Irish Setter Research Articles

Lung lobe torsion following intrathoracic surgery in a dog

AbstractA 6‐year‐old, male, neutered Irish Setter was presented for subacute onset of coughing/gagging, fever and lethargy. Computed tomography showed paraoesophageal nodules. Exploratory thoracotomy was performed with excision of three tracheobronchial lymph nodes, and the dog was discharged 2 days postoperatively. Seven days after thoracotomy, the dog developed tachypnoea and haemoptysis. A thoracic computed tomography was performed 14 days after thoracotomy, which revealed left caudal lung lobe torsion. At surgery, the lung lobe torsion was confirmed, and the left caudal lung lobe was excised. The dog was discharged 3 days postoperatively. Lung lobe torsion following thoracic surgery is more commonly reported in humans, and rarely occurs in dogs without prior lung lobectomy. This case report shows that lung lobe torsion can be a complication of thoracic surgery, even without prior lung lobectomy.

Hereditary gluten enteropathy in irish setters: evaluation of external parameters, clinical symptoms and fatal risks

Aim. Determine the features of appearance, clinical signs and fatal risks in Irish setters with hereditary gluten enteropathy. Methods. The methods used were observation, eye examination, clinical examination, autopsy, histological. Results. It has been established that in hereditary gluten enteropathy in Irish setters there are violations of the parameters of appearance, weak ability to train, fulminant and chronic forms of damage to the intestinal wall by type of enteropathy, anaphylactic reactions and cerebral disorders. In the dead setters, the causes of death were hypovolemic shock due to intestinal bleeding and combined critical injuries of the brain, heart and lungs. Conclusions. Violations of the parameters of appearance in setters with hereditary gluten enteropathy led to their unsuitability for hunting. Dietary therapy with the exclusion of feed containing cereals was effective in stabilizing the condition of sick setters. Setters with hereditary gluten enteropathy are at risk of developing fatal cardiovascular, pulmonary, and cerebral insufficiency. The validity of the spread of hereditary gluten enteropathy in Irish setters depends on the accounting of the results of multi-year studies by a multidisciplinary group of specialists.

Oesophageal adenocarcinoma presenting as a foreign body induced intrathoracic abscess in a dog

AbstractA 9‐year‐old, male, entire Irish setter was referred for further investigation of a chronic cough, anorexia, weight loss and lethargy. Computed tomography revealed a large ovoid encapsulated lesion, with a gas and fluid attenuating centre, and an intralesional mineral opacity. The lesion ran close to the caudal oesophagus, and extended cranially within the pulmonary parenchyma. Endoscopy revealed a communication between the lumen of the distal oesophagus and the lesion, which contained a purulent discharge and plant material. Based on the computed tomography and endoscopic findings, the diagnosis was expected to be a thoracic abscess, secondary to foreign body migration or penetration; however, surgical resection and histopathological analysis of the lesion revealed an oesophageal adenocarcinoma. This case details the unusual presentation of an oesophageal adenocarcinoma, with endoscopic and computed tomography findings that mimicked a thoracic abscess with an intralesional foreign body.

Irish Setters and Palestine Retrievers: Liberal Zionism in Beckett’s Watt Manuscripts

Samuel Beckett wrote Watt in occupied France. Its defining theme would be complicity. From the Watt manuscripts, we can glean insights into what Beckett was thinking as he tried to work through the rise of fascism and France’s capitulation to it. Central to that attempt was an artistic dialogue – vigorously comic but also rigorously ethical – with W. B. Yeats. Watt is, among other things, an Irish Big House novel, and it revolves around the problem of disposing of a landlord’s leftovers by way of a dog – or colony of famished dogs – bred for that purpose. This has been read as a parody of liberal political economy with its founding problem of waste. In the manuscripts, the ideal breed of dog for the task is a cross between an Irish setter and a Palestine retriever. I read this detail as a critique of the biopolitics of liberal Zionism, which Beckett understands as an aspect of the biopolitics of liberal colonialism more generally. Zionism’s early forays into Palestine were already enmeshed in the same colonial dynamics that had shaped the English occupation of Ireland. Characteristically, Beckett covered his tracks as he moved towards publication. But the manuscripts, written in the white heat of occupation, trace the emergence of his ethical response, both to Yeats’s incipient fascism and the liberal pretensions of the Zionist project.

