a significant volume of data, the plan required evaluation of the ability of the network to support transfer of large data files across the LAN and WAN and provision for centralised storage of the data. The requirements for system support, data backup/retrieval and provision of a test environment also needed to be determined. At the Blood Service all laboratory supported software applications are classified as requiring a particular IT service level based on the nature of the clinical service. We assessed the NGS solution as ‘Gold’ service level, requiring that our IT department could return the application to service within 24 h, with zero data loss; hence a robust backup design including disaster recovery was required. Results The Windows application and software were selected and the IT department determined that the best solution was to provide a local server compatible with existing application servers to be centrally located in Melbourne. The detailed rollout plan included a solution architect design to meet the above requirements including the installation and operational qualifications. Conclusions Early engagement with our IT department ensured a comprehensive data management solution for roll out of the NGS technology.