Inverse Sign Research Articles

Response to: Distinguish inverse Gottron's papules and inverse Gottron's sign in anti-MDA5 dermatomyositis.

Response to: Distinguish inverse Gottron's papules and inverse Gottron's sign in anti-MDA5 dermatomyositis.

Inverse Gottron's Sign in a Patient with Dermatomyositis.

Inverse Gottron's Sign in a Patient with Dermatomyositis.

A high‐dimensional inverse norm sign test for two‐sample location problems

AbstractIn this article, we focus on the two‐sample location testing problem for high‐dimensional data, where the data dimension is potentially much larger than the sample sizes. First, we construct a general class of weighted spatial sign tests for the two‐sample location problem, which can include some existing high‐dimensional nonparametric tests. Then, in this article, we find a locally most powerful test by choosing the inverse norm weight function, named the two‐sample inverse norm sign test (tINST). The proposed test can be viewed as an extension of the inverse norm sign test devised for the one‐sample problem. We establish the asymptotic properties of the proposed test, which indicate that it is consistent and has greater power than competing tests that belong to the proposed class of weighted spatial sign tests for two‐sample location problems. Finally, a large number of numerical investigations and a practical biomedical example demonstrate the power and robustness advantages of the proposed test.

Electronic and elastic properties of BN, AlN and GaN

We have carried out first-principles total energy calculations to investigate electronic and elastic properties of both zinc-blende and wurtzite BN, AlN, and GaN. We have calculated lattice parameters, elastic constants, deformation potential constants, phonon frequencies at r point, Born effective charges, and piezoelectric constants. Lattice parameters are fully relaxed by using the first-principles molecular dynamics method with variable cell shape. The internal strain in a strained crystal is also relaxed by the first-principles molecular dynamics method. The internal strain influences the elastic constants, the deformation potential constants, and the piezoelectric constants effectively. We have calculated the wurtzite deformation potential constants D1 – D5 considering the internal strain correction. The piezoelectric constants of wurtzite and also zinc-blende crystals have been calculated using the Berry phase approach and we have found from first principles that those of BN have an inverse sign in contrast to AlN and GaN. Discussions will be given in comparison with results obtained herein with the previous ones. © 1998 American Institute of Physics. [S0021-8979(98)07921-3]

Valley-resolved interband excitation and emission in gapped graphene

We theoretically investigate the electronic dynamics in gapped graphene driven by a bicircular field. The results indicate that the residual population on the conduction band is obviously asymmetric in the K and ${\mathrm{K}}^{\ensuremath{'}}$ valleys. Through analyzing the electron trajectory, we find that the interband transitions are determined by the compensation of two phases: the dynamic phase and the full dipole phase (including the transition dipole phase and the Berry phase). When the rates of change of the dynamic phase and the full dipole phase nearby the ionization time have the inverse signs, the unidirectional interband transition from the valence band (VB) to the conduction band (CB) results in the constructive interference of the population. In contrast, when they have the same signs, the bidirectional transition (CB$\ensuremath{\rightarrow}$VB and VB$\ensuremath{\rightarrow}$CB) results in the destructive interference. The constructive interference and the destructive interference lead to the asymmetric distribution of the CB population. Moreover, we also investigate the harmonic emission and find that only the $3n+2$ harmonics are generated in the cutoff region. This phenomenon can be attributed to the asymmetric distribution of the CB population and the trefoil vector potential of the electric field. Due to the dependence on population distribution, the harmonics can be a promising optical way to detect the valley excitation of the gapped graphene.

Electronic and elastic properties of BN, AlN and GaN

We have carried out first-principles total energy calculations to investigate electronic and elastic properties of both zinc-blende and wurtzite BN, AlN, and GaN. We have calculated lattice parameters, elastic constants, deformation potential constants, phonon frequencies at r point, Born effective charges, and piezoelectric constants. Lattice parameters are fully relaxed by using the first-principles molecular dynamics method with variable cell shape. The internal strain in a strained crystal is also relaxed by the first-principles molecular dynamics method. The internal strain influences the elastic constants, the deformation potential constants, and the piezoelectric constants effectively. We have calculated the wurtzite deformation potential constants D1 – D5 considering the internal strain correction. The piezoelectric constants of wurtzite and also zinc-blende crystals have been calculated using the Berry phase approach and we have found from first principles that those of BN have an inverse sign in contrast to AlN and GaN. Discussions will be given in comparison with results obtained herein with the previous ones. © 1998 American Institute of Physics. [S0021-8979(98)07921-3]

A cryptocurrency empirical study focused on evaluating their distribution functions

