Iris Aperture Research Articles

An integrated 3D printed radioluminescent-based phantom for quality assurance on a robotic-arm linac

Objective. To develop, characterize and improve upon a high-resolution 3D printed radioluminescence-based imaging phantom for quality assurance (QA) of a robotic arm linear accelerator. Approach. A phantom was constructed which consisted of a scintillating sheet, fiducial markers, a low-cost complementary metal-oxide semiconductor camera and a 3D printed light–tight enclosure. The camera, equipped with a 12 mm lens, was angled 45 degrees from the horizontal axis with a direct line of sight of the scintillating sheet. A perspective image transformation with optical distortion correction was employed to obtain beam’s eye view images for different collimators. Beam profiles, Iris™ field size, multileaf collimator leaf positioning and central laser-radiation field coincidence QA tests were performed and compared against data obtained with gafchromic film. The phantom’s short-term stability, sensitivity to changes in output, field size and leaf positioning were also assessed. Main Results. The limiting resolution of the optical system was measured to be ∼0.26 mm. Field size, as measured by the radioluminescence system for Iris apertures, agreed to within 0.2 mm of the values measured using film. The imaging system was sensitive to field size changes well below 0.2 mm and output changes as small as 1 monitor unit (MU). For the optical setup, the mean leaf deviation error for banks X1 and X2 was 0.21 and 0.17 mm at 800 mm source to axis distance, whereas the mean difference for the film dataset was 0.16 mm and 0.22 mm for banks X1 and X2, respectively. The optical system was able to detect leaf positioning errors as small as 0.2 mm. Compared with film data, excellent agreement was seen for relative central axis beam profiles for 10 mm and 5 mm beams. Significance. The phantom presented here is an alternative to film and electronic portal imager devices, due to its low-cost, portability, and high spatial and temporal resolution.

Characterization of a Gd-based color CMOS detector for proton dosimetry

A color scintillation detector for relative dose distribution measurement was developed at PSI. The system consists of a gadolinium-based scintillating screen mounted perpendicularly to the beam axis and coupled with a color CMOS camera in a light-tight box. The camera is equipped with an iris (aperture) controller to remotely adjust the number of photons reaching the image sensor. To improve the measurement accuracy and decrease the image artifacts, we investigated different methods for spatial calibration and optimized the internal light reflection by adjusting the detector structure. The response dependence on camera working distance, iris setting, and color channels was assessed. The depth-dose curves of the gadolinium-based scintillator in three RGB channels were compared with reference curves measured by an Advanced Markus plane-parallel ion chamber. The quenching effect of the ▪ screen measured with this system amounts to about 10% in the Bragg peak region of a 150 MeV proton beams. The shape of the emission spectrum was observed to be independent of the ionization density. Preliminary investigations showed that it is possible to correlate the ratio of the detector response in different color channels with the proton ionization density.

Angle-dependence of ADF-STEM intensities for chemical analysis of InGaN/GaN

In this paper we perform angular resolved annular-dark field (ADF) scanning-transmission electron microscopy (STEM) to study the scattered intensity in an InGaN layer buried in GaN as a function of the scattering angle. We achieved angular resolution with a motorized iris aperture in front of the ADF detector. Using this setup, we investigated how the intensities measured in various angular ranges agree with multislice simulations in the frozen-lattice approximation. We observed a strong influence of relaxation induced surface-strain fields on the ADF intensity, measured its angular characteristics and compared the result with simulations.To assess the agreement of the measured intensity with simulations, we evaluated the specimen thickness in GaN and the indium concentration in InGaN for each angular interval by comparing the measured intensities with simulations. The thickness was strongly overestimated for scattering angles below 40mrad and also the evaluated indium concentration varies with the considered angular range. Using simulations, we investigated which angular ranges show a high sensitivity to variations of the thickness and which intervals strongly depend on the indium concentration. By combining two angular intervals, the indium concentration and the specimen thickness were determined simultaneously, which has potential advantages over the usual quantification method. It is shown that inelastic scattering, surface contamination and mistilt can have an influence on the measured intensity, especially at lower scattering angles below 30–50mrad, which might explain the observed difference between the frozen lattice simulation and the experiment.

