iRoot SP Sealers Research Articles

Reducing apical voids for intra-canal sealer injection using a modified passive deflation needle.

The aim of the study was to evaluate the ability of a modified passive deflation needle to reduce the apical voids during the intra-canal iRoot SP sealer injection. A modified passive deflation injection needle was designed. Forty 20°-curved and twenty S-shaped single-canal resin block models were allocated into six groups. Each group was mechanically prepared to #25/04 or #25/06 file; then the root canals were injected with iRoot SP sealer using a modified needle or a normal plastic needle. Radiographs were taken to measure the length of apical void in each specimen. Similarly, twenty single-canal extracted premolars were collected and randomly divided into four groups. Each group was prepared to #25/04 or #25/06 file; then the root canals were injected with iRoot SP sealer using a modified needle or a normal plastic needle. Roots were then scanned using micro-computed tomography (micro-CT), and the volume of voids in root canals was analyzed and compared among groups. Statistical analysis demonstrated that the length and the volumetric percentage of voids were much lower in the modified needle group in both resin block root canal models and extract teeth than the normal plastic needle group (P < 0.05). The modified passive deflation needle can efficiently reduce apical voids during the intra-canal iRoot SP sealer injection.

Quantitative evaluation of artifact expression in conebeam computed tomography of mesoporous calcium silicate nanoparticles as a promising root canal sealer

We aimed to quantitatively compare the area and volume of artifacts in cone beam computed tomography produced by mesoporous calcium silicate nanoparticles (MCSNs), AH Plus sealer, and iRoot SP sealer when used as root canal sealers. We prepared 40 single-rooted mandibular premolars and divided them into an MCSN sealer group, an AH Plus sealer group, an iRoot SP sealer group, and a no-sealer (control) group. We filled the canals with gutta-percha using the single-cone method and subjected them to conebeam computed tomography before and after the placement of root fillings using the same exposure parameters. We evaluated the images to quantify the areas of hyperdense and hypodense artifacts and non-affected teeth and reconstructed 3-dimensional image models of the materials to study volume distortion artifacts. The MCSN sealer group produced a significantly smaller hyperdense and volume distortion artifacts than the AH Plus and iRoot SP groups (P < .01), but the area and volume of hypodense artifacts did not differ significantly among the groups (P > .05). When used as a root canal sealer, MCSNs generate a significantly smaller area and volume of hyperdense artifacts than AH Plus and iRoot SP sealers. By significantly reducing the generation of high-density artifacts, MCSNs may facilitate the evaluation of root canal filling quality and the diagnosis of root canal abnormalities.

Clinical outcome of bioceramic sealer iRoot SP extrusion in root canal treatment: a retrospective analysis

BackgroundDuring the obturation procedure, sealer extrusion occurs in some cases. iRoot SP is a kind of bioceramic sealer with superior physicochemical and biological properties. This article reports the outcome of iRoot SP extrusion in root canal treatment and the potential factors associated with the outcome.MethodsNinety-nine patients and one hundred and eighty-five teeth treated between 2014 and 2020 were included in this retrospective study. All of the cases were filled with a single-cone technique and the iRoot SP sealer. The minimum follow-up visit period was 1 year. The outcome was evaluated by clinical examination and radiographic examination at recall and was classified as healed, healing (success), or not healed (failure).ResultsThe overall success rate of all teeth was 96.8%. The success rate of adequately filled teeth was 97.3%, while that of iRoot SP extrusion was 95.8%; the difference was not statistically significant. Factors such as gender, age, tooth position, follow-up visit period, size of periapical lesion, treatment type and extruding sealer amount had no influence on the outcome of iRoot SP extruded teeth.ConclusionsThe results suggested that iRoot SP extrusion has no adverse effect on the outcome of root canal treatment, which may contribute to the endodontic treatment.

