Ischemic Regurgitation Research Articles

Histórico de reparación mitral en un centro de referencia autonómico español

IntroductionValve repair in mitral valve regurgitation needs dedicated training and expertise enough to achieve excellent results. The global mitral valve repair national rate is about 30%.The aim of the study is to show the outcomes in mitral repair in a national reference center. MethodRetrospective study to assess all patients undergoing isolated or combined mitral repair from December 2002 to December 2021 from cardiovascular surgery department in our center. Descriptive analysis of preoperative and intraoperative characteristics and postoperative outcomes was performed. Results934 patients were included, with average age of 68 years and median EuroSCORE Log and II of 8.15% and 5.22% respectively. Overall mitral repair rate was 63.5%. Preoperatively, 35.7% of patients presented congestive heart failure with 35% patients with left ventricular dysfunction ≤40%. Main etiology of mitral regurgitation was degenerative (42.5%) followed by ischaemic regurgitation (25.3%). Almost 65% of patients underwent a complex mitral valve repair.Overall operative mortality was 2.1%, with main prevalence in endocarditis and ischaemic etiologies. Major adverse complications rate was 6.3% with median hospital stay of 9 days. 98% of patients had residual mitral regurgitation grade<2 (72% with 0 grade). Mitral reintervention rate was 2.4% after average follow-up of 104 months. ConclusionsThis study displays excellent results in mitral repair rate, mortality, residual regurgitation and need for mitral reintervention in our center, comparable to best international series.

Clinical presentation and prognosis of non valvular mitral regurgitation-A single institution experience

BackgroundNon valvular, ischemic regurgitation (MR) occurs secondary to myocardial infarction or acute ischemia. The presence of ischaemic MR is associated with increased morbidity and mortality. The severity of ischaemic MR is directly proportional to the severity of the LV dysfunction causing the MR. The present study was carried out to estimate the burden, clinical presentation and prognosis of non valvular MR among patients with coronary artery disease. MethodsThis cohort study was carried out among 75 adults aged over 25 years with electrocardiographic evidence of coronary artery disease. Clinical examination and periodic electrocardiography was done for evaluating the ischemic status and echocardiogram was done to assess the status of mitral regurgitation. Ejection fraction was measured by Simpsons method and regional wall motion abnormality was qualitatively evaluated. ResultsIn this study, 60% of the participants had mild MR while 22.9% had moderate MR. In correlation with STEMI, inferior/posterior wall MI with right ventricular extension showed presence of MR in 100% of the cases. There was a statistically significant difference in the incidence of congestive cardiac failure among the patients with severe MR (66.7%) and mild MR (25%) compared to those without CCF (p < 0.01). ConclusionIschemic MR is characteristically dynamic and can change substantially with changes in loading conditions. This study has laid down the basis for evaluating future role of new adjunctive surgical techniques and of percutaneous interventions.

10-Year Results of Mitral Repair and Coronary Bypass for Ischemic Regurgitation: A Randomized Trial

BackgroundThe decision to treat moderate ischemic mitral regurgitation (IMR) at the time of coronary artery bypass surgery (CABG) remains controversial. We previously conducted a prospective randomized trial that showed a benefit of adding restricted annuloplasty to bypass surgery (CABG-Ring group) in terms of IMR grade, New York Heart Association classification, and left ventricle reverse remodeling. Here, we present the long-term (>10 years) follow-up data from this randomized trial. MethodsThe original trial arms accounted for 54 patients in the CABG-alone and 48 in the CABG-Ring group; patients were re-contacted for follow-up to obtain relevant clinical and echocardiographic information. ResultsThe mean follow-up was 160.4 ± 45.5 months. Survival probabilities in the CABG-alone and CABG-Ring groups were 96% vs 93% at 3 years, 85% vs 89% at 6 years, 79% vs 85% at 9 years, 77% vs 83% at 12 years, and 72% vs 80% at 15 years, respectively (P = .18) Freedom from at least moderate IMR or reintervention at last follow-up was also higher in the CABG-Ring group (P < .001). Compared with the CABG-alone group, the CABG-Ring group had a higher degree of left ventricular reverse remodeling (54.7 ± 6.9 mm vs 51.6 ± 6 mm, respectively; P = .03), lower New York Heart Association class (P < .001), and a lower rate of rehospitalization (P = .002). ConclusionsLong-term follow-up data from our randomized trial further support the utility of performing restricted annuloplasty at the time of CABG to prevent further progression of IMR, mitral reintervention, and left ventricle remodeling. Untreated IMR was associated with significantly higher New York Heart Association class and rehospitalization.