Motor-driven autonomous system for controlling beamline iris diaphragm apertures

At the collinear apparatus for laser spectroscopy and applied sciences (COALA) at TU Darmstadt, collinear laser spectroscopy is applied to perform high-precision measurements of atomic transition frequencies and high voltages in an ultra-high vacuum beamline. In such laser spectroscopy beamlines, iris diaphragms are used to reduce ion beam divergence, and to ensure a good laser and ion beam overlap. Since the system that controls the diameter of the apertures presents strong hysteresis, an automated adjustment is desirable to enhance reproducibility in the aperture settings, and to reduce the effort in performing measurements where different diameters are required, especially in alternating collinear and anti-collinear measurements. To achieve this, the Iris Mover system was designed and implemented. The Iris Mover system consists of motor-driven iris apertures which can be easily controlled by users through a computer, and which accounts for hysteresis effects. Here, we explain the design process of the Iris Mover and demonstrate and discuss its functionality.

Angle-resolved STEM using an iris aperture: Scattering contributions and sources of error for the quantitative analysis in Si

The angle-resolved electron scattering is investigated in scanning-transmission electron microscopy (STEM) using a motorised iris aperture placed above a conventional annular detector. The electron intensity scattered into various angle ranges is compared with simulations that were carried out in the frozen-lattice approximation. As figure of merit for the agreement of experiment and simulation we evaluate the specimen thickness which is compared with the thickness obtained from position-averaged convergent beam electron diffraction (PACBED). We find deviations whose strengths depend on the angular range of the detected electrons. As possible sources of error we investigate, for example, the influences of amorphous surface layers, inelastic scattering (plasmon excitation), phonon-correlation within the frozen-lattice approach, and distortions in the diffraction plane of the microscope. The evaluation is performed for four experimental thicknesses and two angle-resolved STEM series under different camera lengths. The results clearly show that especially for scattering angles below 50 mrad, it is mandatory that the simulations take scattering effects into account which are usually neglected for simulating high-angle scattering. Most influences predominantly affect the low-angle range, but also high scattering angles can be affected (e.g. by amorphous surface covering).

Analytic RF design of a linear accelerator with a SLED-I type RF pulse compressor

This study presents the RF design of a linear accelerator (linac) operated in single-bunch mode. The accelerator is powered by a compressed RF pulse produced from a SLED-I type RF pulse compressor. The compressed RF pulse has an unflattened shape with a gradient distribution which varies over the structure cells. An analytical study to optimize the accelerating structure together with the RF pulse compressor is performed. The optimization aims to maximize the efficiency by minimizing the required RF power from the generator for a given average accelerating gradient. The study shows that, owing to the compressed RF pulse shape, the constant-impedance structure has a similar efficiency to the optimal structure using varying iris apertures. The constant-impedance structure is easily fabricated and is favorable for the design of a linac with a pulse compressor. We utilize these findings to optimize the RF design of a X-band linac using the constant-impedance accelerating structure for the Tsinghua Thomson X-ray source facility.

Keratoconic eyes with stable corneal tomography could benefit more from custom intraocular lens design than normal eyes

We investigated whether eyes with keratoconic corneal tomography pattern could benefit more from aberration correction with custom intraocular lenses (IOLs) than normal cataractous eyes despite the effect of misalignment on the correction of aberrations. Custom IOLs (cIOLs) were calculated for twelve normal and twelve keratoconic eyes using personalized numerical ray tracing models. The Stiles-Crawford weighted root-mean-square spot-size (wRMS) at the virtual fovea was evaluated for cIOLs and aberration-neutral IOLs (nIOLs) in a simulated clinical study with 500 virtual IOL implantations per eye and per IOL. IOL misalignment (decentration, tilt, rotation) and pupillary ectopia (4.5 mm iris aperture) were varied upon each virtual implantation. The nIOLs achieved average wRMS of 16.4 ± 4.3 μm for normal, and 92.7 ± 34.4 μm for keratoconic eyes (mean ± standard deviation). The cIOLs reduced the average wRMS to 10.3 ± 5.8 μm for normal, and 28.5 ± 18.6 μm for keratoconic eyes. The cIOLs produced smaller wRMS than nIOLs in most virtual implantations (86.7% for normal and 99.4% for keratoconic eyes). IOL misalignment resulted in larger wRMS variations in the keratoconus group than in the normal group. Custom freeform IOL-optics-design may become a promising option for the correction of advanced aberrations in eyes with non-progressive keratoconic corneal tomography pattern.