This paper thoroughly examines the statistical properties of cryptocurrency returns, particularly focusing on studying which is the best statistical distribution for fitting this type of data. The preliminary statistical study reveals (i) high volatility, (ii) an inverse leverage effect, (iii) skewed distributions and (iv) high kurtosis. To capture the nonnormal characteristics observed in cryptocurrency data, we verified the goodness of fit of a large set of distributions, both symmetric and skewed distributions such as skewed Student-t, skewed generalized t, skewed generalized error and the inverse hyperbolic sign distributions. The results show that the skewed distributions outperform normal and Student-t distributions in fitting cryptocurrency data, although there is no one skewed distribution that systematically better fits the data. In addition, we compare these distributions in terms of their ability to forecast the market risk of cryptocurrencies. In line with the results obtained in the statistical analysis, we find that the skewed distributions provide better risk estimates than the normal and Student-t distributions, both in short and long positions, with SGED being the distribution that provides better results.

Macroeconomic Fundamentals and Budget Deficit Nexus: Evidence from a Developing Economy

The increasing budget deficit of the Nigeria’s government in the past few decades with its attendance impact on the economy is worrisome. This study examines the impacts of macroeconomic fundamentals on Nigeria’s fiscal deficit. An error correction model was specified and estimated. In terms of sign and size, the result showed that, there is an inverse relationship between budget deficit and the external reserve. This implies that an increase in the external reserve, leads to a decrease in budget deficits. A unit increase in external reserves resulted in 12.4 percent fall in budget deficit. In contrast, however, national income and interest rate showed a positive relationship with budget deficit. Increase in income expands the potential and propensity to spend. Lenders are equally more disposed to lend to the government because of the presupposed economic prosperity. The lagged value of the error correction term has the expected inverse sign of -0.42, and highly significant. The negative value of the error correction model further supports the co-integration relationship among the variables. Thus, macroeconomic variables influence budget deficits. Economic policies which minimizes macroeconomic fluctuations is paramount in curbing the negative impacts of increasing government deficit in the economy. Received: 2 May 2021 / Accepted: 15 June 2021 / Published: 8 July 2021

Numerical approach for a continuum theory with higher stress gradients

AbstractWe use an extended balance of linear momentum derived from stress field analysis of higher order terms in power series expansion. Thus, the balance equation accounts for higher gradients of stress in the contiguity of continuum points. Interestingly, it does not coincide with the balance of linear momentum from strain gradient elasticity. As shown in [1], it exhibits an inverse sign for the extended term compared to strain gradient elasticity. We are interested in the mechanical interpretation of this inversed sign since it seems to inverse the stiffening effect of strain gradient elasticity. Therefore, we set up the weak form of our extended balance equation by means of Galerkin's approach. Then, we use the Finite Element Method to approximate the weak form with help of different shape functions. In this context we also use Isogeometric Analysis since it is very promising for a numerical model with higher gradients.

Enhanced thermoelectric performance in MnTe due to doping and in-situ nanocompositing effects by Ag2S addition

Extremely low lattice thermal conductivity is always the pursuit of thermoelectric materials research. In this work, we reported an exceptional effect of Ag2S addition in MnTe, an emerging promising mid-temperature thermoelectric material, to enable the realization of minimum lattice thermal conductivity, namely ∼0.4 Wm−1K−1. Such a low lattice thermal conductivity is guaranteed by the incorporation of in-situ formed Ag rich phase (Ag2Te) with ultralow lattice thermal conductivity and further scattering of phonons from the partial doping effects induced point defects and boundaries between various phases. Apart from the dramatically decreased lattice thermal conductivity, the partial doping of Ag and S simultaneously enhance the electrical conductivity, further contributing to enhanced thermoelectric performance. Meanwhile, an inverse sign of Seebeck and Hall coefficient was observed and rationalized by the influence of highly electron-conductive Ag2Te phase. Thanks to the synergetic modulation of electrical and thermal transport properties by in-situ formed composite, a high ZT value of 1.1 was achieved in MnTe based thermoelectric materials, which also demonstrates the importance of compositing approaches to design state-of-the-art thermoelectric materials.

Inverse atoll sign as preoperative indicator of posterior capsular defects in posterior lenticonus

Two children with unilateral posterior lenticonus and cataract underwent lens matter aspiration with implantation of a 3-piece intraocular lens. Posterior capsular defect (PCD) was suspected on preoperative slitlamp examination, which was supported by swept-source optical coherence tomography and subsequently confirmed intraoperatively. Based on the findings observed in these 2 cases, an inverse atoll sign for preoperative detection of a PCD is described.