Mimicking natural mitral adaptation to ischaemic regurgitation: a proposed change in the surgical paradigm.

Mimicking natural mitral adaptation to ischaemic regurgitation: a proposed change in the surgical paradigm.

Feasibility of Self-Powering and Energy Harvesting Using Cardiac Valvular Perturbations.

In this paper, we investigate the feasibility of harvesting energy from cardiac valvular perturbations to self-power a wireless sonomicrometry sensor. Compared to the previous studies involving piezoelectric patches or encasings attached to the cardiac or aortic surface, the proposed study explores the use of piezoelectric sutures that can be implanted in proximity to the valvular regions, where non-linear valvular perturbations could be exploited for self-powering. Using an ovine animal model, the magnitude of valvular perturbations are first measured using an array of sonomicrometry crystals implanted around the tricuspid valve. These measurements were then used to estimate the levels of electrical energy that could be harvested using a simplified piezoelectric suture model. These results were revalidated across seven different animals, before and after valvular regurgitation was induced. Our study shows that power harvested from different annular planes of the tricuspid valve (before and after regurgitation) could range from nano-watts to milli-watts, with the maximum power harvested from the leaflet plane. We believe that these results could be useful for determining optimal surgical placement of wireless and self-powered sonomicrometry sensor, which in turn could be used for investigating the pathophysiology of ischemic regurgitation.

Assessment of Mitral Annulus (P3 Segment) Asymmetric Deformity in Myocardial Infarction with Ischemic Regurgitation by Real Time Three‐Dimensional Echocardiography

The three-dimensional (3D) saddle shape of the mitral annulus (MA) is well characterized in humans, but segmental MA deformity and regurgitation suffered after the ischemic damage of myocardial infarction (MI) is poorly understood. In this study, such changes were assessed in patients with ischemic mitral regurgitation (IMR) post-MI, using our computerized 3D echo technique. A patient cohort (n = 72) with IMR due to inferior or anterior MI and normal controls (n = 20) were enrolled for 3D MA echo studies. Sequential coordinates of MA were manually measured from each of 18 radial planes, cropped in midsystole, to generate 3D MA images. In addition, six segmental (A1, A2, A3, P1, P2, P3) parameters of MA and global features, such as circumference, area, and height, were calculated. All six segments of MA were significantly dilated in the IMR group compared with corresponding segments of normal controls. Although there were no significant intragroup differences in A1, A2, and A3 segments, a greater degree of P3 segmental MA deformity was observed only in patients following inferior MI. The MA dilatation observed in patients with IMR after MI was more pronounced in patients with anterior versus inferior MI. However, P3 segmental dilatation of MA was significantly greater in patients after inferior IM with significant IMR, corresponding with more severe asymmetric MA deformity. (Echocardiography 2012;29:42-50).

Details in a meta-analysis comparing mitral valve repair to replacement for ischemic regurgitation

Although meta-analyses are considered to be of great value to establish an overall effect on an investigated outcome, there are some basic ‘rules’ to such an analysis. Several statements have guided authors in reporting results from systematic reviews and have been increasingly cited to inform readers of the quality of the review [1]. In the March 2011 issue, however, a meta-analysis of short-term and long-term survival after mitral valve repair or replacement for ischemic regurgitation was published in which several details are missing [2].