Surgical treatment of colorectal tubular adenoma in dog

The surgical methods for treatment of adenomatous polyps in dogs and their effectiveness for maintaining health and quality of life of the animal were studied. The study was conducted on the clinical case of colorectal tubular adenoma (TA) surgical treatment in a 11-year-old male Irish setter who was admitted for hematochezia. A colonoscopy revealed a colon wall neoplasm. Based on the data of cytological and histological examination of the biopsy material, the patient was diagnosed with tubular adenoma of the rectum. Computed tomography revealed a mass 5718.318.3 mm in the rectal ampoule. After tissue segmentation, to make a therapeutic decision about the possibility of surgical resection and access, the ampoule of the rectum was resected through dorsal access. In the early postoperative period, tenesmus (with a decrease in their severity within a week after surgery) and partial fecal incontinence were recorded. The most serious complication was the formation of several more defects of the colon wall cranially from the superimposed anastomoses, which required three more operations. To decompress the colorectal anastomosis, a temporary flank double-barrelled colostomy with a support bridge was performed. The study revealed that despite the relatively rare incidence of TA in dogs, the comparison investigation of diagnosis and surgical treatment methods and avoiding postoperative complications and tumor recurrence is a relevant task both due to the possibility of TA malignancy and due to the fact that dogs are a naturally biological model for investigating this pathology.

Phenotypic characterization of idiopathic epilepsy and epilepsy of unknown cause in Irish Setters.

Canine epileptic seizures are common neurological symptom presenting to veterinary practice. Idiopathic epilepsy (IE) with a suspected genetic background has been reported in several dog breeds. Although it has been reported in the Irish Setter (IS), the phenotypic characteristics have not yet been described. The aim of this study was to characterize the phenotype of IE in this breed and to trace its mode of inheritance. Owners of IS were requested to fill in a questionnaire via the Dutch Irish Setter Club concerning the epileptic seizures in their dogs. The data was assessed retrospectively using descriptive statistics. Forty-eight privately owned IS dogs fulfilling tier I criteria for IE according to the International Veterinary Epilepsy Task Force of both sexes were included in the study. The mean age of seizure onset was 41 months. Five of the dogs included in the study had an onset of seizures >6 years of age. These dogs were classified with epilepsy of unknown cause (EUC). Primary generalized tonic-clonic seizures were the most common type of seizure and were seen in almost all dogs. Cluster seizures were reported in 54% of the studied population. Most owners reported pre- (56%) and post-ictal (97%) signs in their dogs. A pedigree analysis of one subpopulation was performed and traced the lineage of 13 affected IS. A segregation analysis of this population rejected a simple autosomal recessive inheritance pattern. The present study supports the occurrence of IE and EUC in the IS. The results provide clinical insight into epileptic seizures in this breed and may be a starting point for further, including genetic, analysis.

Histological and Immunohistochemical Features of Pulmonary Metastatic Oral Melanoma in a Labrador dog

