Undoubtedly, no countries have been, by now, the host and under the influence of pressure groups as far America would, the issue make difficult to make a decision in foreign policy affairs, because of the benefits and the valuation system in America. It seems that among the pressure groups in America, the Israel lobby in America has the most influence on the foreign policy-making; accordingly it can be said almost there has been a special relationship between America and Israel after World War II and AIPAC always guarantees this relationship to continue. In shaping the foreign policy of any country, a collection of internally, nationally and internationally different-level factors would contribute that the outcome of the interaction between these factors has been provided as an output and called by "foreign policy". United States of America's foreign policy has been the outcome of such a process, accordingly, on the basis of theories of international relations that the internal level would be the most essential level of the analysis of the foreign policy of the United States of America, which one of its components is to examine the role of pressure groups in shaping this country’s foreign policy, actually in this regard, there is no the most prominent and significant lobby group except Israel lobby in America. So, author intends to investigate the influence of various forms of Israel lobby and this regime position and performance within America’s foreign policy against Iran and thereby, the lobby’s directed activates in the arena of Iran were investigated; followed by the research process, stated that the penetrating element in the decision-making system of the United states of America is undeniably in terms of the Israeli-centered influential lobby groups’ contribution and the unsparing support of the United states for this lobby.