This mixed-methods study examines two research areas concerning whether U.S. women college students, compared with men, enrolled in online classes during the pandemic suffered from stress regarding their ability to socialize and negotiate a community/national political issue(s) affecting them negatively academically in terms of their grade point average and course outcomes, as well as whether the women would experience a sense of belonging and camaraderie with classmates by discussing topics impacting their identities and circumstances in terms of their individual and communal, social-relational, health, and financial pandemic contexts, which might also influence them negatively academically as stressors linked to their course outcomes and progress. Conducted in a rural, geographically marginalized area, the study implements survey and short-answer question instruments and utilizes an exploratory case-study design and a convergent-parallel strategy assessing 188 women and 188 men participants, including racial/ethnic minority and low socio-economic status (SES) women, with women’s median age of 23. of women and men surveyed, the former reported statistically significantly higher stress levels than men connected to the women’s need to socialize and tackle pandemic-oriented community and national political issues affecting their lives and statuses, which subsequently influenced their academic progress. Overall, the pandemic damaged women, especially racial/ethnic minorities, more than men, with women having higher stress rates revolving around their need for socializing (59% versus 33%) and addressing political issues (54% versus 32%), stressors hampering the women’s academic outcomes and status, as well as some experiencing additional stress regarding health and financial concerns. In response to these settings, 21% of women (n = 40) desired to discuss controversial topics, such as their pandemic stressors and related experiences in the classroom, including the pandemic’s political consequences for themselves, to promote self-expression, forge bonds, and seek and provide assistance in addressing all classmates’ academic, personal, and community needs.