RT-3D TEE: Characteristics of Mitral Annulus Using Mitral Valve Quantification (MVQ) Program

To evaluate the mitral annulus characteristics in significant mitral regurgitant lesions using mitral valve quantification (MVQ) program. We examined 117 patients (39 women), aged 18-86. Patients were separated into four subgroups: 35 patients with ischemic mitral regurgitation, 42 patients with isolated prolapse of the mitral valve, 12 patients with Barlow disease, and 28 healthy controls. Mitral annulus was examined in end-systole. The following parameters were assessed: anteroposterior and intercommissural diameter, perimeter of annulus, area of minimal surface spanning annulus and height of the mitral annulus. A new parameter--mitral annulus height index (height/circumference × 100) was introduced. Values of these parameters in subgroups with mitral pathology were compared with corresponding parameters of control group using Student t-test. In subgroups with mitral pathology all parameters except mitral annulus height and mitral annulus height index were significantly higher than those in the control group. Mitral annulus height was significantly higher in Barlow disease, significantly lower in mitral prolapse group and comparable to normal controls in the ischemic regurgitation group. Mitral annulus height index was significantly higher in Barlow disease and significantly lower in patients with prolapse and ischemic regurgitation. Barlow disease is characterized by dilation and vertical deformation of the mitral annulus (annulus height and height index increase). Prolapse of the mitral valve and ischemic regurgitation of mitral annulus involve dilation and flattening of the annulus (annulus height decreases in prolapse group significantly, in ischemic regurgitation nonsignificantly, while annulus height index decreases significantly in both subgroups).

Autologous Ring vs. Flexible Prosthetic Ring for Ischemic Mitral Regurgitation

Ring annuloplasty is the most common strategy for correction of ischemic mitral regurgitation. When a commercial prosthesis is unavailable or too expensive, an autogenous annuloplasty ring can be handmade by the surgeon. The aim of this study was to compare short-term results of mitral valve repair with autologous annuloplasty rings and the SJM Tailor flexible prosthesis. Between March 2004 and April 2006, 100 patients undergoing coronary artery bypass grafting and mitral ring annuloplasty for ischemic regurgitation were randomly assigned to either type of prosthesis. Transesophageal and transthoracic echocardiography showed no significant differences between these techniques in terms of immediate success of the repair and its durability at 3, 6, and 9 months postoperatively. Autogenous rings are easy to make, cost-effective, and always available. Our short-term results suggest that they may be an acceptable alternative to a commercially produced prosthesis for patients with ischemic mitral regurgitation.

Initial Results of Posterior Leaflet Extension for Severe Type IIIb Ischemic Mitral Regurgitation

Management of severe ischemic mitral regurgitation remains difficult with disappointing early and intermediate-term surgical results of valve repair. Forty-four patients with severe (4+) Carpentier type IIIb ischemic mitral regurgitation underwent mitral valve repair, with or without surgical revascularization, by posterior leaflet extension with a patch of bovine pericardium and a remodeling annuloplasty. Serial echocardiography was performed preoperatively, intraoperatively, and postoperatively to assess mitral valve competence. The postoperative functional status of patients was assessed. The average Parsonnet score was 38+/-13. Thirty-day mortality was 11%, and late mortality was 14%. Mean follow-up was 38 months. The actuarial freedom from moderate or severe recurrent mitral regurgitation was 90% at 2 years, whereas 90% of patients were in New York Heart Association class I at 2 years. Posterior leaflet extension with annuloplasty of the mitral valve for severe type IIIb ischemic regurgitation is a safe, effective method that provides good early and intermediate-term competence of the mitral valve and therefore good functional status.

A Novel Method of Percutaneous Mitral Valve Repair for Ischemic Mitral Regurgitation

This investigation sought to determine the feasibility of a novel method of a percutaneous mitral valve repair. Percutaneous mitral valve repair has emerged as an alternative therapy for patients with functional mitral regurgitation. However, current methods that rely on cannulation of the coronary sinus may not result in direct reduction of the mitral annulus area due to the superior relationship of the sinus to the annulus. A novel device, consisting of helical stainless steel screws connected by a biocompatible tether, was designed for percutaneous mitral valve repair. This device was implanted by implanting the helical screws directly into the myocardium at the posteromedial mitral annulus of 8 anesthetized pigs from the right internal jugular vein. Implantation of the device resulted in a 19.7 +/- 0.1% reduction in mitral annular area and an 18.8 +/- 0.1% decrease in the mitral anterior-posterior dimension (both p < 0.05 vs. baseline). This annular reduction persisted at 3-month follow-up. Both the coronary sinus and left circumflex coronary artery remained patent in all animals. There was no evidence of device migration, poor wound healing, or tissue thrombosis at the sites of device implantation. Percutaneous mitral valve repair targeting the ventricular myocardium from central venous access is feasible. By directly acting on the posteromedial mitral annulus, this methodology targets the mitral annular area most frequently affected by ischemic mitral regurgitation, lessens the risk of coronary artery impingement, promotes coronary sinus patency, and overcomes technical concerns that may arise when the coronary sinus lies significantly superior to the mitral annulus.