Commissioning of two different algorithms for stereotactic Radiosurgery M6 FI+ CyberKnife system

Introduction: Cyber Knife M6 FI+ a very precise robotic stereotactic radiosurgery system which is capable of delivering very high radiation dose to the tumour while minimizing radiation exposure to normal organs and tissues. MultiPlan treatment planning system is used with the CyberKnife unit and the algorithms used for optimization are Ray-Tracing and Monte Carlo. Our CyberKnife M6 FI+ system commissioning is done as per the vendor recommendation and meeting the local regulatory guidelines. Materials and Methods: Clinical beam data measurement is carried out using Radiation Field Analyzer, Diode E, Pinpoint chamber, Semiflex ionization chamber and Unidose E Electrometer. FC-65 ionization chamber used in absolute dose calibration. The mechanical accuracy of the robot and image stability was verified using Radiochromic film (EBT3), E2E and Iris QA toolkits along with software. StereoPHAN is used for the patient-specific QA point dose measurement. Results: Tissue phantom ratio, Off-centre ratio, Output factor, Percentage depth dose, open beam profile and absolute dose calibration are done as per the protocols. E2E performed for two different modes- static and motion. Iris aperture size measured for all the field sizes. The patient-specific QA delivered for both algorithms. Discussion: Clinical beam data measurements are within ±1% of composite data set, overall standard deviation for Output Factors of the fixed and Iris collimators are 0.0026 and 0.0063. The absolute dose was calibrated to 1cGy per MU. E2E, Iris QA and Laser and radiation coincidence values are within the tolerance. Patient-specific QA point dose measurement variation for Ray-Tracing and Monte Carlo is 3% and 2%. Conclusion: These exercises are mandatory to achieve the accurate, precise and high quality of treatment which also includes patient safety.

Residual Iris Retraction Syndrome After Artificial Iris Implantation

To evaluate the effect of an artificial iris implant on the remnant iris. Interventional case series. Setting: Single center. Forty-two consecutive patients. Morphologic evaluation over 24 ± 14months. Remnant pupillary aperture, iris color, visual acuity, intraocular pressure, and endothelial cell count. In 7 of 42 cases (16.7%), the residual iris aperture dilated from 36.6 ± 15.4mm2 preoperatively to 61.1 ± 12.5mm2 1 year postoperatively (66.9% increase). In 5 of 7 affected eyes the artificial iris had been implanted into the ciliary sulcus; in 2 eyes it had been sutured to the sclera. Four of the 7 patients presented with remarkable complications: 2 eyes needed glaucoma shunt surgeries owing to pigment dispersion; 1 suffered from recurrent bleedings; and in 1 case artificial iris explantation was performed owing to chronic inflammation. Anterior chamber depth and angle, endothelial cell count, and visual acuity did not change in this cohort. Changes in color were not observed in the remnant iris. The implantation of an artificial iris prosthesis can lead to a residual iris retraction syndrome. It is likely that residual iris is trapped in the fissure between the artificial iris and the anterior chamber angle, preventing further pupil constriction. Another possibility could be a constriction or atrophy of the residual iris. A scleral-sutured implant and an implantation in the capsular bag were both found to prevent the iris retraction. The study group number is inadequate to allow statistical comparison of these different implantation methods. As the use of artificial irises increases, we may expect more patients with iris retraction syndrome in the future.

CyberKnife® fixed cone and Iris™ defined small radiation fields: Assessment with a high-resolution solid-state detector array.

