After 1990, when the economic system changed in Romania, the mining industry was the most controversial field from a productive-economic point of view and subject to reforms and transformations for efficiency. Currently (2022), there are nine main mining perimeters in which the production of useful, energetic, and nonenergetic mineral substances is operational, and in others it has decreased or stopped. Still active mining areas need economic and ecological assessments to identify similarities and proximity symmetries for informed exploitation decisions and feasible complex resource utilization. The main objective of our study is to define a framework for the theoretical and practical contribution to the substantiation of decisions and expressions of interest regarding future investments in mining projects for useful and energetic and non-energetic mineral substances in Romania. Investments in the mining industry are expensive, with major risks and subunit success rates for specific geotechnological conditions. The purpose of the research is to provide the methodology for using some variables of similarities from proximity mining deposits in the stage of exploitation or post-exploitation affected by anthropogenic activity in the national geological territory through a case study of Romania. With the help of statistical scales, the research results highlight that in the exploitation and post-mining perimeters in Romania, the states of “affect” and “post-affect” anthropic, respectively, of eco-economic damage are in a maximum proportion of approximately 36% in relation to the ideal situations of no affect. For a mining investment project, knowing similar or symmetrical exploitation and post-exploitation properties and situations, and from the geological deposits in the vicinity, premises are created for optimized strategic and tactical decisions, based on reality and, above all, for the provision of expressions of interest for new investments that have a programmed, expected success rate.