Surgical treatment of congenital mitral valve disease: Midterm results of a repair-oriented policy

Management of congenital mitral valve disease is challenging because of a wide morphologic spectrum, frequent associated lesions, and small patient size. We evaluated the results of a repair-oriented policy. All consecutive patients with congenital mitral valve disease who underwent surgery between 1996 and 2006 were studied retrospectively. Patients with atrioventricular canal, atrioventricular discordance, or ischemic regurgitation were excluded. During this period, 71 children (median age 2.9 years, range 3 days-20.8 years) underwent surgery. All but 1 underwent primary mitral valve repair. Twenty-two (30%) were younger than 12 months. Associated cardiac lesions were present in 45 children (63%) and were addressed concurrently in 35; previous cardiac procedures had been performed in 17 patients (24%). Mitral incompetence was predominant in 60 (85%) and stenosis in 11 (15%). During a median follow-up of 47.8 months (range 2-120 months), 14 patients underwent 17 mitral reinterventions: 14 repairs and 3 replacements. After 60 months, overall survival was 94% +/- 2.8%; freedoms from reoperation and prosthesis implantation were 76% +/- 5.6% and 94% +/- 3.6%, respectively. There were 4 deaths, and all survivors remain in New York Heart Association class I or II with moderate (6 patients) or less mitral dysfunction. Surgical repair of the congenital mitral valve can be successfully performed with low mortality, satisfactory valvular function at midterm follow-up, and acceptable reoperation rate while obviating risks associated with valvular prostheses. Suboptimal primary repair was significant predictor for reoperation but re-repair was often successful.

Abstract 2262: No Impact Of The Mitral Annuloplasty On Overall Survival In Patients With Ischemic Cardiomyopathy - Long-term Follow-up Study.

Good long-term results are reported after the mitral valve (MV) repair for ischemic regurgitation. The aim of the study was to identify predictors of the overall survival after routine MV repair in patients with ischemic cardiomyopathy. Methods. 164 patients, 60.9±8.66 years old, with chronic ischemic mitral regurgitation and left ventricle ejection fraction (EF) = 30.7±6.04 undergoing coronary bypass with or without MV repair were prospectively followed for 5.1±1.63 years. A Cox proportional hazards model evaluated overall survival as a function of baseline age, sex, EF, mitral regurgitation jet area, left atrial area, atrial fibrillation, NYHA class, prior anterior or inferior myocardial infarction, medical comorbidities, MV repair, left ventricular plasty, left main and 3 vessel disease, venous graft to left anterior descending artery, number of grafts and year of operation. Treatment selection bias was controlled by deriving a propensity score for mitral annuloplasty. Results. Predictors included in the Cox regression model of overall survival are presented in table . The ROC curve analysis revealed EF &lt;30.0, (sensitivity and specificity - 61.7% and 59.0%, respectively) and serum creatinine &gt;1.17, (45.6% and 77.2%) as a cut-off values in the prediction of overall survival. Conclusions. There is no impact of the mitral annuloplasty on overall survival in these patients. MV repair can be safely added to coronary bypass grafting in patients with ischemic cardiomyopathy. Multivariable Cox regression analysis results

Mitral valve repair or replacement in elderly people

Much has been published so far to describe and praise the benefits of mitral valve repair, and to compare it with valve replacement. Now, with mitral valve surgery in elderly people gaining greater acceptance worldwide, repair or replacement remains a controversial issue. This is especially true in the ageing population, in whom many of the complications associated with a mechanical valve can be avoided by using a bioprosthesis. This review will try to assess the latest views in the field and come up with possible answers to this ongoing question. The causes of mitral regurgitation in this age group are separately reviewed and discussed in the light of our better understanding of the pathophysiology of the disease. Mitral surgery is recommended when the effective regurgitant orifice reaches 40 mm. Repair in degenerative disease seems to be feasible, with good long-term results. In chronic ischaemic regurgitation, the concept of a tethered 'normal valve' is changing. The 'poor' ventricle may be able to withstand surgery as long as the subvalvular apparatus is preserved; on the other hand, repair and replacement seem to have the same survival advantage in high-risk patients. Mitral valve surgery is well tolerated in elderly people. Early intervention leads inevitably to better outcome. The majority of valvular disorders in this age group are amenable to repair, with good reproducible results. Replacement with a bioprosthesis remains a viable option for complex regurgitant jets.