Index “Corona”: Symbolic Employment of COVID-19 in the Public Discourse in Serbia

In this paper we analyze the different ways in which COVID-19 is used as a carrier of cultural communication, whereupon it appears as a signifier of other socio-cultural phenomena and as a conveyer of messages of such communication. Accordingly, this paper will not observe health plan of COVID-19, nor the accompanying sociological phenomena of the epidemic in the strict sense of the word, but will focus instead on the cultural dimension of the infection. As a cultural phenomenon, the process of the planetary spread of COVID-19 infection – and hence the virus itself – can be viewed as an ambiguous symbol through which the collective experience of reality is constructed and communicated, perceived and interpreted. By relying on the decades-long tradition of Serbian ethnology and anthropology in the modified application of structural-semantic analysis, we define the use of COVID-19 as a symbolic means of cultural communication, here seen as indexical. This means that the said communication is organized on the principle that “A indicates B”, where the signifying A refers to the metaphorical and metonymic use of the disease, and B refers to various social phenomena related to it. As a metonymy, the considered phenomenon can be seen in the light of the classical binary division of purity and danger, whereupon the virus, in the cultural sense, divides the whole social reality into pure (still unpolluted) and impure aspects, one corresponding to the “normal” condition of things, and the other indicating a sense of explicit danger – not only from infection, but from the collapse of the social system and the disintegration of public health and community as well. As a metaphor, we observe the virus in relation to the official political instrumentalization of the discourse of warfare, which – depending on who employs it, and why – generates different notions on the “invisible enemy”, war victims (deceased as a consequence of infection) and “(super) heroes” (primarily, health workers, but also state officials and other public figures). COVID-19 is, however, peculiar because it can also play the role of an inverse sign, by which common cultural concepts and representations are perverted, destabilizing the shared sense of “real” and “normal”.

Evidence that cannabinoid CB1 receptors regulate intraocular pressure via two opposing mechanisms

The cannabinoid signaling system regulates intraocular pressure (IOP) in the mouse via a complex system that includes three receptors: CB1, GPR18 and GPR119. In each case, activating the receptor lowers IOP, but CB1 receptors are found both at sites of aqueous humor inflow and outflow. As such, knockout mice for any of these receptors would be expected to have higher-than average, or at least unchanged, intraocular pressure. The current study investigates the unexpected observation that CB1 knockout mice have lower pressure than wild type counterparts by testing various regulators of cannabinoid signaling in murine models of IOP. We now report that a CB1 antagonist has differential effects on IOP: SR141716 raises IOP in standard light cycle (SLC) but lowers IOP in reverse light cycle (RLC). This is mimicked by ABD1085, a negative allosteric modulator of CB1. CB1 inhibitors lower IOP in both normotensive and hypertensive mouse eyes. The pressure-lowering effect is absent in CB1 knockout mice. IOP rebounds after the end of treatment but shows no sign of desensitization with daily treatment for a week. Unlike the positive cannabinoid effect, antagonist effects are not sex-dependent. We propose that there are two mechanisms of action for CB1, one that lowers IOP upon activation and a second with inverse sign that lowers IOP when CB1 is antagonized. The relatively lower pressure in CB1 knockout mouse eyes suggests that this second negative regulation of IOP is dominant.

An Inverse Norm Sign Test of Location Parameter for High-Dimensional Data

We consider the one sample location testing problem for high-dimensional data, where the data dimension is potentially much larger than the sample size. We devise a novel inverse norm sign test (INST) that is consistent and has much improved power than many existing popular tests. We further construct a general class of weighted spatial sign tests which includes these existing tests, and show that INST is the optimal member within this class, in that it is consistent and is uniformly more powerful than all other members. We establish the asymptotic null distribution and local power property of the class of tests rigorously. Extensive numerical experiments demonstrate the superiority of INST in terms of both efficiency and robustness.

Inverse Gottron's sign in anti-MDA5 antibody-associated dermatomyositis.

Inverse Gottron's sign in anti-MDA5 antibody-associated dermatomyositis.

Inverse Gottron papules in juvenile dermatomyositis: an under recognized clinical entity.

The objective of this study was to report four children having juvenile dermatomyositis (JDM) with inverse Gottron sign along with a brief review of literature of similarly published cases. This is a retrospective review of case records of all children diagnosed with JDM at a single tertiary care centre in North India. Children who were found to have Gottron papules over palmar surface were identified. A total of 127 children were diagnosed with JDM in the last 24years (1994-2017). Out of these 127 patients, 4 were found to have Gottron papules over palmar surface. The median age at presentation of these four patients was 9years (range 8-10). The distribution for inverse Gottron papules was over the palmar aspect of proximal and distal interphalangeal joints, palmar creases and lateral aspects of proximal and distal interphalangeal joints. One child also had features of systemic scleroderma overlap and one patient had patchy lipoatrophy. ANA were positive in two patients. High-resolution computed tomography (HRCT) chest was carried out in all four patients and three of them were found to have changes consistent with interstitial lung disease. Prednisolone was used for all patients, methotrexate in three, azathioprine in two and cyclophosphamide in one patient. Inverse Gottron papule is a hitherto uncommonly recognized cutaneous manifestation of JDM. The clinical implications of this sign are yet not clear in children with JDM. Children with JDM with palmar Gottron papules may be screened for ILD as this may change their management and prognosis.