Comparison of Residual Bioceramic and Epoxy Resin Sealers Following Retreatment with Reciprocating File System in Oval Root Canals: A Micro-computed Tomography Study

Introduction: When endodontic treatment has failed, non surgical retreatment is often the first choice. This procedure includes removal of previous obturating material followed by chemomechanical preparation, disinfection and refilling of the root canals. However, residual sealer during retreatment remains a concern when such bioceramic sealers are utilised for obturation and this can affect the prognosis. Aim: To evaluate and compare the amount of residual filling material after retreatment in straight and oval root canals filled with iRoot SP and AH Plus sealer using V-Blue file system using Micro-Computed Tomography (micro-CT). Materials and Methods: This in-vitro study was conducted at Bharati Vidyapeeth (deemed to be) Dental College and Hospital, Navi Mumbai, Maharashtra, India, between November 2020 to December 2021. Sixty freshly extracted human mandibular premolar with straight and oval canals standardised with Cone Beam Computed Tomography (CBCT) were prepared with ProTaper next files and were assigned to two groups for obturation with gutta-percha using AH Plus and iRoot SP sealer respectively. Quality of obturation was confirmed with CBCT. After one month, retreatment was carried with V-Blue files and percentage of remaining obturating material was were evaluated before and after retreatment through micro-CT imaging. Two sample means and Kolmogorov Smirnov test were used to analyse data. Results: Data of all the samples from the micro-CT evaluation indicated that the mean volume of the initial filling material did not differ significantly among AH Plus sealer and iRoot SP sealer group (p&gt;0.05). Percentage of residual volume of AH Plus sealer (0.02%) was lower than that of iRoot SP sealer group (0.06%) and this difference was statistically significant (p&lt;0.05). Conclusion: Considerable amount of iRoot SP sealer remained after retreatment using V-Blue file as compared with AH Plus sealer.

Confocal laser scanning microscopic evaluation of depth of penetration and Sealer/Dentin interface between endodontic sealers - An in-vitro study

An endodontic sealer contributes in obtaining an appropriate seal for the root canal system by establishing an association between the root canal walls and coronal restoration thereby promoting healing. This present research intended to compare the penetrating capacity and to determine sealer/dentin interface among various endodontic sealers. Horizontally sectioned tooth samples were obtained at 3 and 5mm and randomly divided into three groups: Group I - Chemically cured (AH Plus) sealer; Group II - Dual cured (EndoREZ) sealer; Group III – BioCeramic Nano sealer (iRoot SP). All three groups were coated with their respective sealers and obturated using cold lateral compaction technique. The samples were observed using Confocal Microscope for penetrating capacity evaluation and reviewing of sealer/dentin junction at 3 and 5mm depth. The results were statistically analyzed using one-way ANOVA and Tukey's Post-Hoc method. On depth of penetration evaluation, one-way ANOVA analysis showed Group II exhibited maximum depth of penetration in contrast to Group III and Group I. Group I showed the least average depth of penetration among the other two groups at both 3 and 5mm. On sealer/dentin interface evaluation at 3mm, Group II showed increased interface in comparison with to Group III and Group I. No statistical significance evident among the groups at 5mm. EndoREZ showed maximum depth of penetration in comparison with iRoot SP and AH Plus sealer at both 3 and 5mm. EndoREZ also showed significant sealer/dentin interface at the level of 3mm when compared to other sealers used.

Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles

Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues. To promote the antibacterial and sealing effects of a root canal filling, core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer, zinc oxide-eugenol(ZOE). The obtained CaO/ZnO particles had a size of 80–90 nm and a core-shell structure. The film thickness, flow rate, pH, and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested. The pH and calcium ion release results showed a slight increase in the prepared nanospheres, with a flow rate of 24.22 mm and a formed film thickness of 30 µm, which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials). Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05). A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nanospheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05). The core-shell structured CaO/ZnO nanosphere paste displayed excellent sealing and antibacterial properties, and it has promising application potential in endodontics.

Comparison of various sealers on postoperative pain in single-visit endodontics: A randomized clinical study

Aim: The aim of this study is to evaluate the effect of bioceramic-based sealers on postendodontic pain following single-visit endodontics. Materials and Methods: Ninety patients requiring primary endodontic treatment were selected for the study. Patients were treated in single visit endodontically using three different bioceramic-based sealers: Group 1: obturation done using mineral trioxide aggregate plus sealer, Group 2: obturation done using EndoSequence BC sealer, and Group 3: iRoot SP sealer. Postendodontic pain was measured for 48 h postoperatively. Results: No significant difference was found in postendodontic pain scores between the sealers groups. Conclusion: Postendodontic pain was reduced in all treatment groups. Any of the three bioceramic sealers can be used for single-visit endodontics without fear of postoperative pain.