Melanoma is a malignant tumour that originates from melanocytes. It has been reported in human beings as well as in many domesticated animal species (Reddy et al., 1998), and wild terrestrial and marine animals. Melanomas are the most commonly diagnosed malignant tumours in the oral cavity of canines (Goldschmidt, 1985; Faramade et al., 2017). Gingiva is the most common site for canine oral malignant melanoma (OMM) but other parts like palatine, labile or buccal mucosa also act as the sites of origin (Delverdier et al., 1991). It is generally an aggressive tumour, often locally invasive, and frequently metastasizes to regional lymph nodes and lungs but metastasis to other organs like the brain, heart, spleen, and liver is not common (Goldschmidt and Hendrick, 2002). Canine OMM accounts for about 7% of all malignant tumours of canine, 11.5% to 17.1% of all oral tumours (Mikiewicz et al., 2019), and 33% to 35.8% of all malignant oral tumours (Sarowitz et al., 2017). OMM is reported in old age group animals mainly ranging from 7 to 14 years age (Esplin, 2008). Most common breeds affected by OMM include Cocker Spaniels, Golden Retrievers, Dachshunds, mixed-breed dogs (Gillard et al., 2014) but histologically well-differentiated melanocytic neoplasms (HWDMN) also reported in Golden Retrievers, Labrador, Doberman Pinscher, Irish Setters, Cocker Spaniels, Beagles, etc. (Esplin, 2008). The diagnosis of melanoma is difficult mainly in tumors without appreciable melanin. Histological appearance resembles carcinoma, lymphoma, sarcoma, and osteogenic tumours. Therefore, immunohistochemistry with numerous melanoma specific markers is mostly used for confirmatory diagnosis in human and veterinary pathology (Wick, 2008). This case report is on the occurrence of oral melanoma with pulmonary metastasis in a Labrador dog.

Unerupted Supernumerary Mandibular Fourth Premolar in a dog.

A 2.5-year-old intact male Irish setter was presented for a draining tract associated with the right mandibular first molar tooth (409). Conscious oral examination yielded two draining tracts associated with the right mandibular first molar tooth. No obvious missing teeth or other gross abnormalities associated with the oral cavity were observed. Upon anesthetized radiographic evaluation, the presence of an unerupted, abnormally positioned, supernumerary premolar tooth was observed. The following article describes the extraction of the right mandibular first molar tooth (409) as well as the unerupted supernumerary premolar tooth with associated supernumerary root and the diagnostic approach taken for this uncommon abnormality.

Clinical conundrum

Abstract Laura Troth discusses a case of an Irish Setter with abdominal pain and pyrexia she saw when working as an intern at Highcroft Veterinary Referrals.

Five genetic variants explain over 70% of hair coat pheomelanin intensity variation in purebred and mixed breed domestic dogs.

In mammals, the pigment molecule pheomelanin confers red and yellow color to hair, and the intensity of this coloration is caused by variation in the amount of pheomelanin. Domestic dogs exhibit a wide range of pheomelanin intensity, ranging from the white coat of the Samoyed to the deep red coat of the Irish Setter. While several genetic variants have been associated with specific coat intensity phenotypes in certain dog breeds, they do not explain the majority of phenotypic variation across breeds. In order to gain further insight into the extent of multigenicity and epistatic interactions underlying coat pheomelanin intensity in dogs, we leveraged a large dataset obtained via a direct-to-consumer canine genetic testing service. This consisted of genome-wide single nucleotide polymorphism (SNP) genotype data and owner-provided photos for 3,057 pheomelanic mixed breed and purebred dogs from 63 breeds and varieties spanning the full range of canine coat pheomelanin intensity. We first performed a genome-wide association study (GWAS) on 2,149 of these dogs to search for additional genetic variants that underlie intensity variation. GWAS identified five loci significantly associated with intensity, of which two (CFA15 29.8 Mb and CFA20 55.8 Mb) replicate previous findings and three (CFA2 74.7 Mb, CFA18 12.9 Mb, CFA21 10.9 Mb) have not previously been reported. In order to assess the combined predictive power of these loci across dog breeds, we used our GWAS data set to fit a linear model, which explained over 70% of variation in coat pheomelanin intensity in an independent validation dataset of 908 dogs. These results introduce three novel pheomelanin intensity loci, and further demonstrate the multigenic nature of coat pheomelanin intensity determination in domestic dogs.

Suspected chronic subdural haemorrhage as a sequela of subdural empyema in an Irish Setter.