PurposeThe challenges of accurate dosimetry for stereotactic radiotherapy (SRT) with small unflattened radiation fields have been widely reported in the literature. In this case, suitable dosimeters would have to offer a submillimeter spatial resolution. The CyberKnife® (Accuray Inc., Sunnyvale, CA, USA) is an SRT‐dedicated linear accelerator (linac), which can deliver treatments with submillimeter positional accuracy using circular fields. Beams are delivered with the desired field size using fixed cones, the InCise™ multileaf collimator or a dynamic variable‐aperture Iris™ collimator. The latter, allowing for field sizes to be varied during treatment delivery, has the potential to decrease treatment time, but its reproducibility in terms of output factors (OFs) and dose profiles (DPs) needs to be verified.MethodsA 2D monolithic silicon array detector, the “Octa”, was evaluated for dosimetric quality assurance (QA) for a CyberKnife system. OFs, DPs, percentage depth‐dose (PDD) and tissue maximum ratio (TMR) were investigated, and results were benchmarked against the PTW SRS diode. Cross‐plane, in‐plane and 2 diagonal dose profiles were measured simultaneously with high spatial resolution (0.3 mm). Monte Carlo (MC) simulations with a GEANT4 (GEometry ANd Tracking 4) tool‐kit were added to the study to support the experimental characterization of the detector response.ResultsFor fixed cones and the Iris, for all field sizes investigated in the range between 5 and 60 mm diameter, OFs, PDDs, TMRs, and DPs in terms of FWHM measured by the Octa were accurate within 3% when benchmarked against the SRS diode and MC calculations.ConclusionsThe Octa was shown to be an accurate dosimeter for measurements with a 6 MV FFF beam delivered with a CyberKnife system. The detector enabled real‐time dosimetric verification for the variable aperture Iris collimator, yielding OFs and DPs consistent with those obtained with alternative methods.

Beam Commissioning Data Acquisition for the Iris Variable Aperture Collimator of CyberKnife VSI

Objective: To minimize the risk inherent to the use of medical radiation and robotic radiosurgery, this research introduced the basis and method of beam commissioning data acquisition for the Iris variable aperture collimator of CyberKnife VSI. Methods: In this study, clinical dosimetry measurements of the Iris collimator such as tissue-phantom ratios (TPRs), off-center ratios (OCRs), and secondary collimator output factors (OFs) were conducted, and the data was contrasted with that of the Fixed collimator. Results: The Iris data and the Fixed data were not quite different in TPRs in the same radiation field size. Since the difference of the hardware structure,the OCRs and OFs were quite different, especially in small aperture (5, 7.5 and 10 mm) under the same condition of SAD. For example, the maximum discrepancy of the OFs was 26.67% (5mm aperture, 650mm SAD). Conclusion: When Iris aperture makes some change, tungsten segments move fast and form an aperture smaller than that we need, and then recover to the right size, which may affect the results of the measurement, and also the dodecagonal design of Iris results in a problem of leakage radiation on the edge. Keywords: Beam commissioning, Iris Variable Aperture Collimator, tissue phantom ratio, off center ratio, output factor, CyberKnife VSI™.

C -band disk-loaded-type accelerating structure for a high acceleration gradient and high-repetition-rate operation

A high-acceleration-gradient linear accelerator (LINAC) for an x-ray free electron laser (XFEL) offers the advantages of a short accelerator length and low construction costs. In addition, the high pulse repetition rate of the LINAC, which can drive multiple x-ray beam lines, provides additional user opportunities for experiments involving XFEL. A $C$-band disk-loaded-type accelerating structure was developed to achieve a high acceleration gradient of $g50\text{ }\text{ }\mathrm{MV}/\mathrm{m}$ and an rf-pulse repetition rate of 120 pps, which is twice as high as that of the XFEL facility, SACLA (60 pps). The structure has a quasiconstant gradient and a traveling wave type with an accelerating mode of $\mathrm{TM}01\ensuremath{-}2\ensuremath{\pi}/3$. To reduce the surface electric fields, we employed a cross section with an ellipsoidal curvature around an iris aperture. The accelerating structure was manufactured for SACLA. High-power rf conditioning was conducted to investigate its performance. Owing to the conditioning, the acceleration gradient reached a value of more than $50.1\text{ }\text{ }\mathrm{MV}/\mathrm{m}$. The structure was operated without any serious issues at a repetition rate of 120 pps. The accelerating structures were installed in the dedicated accelerator for EUV-FEL at SACLA beam line-1. Finally, we obtained accelerated electron beams with the structures operated at an acceleration gradient of $41.4\text{ }\text{ }\mathrm{MV}/\mathrm{m}$.

