The National Spherical Torus Experiment Upgrade (NSTX-U) will advance the physics basis required for achieving steady-state, high-beta, and high-confinement conditions in a tokamak by accessing high toroidal fields (1 T) and plasma currents (1.0–2.0 MA) in a low aspect ratio geometry (A = 1.6–1.8) with flexible auxiliary heating systems (12 MW NBI, 6 MW HHFW). This paper describes the progress in the development of L- and H-mode discharge scenarios and the commissioning of operational tools in the first ten weeks of operation that enable the scientific mission of NSTX-U. Vacuum field calculations completed prior to operations supported the rapid development and optimization of inductive breakdown at different values of ohmic solenoid current. The toroidal magnetic field (BT0 = 0.65 T) exceeded the maximum values achieved on NSTX and novel long-pulse L-mode discharges with regular sawtooth activity exceeded the longest pulses produced on NSTX (tpulse > 1.8 s). The increased flux of the central solenoid facilitated the development of stationary L-mode discharges over a range of density and plasma current (Ip). H-mode discharges achieved similar levels of stored energy, confinement (H98y,2 > 1) and stability (βN/βN-nowall > 1) compared to NSTX discharges for Ip ⩽ 1 MA. High-performance H-mode scenarios require an L–H transition early in the Ip ramp-up phase in order to obtain low internal inductance (li) throughout the discharge, which is conducive to maintaining vertical stability at high elongation (κ > 2.2) and achieving long periods of MHD quiescent operations. The rapid progress in developing L- and H-mode scenarios in support of the scientific program was enabled by advances in real-time plasma control, efficient error field identification and correction, effective conditioning of the graphite wall and excellent diagnostic availability.