Effect of root canal wall moisture and filling techniques on the sealability of iRoot sp

To study the effect of root canal wall moisture and filling techniques on the sealability of iRoot sp. Sixty-two undamaged extracted human single-rooted teeth with fully developed apex were selected and prepared by crown-down technique. Two teeth were selected randomly to observe dentin tubules, opening, the residual teeth were randomly assigned to 3 groups: group A (wet), group B (slightly moist),group C(dry).The roots were further divided into 4 subgroups, group a: iRoot sp sealer without a core material (bulk-fill); group b: iRoot sp sealer with single cone obturation techniques; group c: iRoot sp sealer with heated gutta-purcha vertical pressure; group d: iRoot sp sealer with cold gutta-percha lateral compression technique. Glucose microleakage were measured in each group by glucose oxidase method. The differences in distribution of each group were analyzed with SPSS 19.0 software package. Group A and group B always showed the maximum and minimum amount of glucose penetration in the whole experimental process, and the difference was statistically significant at 28d (P<0.05). Under the same degree of moisture of root canal wall, glucose leakage of subgroup Aa was significantly higher than that of subgroup Ab and Ac at 15 d; and significantly higher than Ab, Ac, Ad at 21 d and 28 d(P<0.05). In group B and C, the subgroups a, b, c, d had no significant difference from each other during the experimental process(P>0.05). iRoot sp sealer has the best sealing effect when root canals were slightly moist. When the root canal wall is completely dry or slightly moist, the sealability of iRoot sp bulk-fill is similar to that of iRoot sp sealer with gutta-percha filling technique.

Post-obturation pain following the use of carrier-based system with AH Plus or iRoot SP sealers: a randomized controlled clinical trial.

The aim of this study was to compare the postoperative pain after root canal treatment using a carrier-based obturation system and two different sealers. In this prospective randomized clinical trial, 160 patients were selected. Patients with vital and devital teeth were randomized into four groups using a randomized block design with block sizes of 10 patients each. The groups were devital/vital teeth treated with iRoot SP sealer and devital/vital teeth treated with AH Plus sealer. Patients were prescribed ibuprofen, a 200-mg analgesic, if needed, and postoperative pain was recorded by visual analogue scale at 6, 12, 24, and 72h after obturation. Pain score and frequency of tablet intake were recorded and statistically analyzed. Results showed that there was no significant difference between groups in the incidence of postoperative pain; however, iRoot SP sealer was associated with less analgesic intake compared to AH Plus sealer. The use of different sealers did not significantly affect pain levels. iRoot SP sealer was associated with less analgesic intake compared to AH Plus sealer.

In Vivo Comparative Evaluation of Periapical Healing in Response to a Calcium Silicate and Calcium Hydroxide Based Endodontic Sealers.

BACKGROUND:The composition of the root canal filling materials together with the apical limit of the root canal obturation affect the complete periapical healing after root canal therapy.AIM:This study was performed to evaluate and compare the periapical healing in response to calcium-silicate (iRoot SP) and calcium-hydroxide (Apexit) based-sealers.MATERIAL AND METHODS:Seventy-two upper premolars root canals of six dogs were used. The teeth were randomly assigned to four groups: Group one: roots were obturated using gutta-percha and Apexit-sealer; Group two: roots were obturated using gutta-percha&iRoot SP-sealer; Group three: the teeth were left open without obturation; Group four: where healthy teeth were used as a negative control. Teeth were evaluated after one, two and three months. The newly formed mineralised apical tissue and the periapical inflammatory infiltrate of the obtained photomicrographs were evaluated, and scorings were statistically-analysed.RESULTS:The mean percentage of the periapical inflammatory infiltrates and mineralisation scoring after one, two and three months evaluation period were not significantly different among the four groups (P > 0.05).CONCLUSIONS:Regardless of the sealer used, iRoot SP and Apexit promote healing of periapical tissues. IRoot SP sealer showed early insignificant more partial and almost full healing after two and three months.