Journal of Small Animal PracticeVolume 62, Issue 8 p. 715-715 IMAGES IN SMALL ANIMAL PRACTICE Suspected chronic subdural haemorrhage as a sequela of subdural empyema in an Irish Setter L. Motta, Corresponding Author arsenicolupin_l@yahoo.it North West Veterinary Specialists, Delamere House, Ashville Point, Sutton Weaver, WA7 3FW UK Corresponding author email: arsenicolupin_l@yahoo.itSearch for more papers by this author L. Motta, Corresponding Author arsenicolupin_l@yahoo.it North West Veterinary Specialists, Delamere House, Ashville Point, Sutton Weaver, WA7 3FW UK Corresponding author email: arsenicolupin_l@yahoo.itSearch for more papers by this author First published: 30 March 2021 https://doi.org/10.1111/jsap.13335Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume62, Issue8August 2021Pages 715-715 RelatedInformation

A novel mutation in PDE6B in Spanish Water Dogs with early-onset progressive retinal atrophy.

To identify the underlying mutation in a recently identified early-onset progressive retinal atrophy (PRA) in the Spanish Water Dog (SWD) breed. Eighteen SWDs were used in this study. Six SWDs diagnosed with PRA and 12 phenotypically normal SWDs. An exclusion analysis using an established microsatellite panel to screen PRA candidate genes was combined with whole genome sequencing of two affected SWD siblings and two phenotypically normal SWDs (a sibling and the dam). A 6-bp deletion was identified in exon 19 of PDE6B removing two highly conserved amino acids from the enzymatic domain of the PDE6B protein (c.2218-2223del; p.Phe740_Phe741del). This segregated with the disease status in the small study pedigree. Identification of this novel PDE6B mutation adds to the already described PDE6B mutations responsible for PRA in the Irish Setter, Sloughi, and American Staffordshire Terrier dog breeds. A DNA-based test was designed to allow breeders to genotype their animals and make informed breeding decisions in the effort to eradicate PRA from the SWD breed.

Sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) in adult dogs: a retrospective analysis of 90 cases (2004-2018).

It has long been speculated that sterile granulomatous dermatitis and lymphadenitis (SGDL) occurs in adult dogs. However, only three published case reports exist. To describe clinical presentation, identify breed predispositions, and assess treatment and outcomes of adult dogs with the histopathological diagnosis of SGDL. Included are 90 dogs with biopsies submitted to a veterinary teaching hospital with a histopathological diagnosis consistent with SGDL, from 2004 to 2018, of which 35 had medical records available for review. Data were analysed retrospectively from histopathology submission forms, medical records, surveys and telephone calls. Scoring systems were created to aid statistical analysis of outcomes. Havanese dog (P<0.0001), Australian shepherd dog (P<0.0001), Irish setter (P<0.0001), Dachshund (P=0.0002), bichon frise (P=0.0003) and Maltese dog (P=0.004) were significantly over-represented breeds. The median age at onset was 1,292 days (3.54years). Dogs up to five years of age were significantly over-represented (P<0.01). Of 35 dogs with medical records available for review, the median treatment duration was 60days and the median time to remission 28days. Remission status was not established for five dogs but the remaining 30 dogs reached remission. Nineteen dogs remained in complete remission. Recrudescence occurred in 11 dogs (median follow-up 60 days). This study shows a close parallel in clinical appearance, histopathological results and clinical behaviour, of both adult and juvenile onset SGDL; therefore, SGDL should be considered as a differential diagnosis for dogs of all ages.

Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality within North American veterinary teaching hospitals.

