In this work, we study the influence of Doppler broadening on cross-Kerr nonlinearity in a four-level inverted-Y atomic system under electromagnetically induced transparency (EIT) condition. The first- and third-susceptibilities in the presence of Doppler effect are derived as a function of probe, signal and coupling beams and temperature of medium. Under EIT condition, cross-Kerr nonlinearity is enhanced several orders of magnitude compared to that without EIT. The Doppler effect leads to a reduction in the transparent efficiency and thus reduces the amplitude of cross-Kerr nonlinear coefficient. For hot atomic gaseous medium, such consideration of the Doppler effect may be useful for experimental observations and apply to photonic devices operating at different temperature conditions.