A Novel Method for Quality Assurance of the Cyberknife Iris Variable Aperture Collimator.

Objective: To characterize a novel method for field-size quality assurance of a variable approximately circular aperture collimator by means of dose-area product measurements and to validate its practical use over two years of clinical application.Methods: To assess methodical limitations, we analyze measurement errors due to change in linac output, beam tuning, uncertainty in MU delivery, daily factors, inherent uncertainty of the large-area parallel-plate ionisation chamber, and misalignment of the large-area parallel-plate ionisation chamber relative to the primary beam axis. To establish a baseline for quality assurance, the dose-area product is measured with the large-area parallel-plate ionisation chamber for all 12 clinical iris apertures in relation to the 60 mm fixed reference aperture. To evaluate the long-term stability of the Iris collimation system, deviation from baseline data is assessed monthly and compared to a priori derived tolerance levels.Results: Only chamber misalignment, variation in output, and uncertainty in MU delivery contribute to a combined error that is estimated at 0.2 % of the nominal field size. This is equivalent to a resolution of 0.005 mm for the 5 mm, and 0.012 mm for the 60 mm field. The method offers ease of use, small measurement time commitment, and is independent of most error sources. Over the observed period, the Iris accuray is within the tolerance levels.Conclusions: The method is an advantageous alternative to film quality assurance with a high reliability, short measurement time, and superior accuracy in field-size determination.

An investigation of kV CBCT image quality and dose reduction for volume-of-interest imaging using dynamic collimation.

The focus of this work was to investigate the improvements in image quality and dose reduction for volume-of-interest (VOI) kilovoltage-cone beam CT (CBCT) using dynamic collimation. A prototype iris aperture was used to track a VOI during a CBCT acquisition. The current aperture design is capable of 1D translation as a function of gantry angle and dynamic adjustment of the iris radius. The aperture occupies the location of the bow-tie filter on a Varian On-Board Imager system. CBCT and planar image quality were investigated as a function of aperture radius, while maintaining the same dose to the VOI, for a 20 cm diameter cylindrical water phantom with a 9 mm diameter bone insert centered on isocenter. Corresponding scatter-to-primary ratios (SPR) were determined at the detector plane with Monte Carlo simulation using EGSnrc. Dose distributions for various sizes VOI were modeled using a dynamic BEAMnrc library and DOSXYZnrc. The resulting VOI dose distributions were compared to full-field distributions. SPR was reduced by a factor of 8.4 when decreasing iris diameter from 21.2 to 2.4 cm (at isocenter). Depending upon VOI location and size, dose was reduced to 16%-90% of the full-field value along the central axis plane and down to 4% along the axis of rotation, while maintaining the same dose to the VOI compared to full-field techniques. When maintaining constant dose to the VOI, this change in iris diameter corresponds to a factor increase of approximately 1.6 in image contrast and a factor decrease in image noise of approximately 1.2. This results in a measured gain in contrast-to-noise ratio by a factor of approximately 2.0. The presented VOI technique offers improved image quality for image-guided radiotherapy while sparing the surrounding volume of unnecessary dose compared to full-field techniques.

TU-F-CAMPUS-T-03: A Novel Iris Quality Assurance Phantom for the CyberKnife Radiosurgery System