To describe a large population of dogs with a diagnosis of hyperadrenocorticism at the time of death in North American veterinary teaching hospitals, and to identify comorbid conditions associated with hyperadrenocorticism. Retrospective cohort study of 1519 dogs with hyperadrenocorticism from a population of 70,574 dogs reported to the Veterinary Medical Database. Signalment, presence or absence of hyperadrenocorticism, aetiology of hyperadrenocorticism (if described), frequency of select comorbidities and causes of death were evaluated in dogs with and without hyperadrenocorticism. Hyperadrenocorticism was more frequent in females. Neutering was associated with a minor, but significant, increase in the odds of hyperadrenocorticism. Hyperadrenocorticism was the presumed cause of death of 393 (25∙9%) of affected dogs. When aetiology was specified (527 dogs, corresponding to 34∙7% of the cases), pituitary-dependent hyperadrenocorticism [387 (73∙4%) out of 527 dogs] was more common than functional adrenocortical tumour [136 (25∙8%) out of 527 dogs). Hyperadrenocorticism was over-represented in certain expected (miniature poodle, dachshund) and unexpected (Irish setter, bassett hound) breeds compared with the population at large. Of the select comorbidities investigated, dogs with hyperadrenocorticism were at increased risk for concurrent diabetes mellitus, urinary tract infection, urolithiasis, hypertension, gall bladder mucocoele and thromboembolic disease compared with dogs without hyperadrenocorticism. Hyperadrenocorticism is significantly associated with certain comorbid conditions but is not a major cause of mortality in affected dogs. Documented patterns now provide targets for prospective clinical research.

Identification of the mutation causing progressive retinal atrophy in Old Danish Pointing Dog.

Progressive retinal atrophy (PRA) is a common cause of blindness in many dog breeds. It is most often inherited as a simple Mendelian trait, but great genetic heterogeneity has been demonstrated both within and between breeds. In many breeds the genetic cause of the disease is not known, and until now, the Old Danish Pointing Dog (ODP) has been one of those breeds. ODP is one of the oldest dog breeds in Europe. Seventy years ago the breed almost vanished, but today a population still exists, primarily in Denmark but with some dogs in Germany and Sweden. PRA has been diagnosed in ODP since the late 1990s. It resembles late onset PRA in other dog breeds, and it is inherited as an autosomal recessive trait. In the present study, we performed whole-genome sequencing and identified a single base insertion (c.3149_3150insC) in exon 1 of C17H2orf71. This is the same mutation previously found to cause PRA in Gordon Setters and Irish Setters, and it was later found in Tibetan Terrier, Standard Poodle and the Polski Owczarek Nizinny. The presence of the mutation in such a diverse range of breeds indicates an origin preceding creation of modern dog breeds. Hence, we screened 262 dogs from 44 different breeds plus four crossbred dogs, and can subsequently add Miniature Poodle and another polish sheepdog, the Polski Owczarek Podhalanski, to the list of affected breeds.

Urinary incontinence in bitches under primary veterinary care in England: prevalence and risk factors.

To estimate prevalence and demographic risk factors for urinary incontinence in bitches under primary veterinary care in England. The study population included all bitches within the VetCompass database from September 1, 2009 to July 7, 2013. Electronic patient records were searched for urinary incontinence cases and additional demographic and clinical information was extracted. Of 100,397 bitches attending 119 clinics in England, an estimated 3108 were diagnosed with urinary incontinence. The prevalence of urinary incontinence was 3·14% (95% confidence intervals: 2·97 to 3·33). Medical therapy was prescribed to 45·6% cases. Predisposed breeds included the Irish setter (odds ratio: 8·09; 95% confidence intervals: 3·15 to 20·80; P< 0·001) and Dobermann (odds ratio: 7·98; 95% confidence intervals: 4·38 to 14·54; P< 0·001). Increased odds of a diagnosis of urinary incontinence were associated with: (1) weight at or above the mean adult bodyweight for the breed (odds ratio: 1·31; 95% confidence intervals: 1·12 to 1·54; P< 0·001), (2) age 9 to 12 years (odds ratio: 3·86; 95% confidence intervals: 2·86 to 5·20, P< 0·001), (3) neuter status (odds ratio: 2·23; 95% confidence intervals: 1·52 to 3·25, P< 0·001) and (4) being insured (odds ratio: 1·59; 95% confidence intervals: 1·34 to 1·88, P< 0·001). Clinical Impact: Urinary incontinence affects just over 3% of bitches overall but affects more than 15% of bitches in high-risk breeds including the Irish setter, Dobermann, bearded collie, rough collie and Dalmatian. These results provide an evidence base for clinicians to enhance clinical recommendations on neutering and weight control, especially in high-risk breeds.

