The Republic of Ireland has undergone a seismic religious and social transformation in recent decades. Through the processes of secularization and detraditionalization, as well as several major scandals within the Irish Catholic Church, irreligiosity has become an increasing reality in terms of the hitherto overwhelmingly Catholic population. At a time of spiritual climate change in this post-Catholic Ireland, the contemporary phenomenon of mindfulness has exploded in popularity across various elements of society. Against this backdrop, three distinctive modes or strands of mindfulness are proposed as being operative in the Irish context, each catering to the needs of different practitioners. The proposed modes include psychological and clinical mindfulness and commodified and post-secular spirituality. Within the lacuna created by the receding of Catholic belief and practice, the emergence of mindfulness in the Irish context is explored, mapping how this originally Buddhist practice has gained such a foothold in contemporary spiritual discourse.