More than once over the past several years, I have been asked to make a presentation on my program of research. Of course, this is always my favorite speaking assignment. More recently, however, I was tasked with assisting a group of more fledgling nurse scholars to develop their programs of research. While also a very enjoyable and certainly a longer ranging assignment, I am finding that the effort also is considerably more intellectually challenging. To illustrate the meaning and process of developing a program of research for these more novice researchers, I could easily rely on my own work as a point of reference, but that is certainly not enough to provide a model or paradigm that can serve the diversity of interests within the group. Therefore, I set out to locate some explicit and structured guidance to share with them for thinking about research programmatically. The literature was replete with dozens-even hundreds-of examples of research programs on a wide array of topics and at all scales of magnitude. However, I found little explicit guidance on how to proceed in conceptualizing a specific program of research. Nevertheless charged with moving this group of individuals forward to do just that, what I can offer them and here are my thoughts on the matter. These thoughts are based largely on my experience in attempting to develop my own meaningful program of nursing research and my exposure over the years to various established nursing research programs; they are also supported by current published and national paradigms inspired by the "bench to bedside" (and beyond) movement emanating in recent years from the National Institutes of Health (NIH). BEGINNING AT THE BEGINNING: WHAT IS A PROGRAM OF RESEARCH? It seems that the notion of a research program derives from efforts by Lakatos to resolve an issue in philosophy of science between Popper's strict falsificationism and Kuhn's revolutionary structure of science. In brief, Lakatos (Lakatos, 1978; Lakatos & Musgrave, 1970) sought to explain the process by which scientists evolved and evaluated theories such that the basis for concluding superiority (rather than truth or falsity) of one over another was both rational (i.e., it resolved Popper's problem of counterevidence) and consistent with the behavior of scientists (i.e., the doing of Kuhnian normal science during which counter evidence is seemingly unaddressed until the sudden emergence of new theories that better encompass or account for them). Lakatos used the term research programme to refer to a succession of studies to advance a central idea or theory (termed the hard core) over time, during which slightly varying versions of it (in the form of auxiliary hypotheses) were evaluated by devising and applying new and evolving research methods. When such programs of study succeeded in building support for the central theory by revealing new and remarkable facts, generating new experimental approaches, and resulting in more precise predictions, they were considered progressive; those programs unable to build support or generate new facts were considered as degenerating. Lakatos's notions were illuminating, but perhaps somewhat removed from the current experience and practical purpose at hand for these researchers. What was needed was a definition for what I was calling a program of research that could guide these young researchers to conceptualize a direction for their work. In a limited but effortful search of the literature and World Wide Web, I found only one on Wikipedia that defined a research program as "a coordinated set of projects undertaking related research, often at national or even international level, with government funding" ("Research Program," 2009, para. 1). Believing that definition to lack clarity and to impose unnecessary restrictions for my purpose, I devised my own definition, thusly, as an advancing series or cluster of studies under the leadership of a scientist or a group of scientists that systematically builds knowledge in a focal area. …