Ischemic Stroke In Young Population Research Articles

Etiology and risk factors of stroke in young adults: A multicentric study.

ObjectiveThe main objective of this research was to assess the risk factors and causes of ischemic stroke in the young population (age less than 50 years).MethodsThis was a prospective multicenter study conducted at Pakistan Atomic Energy Commission General Hospital, Islamabad, and Mayo hospital Lahore from June 2019 to June 2020. In this research, patients with ischemic stroke, aged 15–50 years were included. Prior to noting demographics, each patient gave ethical approval via filling out consent forms. After that, all demographical details including residence, education, gender and age, and socioeconomic status were noted. Risk factors were evaluated on the questionnaire proforma. Outcomes were measured using the modified Rankin scale (MRS) score. Additionally, data were analyzed by using SPSS V26. A P-value of <0.05 was set as statistically significant.ResultsOut of 80 patients, 53 (66.25%) were male, while 27 (33.75%) were female. Six (7.5%) patients were between the ages of 15 and 25 years, 18 (22.5%) patients were between 26 and 35 years, 48 (60%) patients were between the ages of 36 and 45, and eight (10%) patients were between the ages of 46 and 50. According to this research, hypertension was found to be the most frequently occurring risk factor in 28 participants (35%), Diabetes mellitus in 23 patients (28.75%), dyslipidemia in 20 patients (22.5%), and smoking in 18 patients (22.5%). The etiology remained undetermined in 30 patients (37.5%). Most of the patients (87.5%) reported positive functional outcomes (MRS score 0–2). However, 3 (3.75%) patients died during the study period.ConclusionThis research showed that common risk factors of ischemic stroke in the local young population included hypertension, diabetes mellitus, and smoking, whereas the etiology of stroke remained unidentified in the majority of patients.

Association between PDE4D polymorphism and ischemic stroke in young population.

ObjectiveTo explore the association between the polymorphisms of the phosphodiesterase (PDE) 4D gene (SNP83 and SNP87) and the risk of ischemic stroke (IS) in Chinese young population.MethodsThis study included 393 patients who were divided into IS group and non-IS group. Semiconductor high-throughput sequencing technology and multivariate logistic regression analysis were performed.ResultsIn the case group, the frequency of CC genotype and C allele of the SNP83 gene was significantly higher than that in the control group. There was no significant difference in genotype frequency distribution of SNP87 between the two groups.ConclusionWe found an association between SNP83 and the risk of IS in Chinese young population from northern Henan province. There was not a significant association between SNP87 and IS in Chinese young population.

Migraine as a risk factor for young patients with ischemic stroke: a case-control study.

Studies have suggested a possible association of migraine and increased risk of ischemic stroke in young adults, particularly in smokers and in women who use oral contraceptive drugs. We aimed to analyze the association between migraine and ischemic stroke in young population in a hospital-based cohort. We included 202 consecutive patients with the diagnosis of ischemic stroke who were between 15 and 50years and age- and gender-matched 250 volunteers with no history of stroke. All participants were interviewed using a questionnaire for migraine. Localization of ischemic lesion was classified as anterior and posterior circulation according to neuroimaging findings. The cause of ischemic lesion and all risk factors were recorded. Undetermined etiology was the most frequent (43.1%) and the most common determined cause was cardioembolism (22.3%) in young stroke patients. Frequency of migraine was 30.2% among patients with stroke whereas 16.8% of healthy subjects had migraine (p=0.001). Migraine with aura was significantly more common among patients with stroke compared to healthy subjects (18.3 vs 4.4%; p=0.000) whereas the frequency of migraine without aura was similar in both groups (11.9 vs 12.4%). Using logistic regression, migraine with aura was shown to be an independent risk factor for ischemic stroke in young population (p=0.000) and separate analysis for gender demonstrated that it was only a risk factor for women (p=0.009) but not for men (p=0.107). Migraine with aura was found to be more common in ischemic stroke in young patients. It was an independent risk factor in women.

Protein S Deficiency: Ischemic Stroke in Young adult – A Case Report

Stroke is the third most common cause of mortality in Westernised countries and Accounts for 12% of all deaths in the UK. The economic cost of stroke is enormous. Twelve per cent of first strokes occur in patients under 45 years of age, of which approximately 50% are ischaemic in nature. Stroke in young adult poses a major health problem. The causes of ischaemic stroke in young adults are many and diverse.Such patients usually require more extensive investigations in order to find an underlying cause than more elderly patients. Principal causes are cardioembolism, premature atherosclerosis, haematological and immunological disorders and migraine. Thrombophilic factors have been implicated in 4-8% of the young adult strokes worldwide. Protein S deficiency is a rare cause of ischemic stroke in young population. Only a few sporadic cases have been described in the literature. We are reporting a case of protein S deficiencyrelated ischemic stroke in a 40-year-old man. Early diagnosis and targeted approach can help such patients to prevent recurrent thrombotic episodes.Bangladesh Journal of Neuroscience 2012; Vol. 28 (1): 59-62

Protein S deficiency: Recurrent ischemic stroke in young

Stroke in young poses a major health problem. Thrombophilic factors have been implicated in 4-8% of the young strokes worldwide. Protein S deficiency is a rare cause of recurrent ischemic stroke in young population. Only a few sporadic cases have been described in the literature. We are reporting a case of protein S deficiency-related recurrent ischemic stroke in a 16-year-old girl. Early diagnosis and targeted approach can help such patients to prevent recurrent thrombotic episodes.

Biventricular non-compaction — The rare cause of stroke in a young boy

The ischemic stroke in young population is mostly because of non-atherosclerotic etiologies like cardiogenic embolism, arterial dissection, procoagulant states and inflammatory arteritis. We report a young 18 years old boy, who had right hemiparesis secondary to cardiogenic embolism. Echocardiography was consistent with biventricular non-compaction. In non-compaction of the myocardium, the embolic complications are related with development of thrombi in the extensively trabeculated ventricle, depressed systolic function, and onset of atrial fibrillation. It is rare to have biventricular non-compaction as a cause of cardioembolic stroke in young individual.