Purpose: A novel CCD camera and conical scintillator based phantom that is capable of measuring the targeting and field size accuracy of a robotic radiosurgery system has been developed. This work investigates its application in measuring the field sizes and beam divergence of the CyberKnife variable aperture collimator (Iris). Methods: The phantom was placed on the treatment couch and the robot position was adjusted to obtain an anterior -posterior beam perpendicular to the cone’s central axis. The FWHM of the 12 Iris apertures (5, 7.5, 10, 12.5, 15, 20, 25, 30, 35, 40, 50, and 60 mm) were measured from the beam flux map on the conical scintillator surface as seen by the CCD camera. For each measurement 30 MU were delivered to the phantom at a dose rate of 1000 MU/min. The measurements were repeated at 4 SAD distances between 75 and 85 cm. These readings were used to project the aperture size as if the flux map on the scintillator were located 80 cm from the source (SSD). These projected FWHM beam diameters were then compared to the commissioning data. Results: A series of 12 beam divergence equations were obtained from the 4 sets of data using linear trend lines on Excel scatter plots. These equations were then used to project the FWHM measurements at 80 cm SSD. The average aperture accuracy for beams from 5 through 40 mm was 0.08 mm. The accuracy for the 50 and 60 mm beams were 0.33 and 0.58 mm when compared to film commissioning data. Conclusion: The experimental results for 10 apertures agree with the stated Iris accuracy of ±0.2 mm at 80 cm SAD. The results for the 50 and 60 mm aperture were repeatable and can serve as a reliable trend indicator of any deviations away from the commissioning values. Brett Nelson is President/CTO of Logos Systems

Cytological changes during luminescence production in lanternshark (Etmopterus spinax Linnaeus, 1758) photophores

Studying an organism’s photogenic structures at the ultrastructural level is a key step in the understanding of its light-emission process. Recently, the photophore ultrastructure of the deep-sea lanternshark Etmopterus spinax Linnaeus, 1758 was described. The photocytes appeared to be divided into three areas including an apical granular area, which contains inclusions and was hypothesized to be the light-producing reaction site. In this study, we investigated the morphological changes occurring within the granular area during the bioluminescent emissions induced by two hormones: prolactin and melatonin. Prolactin provoked the formation of new structures in the granular area, the “grey particles”, whose number was proportional to the amount of light produced by the reaction. An increase in the number of granular inclusions was also detected at the end of the prolactin-induced light emission. Conversely, melatonin induced a decrease in the number of granular inclusions and an increase in their diameter. An effect of hormones was also observed on the iris-like structure where they triggered pigment retraction and hence an increase in the iris aperture diameter. This is consistent with previous findings and is shown for the first time at the cellular level. The possible role of grey particles in E. spinax light-emission mechanism is discussed, while granular inclusion is considered to be E. spinax’s intracellular luminescence site. Regarding typical shark long-lasting glows, a new term (“glowon”) is proposed to characterize this novel membrane-free microsource.

SU‐E‐T‐453: A Novel Daily QA System for Robotic Image Guided Radiosurgery with Variable Aperture Collimator

Purpose:A novel end‐to‐end system using a CCD camera and a scintillator based phantom that is capable of measuring the beam‐by‐beam delivery accuracy of Robotic Radiosurgery has been developed and reported in our previous work. This work investigates its application to end‐to‐end type daily QA for Robotic Radiosurgery (Cyberknife) with Variable Aperture Collimator (Iris).Methods:The phantom was first scanned with a CT scanner at 0.625 slice thickness and exported to the Cyberknife Muliplan (v4.6) treatment planning system. An isocentric treatment plan was created consisting of ten beams of 25 Monitor Units each using Iris apertures of 7.5, 10, 15, 20, and 25 mm. The plan was delivered six times in two days on the Cyberknife G4 system with fiducial tracking on the four metal fiducials embedded in phantom with re‐positioning between the measurements. The beam vectors (X, Y, Z) are measured and compared with the plan from the machine delivery file (XML file). The Iris apertures (FWHM) were measured from the beam flux map and compared with the commissioning data.Results:The average beam positioning accuracies of the six deliveries are 0.71 ± 0.40 mm, 0.72 ± 0.44 mm, 0.74 ± 0.42 mm, 0.70 ± 0.40 mm, 0.79 ± 0.44 mm and 0.69 ± 0.41 mm respectively. Radiation beam width (FWHM) variations are within ±0.05 mm, and they agree with the commissioning data within 0.22 mm. The delivery time for the plan is about 7 minutes and the results are given instantly.Conclusion:The experimental results agree with stated sub‐millimeter delivery accuracy of Cyberknife system. Beam FWHM variations comply with the 0.2 mm accuracy of the Iris collimator at SAD. The XRV‐100 system has proven to be a powerful tool in performing end‐to‐end type tests for Robotic Image Guided Radiosurgery Daily QA.