Dentin Bond Strength Evaluation of Three Root Canal Sealers with Cold Gutta-Percha Lateral Obturation Technique: Push-Out Test Study

Aim: This study was designed to evaluate dentin bond strength by push-out test of three root canal sealers (IRoot SP, AH Plus, and MTA Fillapex endodontic sealers) with cold gutta-percha lateral obturation technique using push-out test. Methods: A total of 57 human freshly extracted mandibular premolar teeth for orthodontic reason were used in this study. All samples were decoronated 16±1mm from the apex and prepared using step-back technique up to master apical file # 40. The specimens were divided randomly into three groups (19 teeth each) according to the type of sealers used; Group 1(IRoot SP), Group 2(AH Plus sealer), and Group 3 (MTA Fillapex sealer). Each group was obturated with cold gutta-percha lateral obturation technique. The specimens were incubated for 7 days at 37oC with 100% humidity. Three sections of 2 mm thickness were obtained at 3, 7 and 11mm from the apex to represent apical, middle and coronal thirdrespectively. The push-out bond strength was determined for each root slice. Values were recorded, tabulated for each group and statistically analyzed. Results: IRoot SP showed the highest mean value of push-out bond strength (7.3±0.2), followed by AH Plus (6.8±0.1) while MTA Fillapex showed the lowest mean value of push-out bond strength (2.9±0.3). Conclusions: IRoot SP and AH plus sealers had greater resistance to push-out than MTA Fillapex sealer.

Influence of Warm Vertical Compaction Technique on Physical Properties of Root Canal Sealers

IntroductionThe aim of this study was to evaluate the influence of warm vertical compaction on the physical properties of root canal sealers. MethodsThe physical properties of 4 sealers (zinc oxide –eugenol [ZOE], AH Plus [Dentsply International, York, PA], RoekoSeal [Roeko/Coltene/Whaledent, Langenau, Germany], and iRoot SP [Innovative Bioceramix, Vancouver, Canada]) were tested. The setting time and flow of these sealers were measured at standard and high temperatures using ISO 6876 (2012) specifications. The percentage of voids in each sealer after complete setting at 37°C and 140°C was analyzed under a stereoscopic microscope. ResultsThe setting time of ZOE sealer increased significantly from 144.0 ± 4.1 minutes to 274.2 ± 7.4 minutes when the temperature increased from 37°C to 140°C, whereas there was a significant reduction in the other 3 sealers. At 37°C, the setting time of AH Plus, iRoot SP, and RoekoSeal was 543.8 ± 16.4, 245.8 ± 15.9, and 49.3 ± 1.5 minutes, and at 140°C the setting time decreased significantly to 12.9 ± 0.7, 14.2 ± 0.6, and 2.7 ± 0.4 minutes (P < .05). The flow of AH Plus increased when the temperature changed from 25°C to 140°C (P < .05), whereas the flow reduced for RoekoSeal and iRoot SP (for RoekoSeal from 24.8 ± 0.9 to 12.4 ± 1.3 mm and for iRoot SP from 22.9 ± 0.9 to 13.3 ± 1.5 mm) (P < .05). However, the flow of ZOE sealer was unaffected by the high temperature. ZOE sealer and iRoot SP exhibited a reduction of porosity at a high temperature (P < .05). ConclusionsWarm vertical compaction influenced some properties (the setting time, flow, and porosity) of 4 sealers. A significant reduction of setting time and flow was found in RoekoSeal and iRoot SP sealers at a high temperature.

Fracture resistance of roots obturated with a novel calcium silicate-based endodontic sealer (BioRoot RCS)

The aim of this ex vivo study was to evaluate the vertical-fracture resistance of roots obturated with a newly developed tricalcium silicate cement (BioRoot RCS; Septodont, Saint Maur Des Fosses, France) using cold lateral compaction technique (LC) or matched-taper single-cone gutta-percha technique (SC). Decoronated 82 single-rooted mandibular premolars were chemo-mechanically prepared and then randomly divided into 6 experimental groups (n = 12) and 2 control groups (n = 5): Group 1 iRoot SP-LC; Group 2 iRoot SP-SC; Group 3 MTA Fillapex-LC; Group 4 MTA Fillapex-SC; Group 5 BioRoot RCS-LC and Group 6 BioRoot RCS-SC. In the positive-control group, roots were instrumented but not filled, and in the negative-control group, roots were neither instrumented nor filled. All samples were incubated for two weeks and then subjected to vertical loading force (1 mm/min) until fracture. The force required to fracture each specimen were determined, and the data were statistically analyzed. The highest significant fracture resistance was recorded for the iRoot SP-LC, iRoot SP-SC, BioRoot RCS-LC, and BioRoot RCS-SC groups, with no significant difference among them (p > 0.05) when compared with the positive-control group (p < 0.05), whereas the lowest significant values were observed in the MTA Fillapex-LC and MTA Fillapex-SC groups (p < 0.05). The vertical fracture resistance of roots obturated with BioRoot RCS and iRoot SP sealers using either LC or SC technique was found to be similar to that of intact teeth. BioRoot RCS, newly developed tricalcium silicate cement, might have the potential to reinforce the instrumented teeth against vertical root fracture.

