In GH deficiency, rhGH is deemed appropriate when epiphyses are open, while Turner's syndrome poses unique considerations due to associated malformations like cardiac aortic bicuspidity and aortic coarctation. Renal malformations, including Horseshoe kidney and hydronephrosis, further highlight the complexity of Turner's syndrome, requiring a comprehensive, multidisciplinary approach to care. We report the case about of an elderly child 3 years and 5 months old patient with cardiac and renal malformations notably a tight postductal isthmic coarctation and a left pyeloureteral junction syndrome with dilatation of the pyelocalic cavities, admitted for further management of a staturo-ponderal delay. She presented with functional signs of constipation, no chills, no digestive disorders and no hypoglycemic malaise. On physical examination, dysmorphic features included low hairline and short neck, pterygium coli, low ear implant, hypertelorism, nipple spread, keloid lesion on face. Test results showed a 45x karyotype in favour of Turner syndrome, HBA1c: 5.6%, the rest of the tests were normal. GH was indicated in the patient after cardiac surgery for coarctation of the aorta and pyelo-caliceal junction. The patient was referred for heart and kidney surgery. It is crucial to closely monitor height velocity during catch-up growth, particularly in patients with concurrent conditions leading to short stature. Additionally, there is an emphasis on educating parents about the potential impact of Turner syndrome on aspects such as growth, growth hormone (GH) substitution, ovarian failure, malformations, and related health risks.