Allographs, graphic variants and iconic formulae in the kohau rongorongo script of Rapa Nui (Easter Island)

In a writing system with a large number of signs, in particular in the case of a pictorial script, some similarity of two graphic designs is an insufficient basis for considering them to have the same reading value. This paper seeks to apply concepts developed in the graphic analysis of other pictorial writing systems to the still undeciphered script of Rapa Nui (Easter Island). The following technical terms are adapted and defined from both theoretical and practical points of view: sign, reading value, graphic design, allograph, graphic variant, seeming graphic variant, iconic formula, and complete, incomplete and false substitution. A modified version of the substitution method (method of inverse sign substitution) is proposed for verifying equivalences and differences between readings values corresponding to the graphic designs analysed in this paper. This method is based on the assumption that two graphic designs that possess the same reading value are in free distribution, so the probability of sign substitution between them should be close to the probability obtained by multiplying the probabilities of their occurrences in texts. Application of these technical concepts to the parallel texts discovered by Boris Kudrjavtzev shows that many graphically similar signs with different reading values have not been previously recognised. This conservative graphic analysis also has permitted the identification of allographs in the strict sense of the word, i.e., signs that look different but possess the same reading value. However, technically speaking, “allograph” in the strict sense of the word is an antonym for “graphic variant”. It is suggested that the method of iconic formulae provides a useful foundation for future iconographic analysis of the highly pictorial signs of the Kohau Rongorongo script.

Electrochemical actuation behaviors of bulk nanoporous palladium in acid and alkaline solutions

Metallic actuators have attracted a great deal of attention owing to their potential advantages over piezoelectric ceramics and conducting polymers. Here, we report different electrochemical actuation behaviors of bulk nanoporous palladium (np-Pd) fabricated by dealloying in acid (0.5M H2SO4) and alkaline (1.0M KOH) solutions. In the 1.0M KOH solution, the reversible expansion/contraction of np-Pd well responds to the adsorption/desorption of involved species (H and OH). In the 0.5M H2SO4 solution, only continuous contraction can be observed in the potential region involving the H-adsorption/desorption, but the reversible strain appears in the potential region related to the OH-adsorption/desorption. Moreover, the surface stress-charge coefficient (ξ) exhibits inverse signs associated with the H-adsorption (absorption)/desorption and OH-adsorption/desorption in the alkaline solution. More importantly, the reversible strain amplitude of np-Pd can be regulated by changing the potential scan rate or by being stimulated in different electrolytes.

Negative Coulomb Drag in Double Bilayer Graphene.

We report on an experimental measurement of Coulomb drag in a double quantum well structure consisting of bilayer-bilayer graphene, separated by few layer hexagonal boron nitride. At low temperatures and intermediate densities, a novel negative drag response with an inverse sign is observed, distinct from the momentum and energy drag mechanisms previously reported in double monolayer graphene. By varying the device aspect ratio, the negative drag component is suppressed and a response consistent with pure momentum drag is recovered. In the momentum drag dominated regime, excellent quantitative agreement with the density and temperature dependence predicted for double bilayer graphene is found.

入浴姿勢の推定アルゴリズムの構築

Bathing in a bathtub filled with water is a custom common in Japan. Since comfort is important in bathing, comfortable bathtub design is desired. In the previous study, the algorithm to estimate reaction forces from bathtub was constructed. However, in order to evaluate the comfort of the bathtub in simulation completely, it was necessary to know bathing posture without experiments. The objective of this study was to construct the algorithm to estimate bathing posture. This algorithm determines the bathing posture that minimizes weighted summation of i) sum of joint torques of hip, knee, and ankle, ii) passive elastic joint torques of toes, and iii) inverse sign of the buoyancy. In the calculation, gravity, buoyancy, passive elastic joint torque and estimated reaction forces by algorithm constructed in previous study were considered. In order to examine this algorithm, a bathing experiment to obtain the data of bathing posture for 10 subjects and 4 bathtub shapes for each subject was conducted. It was found that the estimated bathing posture were consistent well with the measured bathing posture within 5.2% error.