DYE EXTRACTION METHOD EVALUATION OF THE SEALING ABILITY OF THREE TYPES OF ENDODONTIC SEALERS

This study aimed to: evaluate the sealing ability of AH Plus sealer, IRoot SP sealer, and Epiphany-Resilon root canal filling system by Dye extraction method. Methods: 45 freshly extracted single rooted human teeth were instrumented with Revo-S; the sequence used was SC1, SC2, SU, AS30, AS35, and AS40 taper 0.06. The prepared specimens were then divided randomly into Negative controls (n = 9) and Positive controls (n = 9); the negative controls were completely covered with three layers of varnish, and the positive controls were enlarged, but not root filled. The remaining 27 teeth were then randomly divided into three groups of 9 teeth each according to the type of sealer used, as the following: Group 1 (AH Plus sealer), Group 2 (IRoot SP sealer), and Group 3 (Epiphany-Resilon root canal filling system). Apical leakage evaluation was done by dye extraction methods. Data were statistically analyzed. Results: The positive control showed total dye absorbance of 5000, while negative control samples had a low absorbance of 75. The mean absorbance values were 370, 315, and 400 for Group 1 (AH Plus), Group 2 (IRoot SP), and Group3 (Epiphany-Resilon root canal filling system) respectively. Conclusion: The three tested sealers had the similar capability in apical sealing.

Bond Strength of Calcium Silicate-Based Sealers to Dentine Dried with Different Techniques

Objective: To assess the influence of various canal-drying techniques on the push-out bond strength between radicular dentine and both MTA Fillapex and iRoot SP sealers. Materials and Methods: Eighty extracted single-root teeth were instrumented with ProTaper Universal rotary instruments to a size F4. The teeth were randomly assigned to 1 of 4 groups as follows: group 1, excess fluid in the canals was removed using a Luer vacuum adapter; group 2, the canals were dried with a single paper point; group 3, the canals were dried with 3-5 paper points, and group 4, the canals were rinsed with 95% ethanol and then dried with 3-5 paper points. In each group, the specimens were subgrouped according to root canal sealer into either subgroup A (MTA Fillapex) or subgroup B (iRoot SP sealer). Horizontal sections (thickness 1 ± 0.1 mm) were obtained from each specimen and a push-out test was performed using a universal testing machine at a crosshead speed of 1 mm/min on root slices. Statistical analysis was done using the Kruskal-Wallis test and Dunn's test for pair-wise comparisons. p < 0.05 was considered statistically significant. Results: Canals dried with only 1 paper point and obturated with the iRoot SP sealer (subgroup 2B) showed significantly higher bond strengths to the root canal wall compared to all other subgroups (p < 0.05), except for subgroup 1B (p > 0.05). Conclusions: The canal-drying technique influenced the adhesive bond strength between calcium silicate-based root canal sealers and the root canal wall.

The Effect of Smear Layer on Push - Out Bond Strength to Dentin of Bioceramic Sealer ( in Vitro Study )