The Clinical Development of Percutaneous Heart Valve Technology: A Position Statement of The Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), and the Society for Cardiovascular Angiography and Interventions (SCAI)

The Clinical Development of Percutaneous Heart Valve Technology: A Position Statement of The Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), and the Society for Cardiovascular Angiography and Interventions (SCAI)

The clinical development of percutaneous heart valve technology: A position statement of the Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), and the Society of Cardiovascular Angiography and Intervention (SCAI)

The clinical development of percutaneous heart valve technology: A position statement of the Society of Thoracic Surgeons (STS), the American Association for Thoracic Surgery (AATS), and the Society of Cardiovascular Angiography and Intervention (SCAI)

Estado actual de la cirugía mitral reconstructiva

Valve reconstruction, whenever technically feasible, is currently the treatment of choice for mitral valve regurgitation. Preoperative transesophageal echocardiography discloses the precise location and extent of these lesions, making it possible for the surgeon to determine the repairability of the valve and to devise a roadmap for the most appropriate surgical maneuvers. Today, the aim of surgery should not be limited to abolishing regurgitation, but should also comprise restoration of the normal valve geometry in order to ensure durability of the repair. This geometric redress involves a) leaflet enlargement or reduction, b) replacement of all ruptured, elongated or attenuated chords with Goretex sutures, and c) annuloplasty with a flexible, complete ring that prevents distension even in the intertrigonal area, maintains the saddle shape of the annulus and reduces the dilated anteroposterior diameter of the annulus. These techniques have made repair rates approaching 100% possible in patients with degenerative valve diseases. For functional ischemic regurgitation, treatment currently consists of reduction annuloplasty with a small complete ring performed at the time of revascularization. However, despite the improvements seen in these patients, late recurrence of insufficiency occurs in about 30% of them. Recent evidence that the mechanism of recurrence is the apical and lateral displacement of the papillary muscles suggests that in addition to annuloplasty, surgical approximation of the papillary muscles may be necessary.

Altered collagen concentration in mitral valve leaflets: biochemical and finite element analysis

Background. Ischemic mitral regurgitation or ventricular wall motion abnormalities will alter the stress distribution in the mitral valve. We hypothesize that in response, the regional collagen concentration will be altered and will significantly impact the stress distribution in the mitral valve. Methods. Two sheep served as normal (sham) controls. Two other sheep had coronary ligation resulting in abnormal ventricular wall motion. Four sheep underwent ligation to infarct the posteromedial papillary muscle, resulting in ischemic regurgitation. After 4 or 8 weeks, the mitral valves were excised, and the anterior leaflet sections were subjected to an assay for collagen concentration. Next, in a finite element model, to simulate changes in collagen concentration, the tissue stiffness was increased by 20%, and then decreased by 20%. In another model, the thickness of the tissue was increased by 20%, and then combined with decreased tissue stiffness. Physiologic loading pressures were applied, and leaflet stress, chordal stress, and coaptation results were analyzed. Results. The average collagen concentration in the normal sheep leaflets was 59.2% (dry weight), 50.6% in the ischemic controls, and 45.8% in the papillary muscle infarct group. Collagen concentration was greatest at the midline and decreased toward the commissures. Increased tissue stiffness resulted in increased leaflet and chordal stresses, as well as reduced coaptation. Decreased stiffness resulted in the opposite. Increased tissue thickness reduced leaflet and chordal stresses, but also reduced coaptation. The combination of increased tissue thickness and decreased stiffness demonstrated the greatest reduction in leaflet and chordal stress, while maintaining normal leaflet coaptation. Conclusions. The observed changes may demonstrate an early effort to compensate for increased leaflet stress. Microstructural alterations may demonstrate an early effort to compensate for altered physiologic loading to reduce stress and maintain coaptation. It is crucial in repairing or partially replacing thickened tissue that normal geometry and physiology be restored.