Variation in activity levels amongst dogs of different breeds: results of a large online survey of dog owners from the UK.

Regular physical activity is an important means of promoting health, both in people and their pets. Walking is the most common method used for dogs, but there is a lack of clarity on how much daily activity different breeds of dog require. Data from an online survey of UK dog owners were collected between June and August in 2014. The University of Liverpool Ethics Committee approved the project, and owners consented to data use. The initial dataset (17028 dogs) was first cleaned to remove erroneous data, and then edited to remove mixed breed dogs, leaving a total of 12314 dogs from known pedigree breeds. Other information collected included sex, age, neuter status, breed, and amount and frequency of exercise. Exercise frequency and duration were estimated across different breeds, and compared with Kennel Club recommendations, using χ2 tests and binary logistic regression. The online survey data indicated differences amongst breeds in the amount of walking reported (P<0·001). Afghan hounds were the least exercised breed, whilst breeds reportedly exercised most included: English setter, foxhound, Irish setter and Old English sheepdog. Gundogs were most likely to be walked once per d or more (P<0·001), whilst smaller dogs were more likely to meet their UK Kennel Club guidelines for dog walking (P<0·001). The frequency of dog walking varies both within and amongst breeds, and many do not currently receive the recommended amount of exercise. This may constitute a canine welfare problem and also have an impact on the physical activity levels of their owners.

Frequentieschatting van ziekteveroorzakende mutaties in de Belgische populatie van enkele hondenrassen: Deel 2: retrievers en andere rastypes

De Belgische populatie van tien hondenrassen (de bichonfrisé, sint-hubertushond, Vlaamse koehond, boxer, cavalier-kingcharlesspaniël, Ierse setter, het vlinderhondje, de rottweiler, golden retriever en labrador-retriever), waarvan de genetische diversiteit in België laag tot middelmatig laag is of die relatief populair zijn, werd gegenotypeerd voor ziekteveroorzakende mutaties die potentieel relevant zijn voor deze rassen. Op deze manier werd de frequentie van 26 mutaties geschat om zo gerichter fokadvies te kunnen geven. Aandoeningen waarvan de frequentie hoog genoeg ligt om routine-genotypering aan te raden in fokprogramma’s zijn (1) degeneratieve myelopathie voor de sint-hubertushond, (2) “arrhythmogenic right ventricular cardiomyopathy” en degeneratieve myelopathie voor boxers, (3) “episodic falling syndrome” en macrothrombocytopenie voor de cavalier-kingcharlesspaniël (4) progressieve retina-atrofie “rod-cone” dysplasie 4 voor de Ierse setter, (5) golden retriever progressieve retina-atrofie 1 voor de golden retriever en (6) “exercise induced collapse” en progressieve “rod-cone” degeneratie voor de labrador-retriever. De aanwezigheid van de oorzakelijke mutatie voor een korte staart bij de Vlaamse koehond wordt hier volgens de auteurs voor het eerst beschreven.

Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission

Metaphyseal osteopathy (MO) (hypertrophic osteodystrophy) is a developmental disorder of unexplained etiology affecting dogs during rapid growth. Affected dogs experience relapsing episodes of lytic/sclerotic metaphyseal lesions and systemic inflammation. MO is rare in the general dog population; however, some breeds (Weimaraner, Great Dane and Irish Setter) have a much higher incidence, supporting a hereditary etiology. Autoinflammatory childhood disorders of parallel presentation such as chronic recurrent multifocal osteomyelitis (CRMO), and deficiency of interleukin-1 receptor antagonist (DIRA), involve impaired innate immunity pathways and aberrant cytokine production. Given the similarities between these diseases, we hypothesize that MO is an autoinflammatory disease mediated by cytokines involved in innate immunity. To characterize immune dysregulation in MO dogs we measured serum levels of inflammatory markers in 26 MO and 102 control dogs. MO dogs had significantly higher levels (pg/ml) of serum Interleukin-1beta (IL-1β), IL-18, IL-6, Granulocyte-macrophage colony stimulating factor (GM-CSF), C-X-C motif chemokine 10 (CXCL10), tumor necrosis factor (TNF), and IL-10. Notably, recovered MO dogs were not different from dogs during active MO disease, providing a suggestive mechanism for disease predisposition. This is the first documentation of elevated immune markers in MO dogs, uncovering an immune profile similar to comparable autoinflammatory disorders in children.

Malignant Metastatic Insulinoma in a Dog

Background: Insulinomas are tumors of the pancreatic islet beta cells that secreting insulin. They are malignant neoplasms and rarely seen in dogs. Because insulinomas secrete excessive insulin and hypoglycemia occur. The most common clinical symptoms are seizures, extreme weakness, and other neurological abnormalities. The tumors typically release insulin episodically, with clinical signs being seen intermittently as a result. These are most often associated with prolonged starvation or prolonged periods of exertion. Insulinoma occurs most often in middle-aged and older dogs, averaging nine years in age. They affect both sexes and are more likely in larger breeds. The most commonly afflicted breeds are German Shepherds, Irish Setters, Boxers, Golden Retrievers and Terriers. Case: In this study, a case of malignant insulinoma with multiorgan metastasis in a 7-year-old hunting dog that brought to the clinic with complaints of constipation and inappetence were evaluated by clinical, cytological, histopathological and immunohistochemical fndings. Owner stated that the animal suffers from constipation for 4 days, but no vomitus or nervous symptoms were present. Clinical efforts not solved the constipation. For to the defnitive diagnosis the dog decided to underwent laparotomy. After a midline abdominal approach multiple whitish, hard and irregular metastatic tumoral masses were observed in different abdominal organs. Because of the poor prognosis and according to owner’s acceptance the dog euthanatized at the same time. At necropsy, a bloody serous fluid approximately 500 mL was found in the abdominal cavity. The intestines were hyperemic and hemorrhagic in some areas. A hemorrhagic 9x5x3 cm in diameter mass was observed on the pancreas. Mesenterial adhesions were formed due to mass between duodenum and jejunum. The mass was moderately hard and cut surface was bloody, necrosis was observed in some areas. At the gross examination, whitish color, various sized and multiple metastatic masses were noted in spleen, liver, lymph nodes and lungs. Before formalin fxation, impression smears were made from the pancreatic mass. In cytological preparations of the lesion, epithelial cells in different shapes and sizes were observed. At the histopathological examination, the tumor mass consisted of anaplastic, pleomorphic cells that have pale cytoplasm, vesicular nucleus and prominent nucleolus. Diffuse necrotic areas were noted in the mass. Similar metastatic masses were seen in liver, spleen, lungs and kidneys. The tumor cells were positive for insulin and negative for glucagon immunohistochemically. Discussion: Insulinomas generally caused nervous symptoms due to hypoglycemia. Metastasis may occur in some cases and generally lymph node metastasis occurs. Spleen metastasis are very rare in insulinoma cases. The mean age of the occurrence of insulinoma is generally older than 9-year-old. In this case, a case of malignant insulinoma with multiorgan metastasis and caused constipation due to intestinal adhesions in a dog was presented with clinical and pathological fndings. Best of the author’s knowledge insulinoma as a cause of constipation not previously reported in a dog. The aim of this study was to report a case of metastatic insulinoma without neurological symptoms but constipation in a 7 years old hunting dog by clinical, pathological, cytological and immunohistochemical fndings. Keywords: Malignant insulinoma, constipation, cytology, histopathology, immunohistochemistry, dog.