Sealers should demonstrate adhesive properties to dentin, decreasing the chance of endodontic treatment failure. Increased adhesive properties to dentin may lead to greater strength of the restored tooth, which may provide greater resistance to tooth fracture and clinical longevity of an endodontically treated tooth. The aim of this study was to evaluate the shear bond strength of Bioceramic iRoot SP sealer, AH plus sealer and Apexit plus sealer in absence or presence of smear layer using push out bond strength test. Materials and Methods: Sixty straight single roots of the mandibular premolars were selected for this study. All canals were instrumented using ProTaper rotary instruments to achieve tapered canal walls, instrumentation was done with copious irrigation of 5.25% sodium hypochlorite. Roots were randomly divided into three groups according to the type of sealer used (twenty teeth for each group): Group A: Apexit plus + gutta percha, Group B: AH plus sealer + gutta percha, Group C: iRoot SP sealer + gutta percha .Then groups were subdivided according to types of final irrigation into two subgroups. Groups (A1, B 1, and C 1) were irrigated with 5 ml of 5.25% NaOCl for 1 minute while Groups (A2, B2, and C2), the smear layer was removed with 5 ml of 17% EDTA for 1 minute. All groups were rinsed with distilled water and then obturated with cold lateral condensation technique, the roots then stored in moist environment at 37°C for one week. The roots were embedded in clear acrylic resin and three horizontal sections were prepared at a thickness of 1 mm ±0.1 in the apical, middle and coronal parts of each root. The test specimens were subjected to the push-out test method using a Universal Test Machine that carried 1-mm, 0.5- mm and 0.3-mm plungers for coronal, middle and apical specimens, respectively. The loading speed was 0.5 mm/ min. The computer showed the higher bond force before dislodgment of the filling material. These forces were divided by the surface area to obtain the bond strength in MPa. Results: The results showed that the bond strengths of iRoot SP and AH Plus were significantly higher than those of Apexit plus, but there was no significant difference between the bond strength of iRoot SP and AH Plus.In terms of root segments, the bond strengths in the middle specimens and the apical specimens were higher compared with the bond strengths in the coronal specimens. Conclusion: The presence or absence of smear layer did not significantly affect the bond strength of Bioceramic filling materials.

Efficacy of ProTaper Universal Rotary Retreatment System for Gutta-percha Removal from Oval Root Canals: A Micro–Computed Tomography Study

IntroductionThe aim of this study was to use micro–computed tomography to evaluate the amount of remaining root filling material in oval canals filled by using 2 obturation techniques after retreatment with the ProTaper Universal Retreatment with or without solvent. MethodsForty mandibular incisor teeth with oval canals were prepared to the ProTaper Universal F3 and filled with gutta-percha and iRoot SP sealer by using continuous wave of condensation or cold lateral condensation techniques. The root fillings were removed with the ProTaper Universal Retreatment system, and the canals were prepared further with ProTaper F4. The operating time was measured. Preoperative and postoperative micro–computed tomography imaging was used to assess the percentage of volume of residual filling material in the canals. ResultsRemaining filling material was observed in all specimens. The mean volume of remaining material was higher in the continuous wave of condensation groups than in the cold lateral condensation groups, especially in the apical portions of the root canals (P < .05). The time required to reach a working length was significantly less in the solvent groups than in the nonsolvent groups (P < .05). However, in the nonsolvent groups, less time was required to achieve satisfactory gutta-percha removal and root canal refinement than in the solvent groups (P < .05). ConclusionsNone of the retreatment techniques were able to completely remove all gutta-percha/sealer from the oval canals. More root filling material was left in the root canals filled by using the continuous wave condensation technique than those filled by using the cold lateral condensation technique after retreatment. In the nonsolvent groups, less time was needed to achieve satisfactory gutta-percha removal and root canal refinement than in the solvent groups.

Resistance to Fracture of Roots Obturated with Novel Canal-filling Systems

Introduction This study was conducted to evaluate and compare the fracture resistance of roots obturated with various contemporary canal-filling systems. Methods Fifty single-rooted extracted mandibular premolars were decoronated to obtain 13-mm root segments. Ten roots were left unprepared and unfilled (negative control). Forty canals were instrumented using 0.06 taper EndoSequence files (Brassler, Savannah, GA). Roots were divided according to the obturating system into 4 groups (n = 10): group 1: iRoot SP sealer (Innovative Bioceramix, Vancouver, Canada) + ActiV GP cone (Brasseler USA, Savanah, GA), group 2: iRoot SP sealer + gutta-percha (GP), group 3: ActiV GP sealer + ActiV GP cone, and group 4: ActiV GP sealer + GP. All groups were obturated using single-cone technique. The roots within each group were embedded in acrylic molds and subjected to the fracture resistance test in which a compressive loading (0.5 mm/min) was applied until fracture. Data were statistically analyzed (analysis of variance and Tukey post hoc test). Results The significantly highest fracture resistance was recorded for both the negative control group (381.4 ± 53.2 N) and group 1 (iRoot SP sealer/ActiV GP cone [372 ± 62.9 N]) with no significant difference between them, whereas the significantly lowest value was reported in group 4 (ActiV GP sealer/GP cone [288.3 ± 30.5 N]). Conclusion Bioceramic-based sealer (ie, iRoot SP) is a promising sealer in terms of increasing in vitro resistance to the fracture of endodontically treated roots particularly when accompanied with ActiV GP cones.