TH‐A‐18C‐11: An Investigation of KV CBCT Image Quality and Dose Reduction for Volume‐Of‐Interest Imaging Using Dynamic Collimation

Purpose:The focus of this work was to investigate the improvements in image quality and dose reduction for volume‐of‐interest (VOI) kV‐CBCT using dynamic collimation.Methods:A prototype iris aperture was used to track a VOI during a CBCT acquisition. The current aperture design is capable of one‐dimensional translation as a function of gantry angle and dynamic adjustment of the iris radius. The aperture occupies the location of the bow‐tie filter on a Varian OBI system. CBCT and planar image quality was investigated as a function of aperture radius, while maintaining the same dose to the VOI, for a 20 cm diameter cylindrical water phantom with a 9 mm diameter bone insert centered on isocenter. Corresponding scatter‐to‐primary ratios (SPR) were determined at the detector plane with Monte Carlo simulation using EGSnrc. Dose distributions for various anatomical sites were modeled using a dynamic BEAMnrc library and DOSXYZnrc. The resulting VOI dose distributions were compared to full‐field distributions.Results:SPR was reduced by a factor of 8.4 when decreasing iris diameter from 21.2 cm to 2.4 cm (at isocenter). Similarly, this change in iris diameter corresponds to a factor increase of approximately 1.4 and 1.5 in image contrast for CBCT and planar images, respectively, and similarly a factor decrease in image noise of approximately 1.7 and 1.5. This results in a measured gain in contrast‐to‐noise ratio of a factor of approximately 2.3 for both CBCT and planar images. Depending upon the anatomical site, dose was reduced to 10%–70% of the full field value along the central axis plane and down to 2% along the axial planes, while maintaining the same dose to the VOI compared to full‐field techniques.Conclusion:The presented VOI technique offers improved image quality for image‐guided radiotherapy while sparing the surrounding volume of unnecessary dose compared to full‐field techniques.

Tunable liquid iris actuated using electrowetting effect

A configuration for a tunable liquid iris, which consists simply of two immiscible liquids and two flat indium tin oxide (ITO) glass substrates, is proposed. The two immiscible liquids are transparent salt solution and opaque oil, respectively. The top ITO electrode was precoated with a 2-μm-thick polydimethylsiloxane film as the dielectric layer, while the surface of the bottom electrode was specially treated using ultraviolet irradiation to define specific hydrophilic regions. The iris aperture’s diameter could easily be regulated by varying the direct current bias voltages between the two electrodes. Results show that the aperture diameter can be continuously varied from 1.5 mm at the voltage-off state to 3.5 mm at a bias of 350 V. This liquid iris takes the advantages of low fabrication cost, fast response time, low-power consumption, and easy reversibility without the need of any mechanical movable parts.

Variable aperture controlled by microelectrofluidic iris

This Letter presents an adaptive liquid iris based on microelectrofluidic technology with experimental results. In the microelectrofluidic iris (MEFI), the electrostatic force generated by electrowetting in a surface channel unbalances the Laplace pressure acting on two fluidic interfaces between air and a light-absorbing liquid in two connected surface channels in a chamber. Then, the changed net pressure makes the iris aperture of the liquid diaphragm adjustable. The present MEFI was designed to have a tunable range from 4.2 to 0.85 mm in diameter and a tuning ratio of 80%. The MEFI was fabricated with a transparent electrode patterned on three glass plates and two channel spacers. Concerning the optical and interfacial properties of the MEFI for its operation, an aqueous near-infrared dye used in optical coherence tomography (OCT) was forced into a ring shape as the driving liquid in the hydrophobic chamber. By switching the segmented concentric control electrodes in steps, digital operation of the MEFI was successfully observed with clear aperture stops. The measured turnaround speed was 80 mm/s, which is significantly higher than that for other comparable adaptive liquid irises. Due to a scalable aperture range with fast response, the concept of MEFI is expected to be widely applied in various optical systems that require high-quality imaging, as well as in real-time diagnostic OCT.