AbstractPyrazole, β-lactam, salicidine, pyren and oxazole derivatives exhibit a broad spectrum of biological activities such asantimicrobial, anti-inflammatory and antitumor activities. With growing application on their synthesis and bioactivity,chemists and biologists in recent years have considerable attention on the research of these derivatives. In the view ofpotential importance of these derivatives, we have crystallized few of the derivatives and its report has been published.The present study focuses on docking studies of these derivatives against COX-2 enzyme. Docking studies usingSchrodinger’s GLIDE reveals that these derivatives shows better binding energy and score in the defined active site. Theseresults may provide a guiding role to design a lead molecule which may reduce inflamation. Key words: Pyrazole, Oxazole, β-Lactam, Anti-inflammation, COX-2, Molecular Docking 1. Introduction Cyclooxygenase (COX-2) is one of the isoforms ofProstaglandin synthase H2 (PGH2) which synthesisprostaglandin necessary for organ and tissue homeosta-sis. COX-2 is expressed only in certain mammalian tis-sues in response to inflammatory stimuli. Hence COX-2 is responsible for the elevated prostaglandin levelswhich cause inflammation