Objective: To assess the frequency of Hepatocellular carcinoma in cirrhotic patients with hepatitis-C virus positive patients. Methodology: This study descriptive Cross-Sectional Study was conducted at Gastroenterology department, Isra University Hospital, Hyderabad, Pakistan, during Six months after the approval of synopsis from February 22, 2020 to August 21, 2020. Patients aged 25 to 60 years old, diagnosed as the cases of cirrhosis for more than five years, caused by hepatitis C of either gender, were included. Patients were evaluated clinically, biochemically, and serologically at baseline. CT scan of liver was done to assess hepatocellular carcinoma. A specially designed Proforma was utilized to gather the information, which was then input and analyzed employing SPSS version 23. Results: The participant's mean age is 42.3 years, with a standard deviation of 7.5 years, and an average body mass index (BMI) reached 16.9+3.6kg/m2. Additionally, the mean duration of cirrhosis is reported as 12.5 years. Majority of the patients were males 74.6%. Among all study participants with liver cirrhosis for over 5 years, 8.30% of patients had developed hepatocellular carcinoma. The HCC occurrence rate was statistically significant, with 1.9% of individuals aged 25-40 years and 6.4% of those over 40 years having hepatocellular carcinoma (p=0.008). However, gender, BMI categories, diabetes mellitus and hypertension did not show a significant association (p->0.05). Conclusion: In conclusion, hepatocellular carcinoma appeared relatively prevalent among patients having cirrhosis with hepatitis-C virus. Advanced age emerged as a significantly predominant factor contributing to hepatocellular carcinoma.
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