Intravenous Laser Irradiation Research Articles

Lipid Metabolism Disorders and its Correction in Patients with Critical Lower Limb Ischemia During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation Using Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period

Lipid Metabolism Disorders and its Correction in Patients with Critical Lower Limb Ischemia During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation Using Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period

Cytokine Activity Indicators Dynamics after Non-Drug Rehabilitation including Intravenous Laser Blood Irradiation in Patients with a Lower Limb Post-Thrombophlebitic Syndrome: a Randomized Study

INTRODUCTION. Previous studies have established the association of venous thrombosis risk factors with inflammation, and the important role of inflammatory mediators as prognostic markers of recanalization of veins after deep vein thrombosis and the progression of postthrombophlebitic syndrome (PTPS). Pro-inflammatory cytokines, as key inflammatory mediators, are part of several cascades of pathophysiology in venous thrombosis, as well as predictors of the occurrence and prolongation of acute thrombosis and its resolution. To date, new oral anticoagulants are used, but their use in medical practice does not lead to a decrease in the number of patients with PTPS.
 AIM. To study the dynamics of proinflammatory cytokine levels under the influence of a complex non-drug method including intravenous laser irradiation of blood (ILBI) in patients with PTPS.
 MATERIALS AND METHODS. We conducted a randomized study that included 60 patients aged 58.3 ± 12.56 years with lower extremity PTPS (CVI C4–C5 according to CEAP clinical classification) divided into 2 groups. The subjects of the 1st group (main, n = 30) received: ILBI, pulsed magnetotherapy and dry-air carbon dioxide baths. After a complex of physiotherapy procedures, patients underwent therapeutic gymnastics in the gym according to the Brunner U. method. Subjects of the main group received the above rehabilitation complex against the background of phlebotonics (combination of diosmin and hesperidin) and the use of knitwear of 2–3 compression classes. Patients of the 2nd group (control group, n = 30) received standard elastic compression (2–3 compression class), similar drug therapy with phlebotonics and therapeutic gymnastics in the gym according to the method of Brunner U.
 RESULTS. After the course of rehabilitation, the patients of the main group showed positive dynamics of the main clinical symptoms of the disease, a decrease in malleolar volume, correction of microcirculatory disorders and activity of proinflammatory cytokines, accompanied by an improvement in transcapillary metabolism and tissue hypoxia. In patients of the control group, only a decrease in the number of leukocytes and fibrinogen in peripheral blood was recorded, while no changes in the expression of proinflammatory cytokines were observed. In this group of subjects, there was a positive trend in the regression of edema in terms of malleolar volume.
 CONCLUSION. As a result of the application of the proposed rehabilitation complex, which includes, along with the traditionally used physical factors (pulsed magnetotherapy, dry-air carbon dioxide baths and therapeutic gymnastics) ILBI procedures, not only decongestant, hypocoagulating effects, positive dynamics of the main clinical symptoms of the disease were noted, but also correction of microcirculatory disorders and the level of pro-inflammatory cytokines was achieved, accompanied by an improvement in transcapillary metabolism and trophic tissues.

Laser Therapy in Comprehensive Treatment of Patients with Lymphedema of Lower Limbs

INTRODUCTION: Methods of physiotherapy using intravenous laser irradiation of blood (ILIB) that affects various pathogenetic factors of lymphedema, permits to achieve the required therapeutic effect and shows its promising perspectives.
 AIM: Evaluation of the effectiveness of ILIB to reduce the lymphedema volume in the lower limbs.
 MATERIALS AND METHODS: In 2020–2022, a comprehensive conservative treatment including compression therapy, pharmacotherapy and ILIB, was conducted in 60 patients of the mean age 45.3 ± 1.6 years with I–III stage lymphedema. Group 1 included patients with primary (n = 8) and group 2 (n = 52) with secondary lymphedema of the lower limbs. Laser radiation at 632 nm wavelength was used with standardized parameters: power 3 to 15 mW, pulse rate 80 to 2,000 Hz, exposure time 5 to 15 min, with a course (up to 10 sessions), daily, or interval (every 2nd day) load. Lymph outflow, microcirculation, soft tissues of the affected limb were evaluated using electrocoagulography, ultrasound examination of inguinal lymph nodes and soft tissues, triplex scanning, thermal imaging and McClure-Aldrich test.
 RESULTS: At the end of the treatment course, a reduction of the limb perimeter at the level of the middle third of the lower leg by 14.8 ± 0.7% was noted (from 48.7 ± 5.3 cm to 41.4 ± 0.9 cm). After 4 sessions and a treatment course, electrocoagulography revealed hypocoagulation with the formation of a loose clot with early retraction. Spearman test showed a direct relationship between changes in the fibrinolytic activity of blood and the perimeter of the lower leg in patients of group 2 with I–II stage of the disease (p 0.005). Thermography of the lower limbs showed increased IR radiation with a statistically significant increase (p 0.001) in the area of hyperthermia in the distal parts of the lower legs and the inner surface of the thighs. The results of McClure-Aldrich test showed a statistically significant slowdown of a skin papule resolution in the distal part of the lower legs from 27.13 ± 2.77 min to 35.72 ± 3.11 min (р 0.05) after ILIB in I stage of the disease.
 CONCLUSION: ILIB affects the internal factors of lymph outflow and contributes to its optimization in the comprehensive treatment of patients in the initial stage of secondary lymphedema of the lower limbs.

Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy

Biological membranes often play important functional roles in biomimetic drug delivery systems. We discover that the circulation time and targeting capability of biological membrane coated nanovehicles can be significantly improved by reducing cholesterol level in the coating membrane. A proof-of-concept system using cholesterol-reduced and PD-1-overexpressed T cell membrane to deliver a photothermal agent and a STING agonist is thus fabricated. Comparing with normal membrane, this engineered membrane increases tumor accumulation by ~2-fold. In a melanoma model in male mice, tumors are eliminated with no recurrence in >80% mice after intravenous injection and laser irradiation; while in a colon cancer model in male mice, ~40% mice are cured without laser irradiation. Data suggest that the engineered membranes escape immune surveillance to avoid blood clearance while keeping functional surface molecules exposed. In summary, we develop a simple, effective, safe and widely-applicable biological membrane modification strategy. This “subtractive” strategy displays some advantages and is worth further development.

Immunocorrection in Patients with Critical Ischemia of the Lower Extremities During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation with the Use of Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period

Immunocorrection in Patients with Critical Ischemia of the Lower Extremities During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation with the Use of Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period

The Adjuvant Therapy of Intravenous Laser Irradiation of Blood (ILIB) on Pain and Sleep Disturbance of Musculoskeletal Disorders.

(1) Background: Musculoskeletal pain is both intractable and irritating. Intravenous Laser Irradiation of Blood (ILIB) therapy has been used as pain control treatment for this condition. However, there remains a lack of clear evidence regarding ILIB on pain control. This study aimed to reveal the result of changes in patient pain intensity after receiving ILIB therapy. (2) Methods: We conducted a retrospective analysis of pain scores and sleep quality from 76 patients diagnosed with musculoskeletal disease who received three courses of ILIB therapy. Each course included ten sessions of ILIB treatment over ten consecutive days. During ILIB therapy, patients were inserted with a laser fiber optic needle which irradiated blood cells via a 632.8 nm Helium-Neon laser light over a period of 60 min. Pain scores were evaluated using the Visual Analogue Scale (VAS), whereas sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). These scores would be recorded both before and after each ILIB treatment course. (3) Results: The mean of all patients’ initial VAS score was 5.35. After completing three courses of ILIB treatment, the mean VAS score decreased to 2.2, which indicated a significant reduction in pain intensity. Additionally, patients experienced sleep quality improvement levels from PSQI 8.97 to 5.53 upon completion of three courses of ILIB treatment. (4) Conclusions: Intravenous Laser Irradiation of Blood (ILIB) resulted in a positive pain control effect on patients with musculoskeletal disease, especially for those with moderate to severe pain intensity (initial VAS score >4). Additionally, patients experienced better sleep quality as a result of their pain relief after receiving ILIB treatment.

Изменения иммунологических показателей при использовании комбинированного физиотерапевтического метода в комплексном лечении атопического дерматита у детей

The aim of this study was to evaluate changes in immunological parameters in children with atopic dermatitis when using hydrotherapy, non-selective chromotherapy, and intravenous laser irradiation of blood against the background of basic drug therapy. Materials and methods. The work was performed with the participation of 164 patients with moderate lichenoid and erythematous-squamous forms of atopic dermatitis aged 4 to 15 years with a frequency of exacerbations from 3 to 4 times a year with a tendency to increase their duration. The patients were divided into 5 groups: the first group received basic drug therapy (BDT), the second - hydrotherapy and BDT, the third - non-selective chromotherapy and BDT, the fourth - low-intensity laser irradiation of blood and BDT, the fifth - hydrotherapy, non-selective chromotherapy, low-intensity laser irradiation of blood and BDT. The content of total IgE, IL-4, IL-10, IL-13, IL-18 and TNF-α in the blood serum of patients was determined by enzyme immunoassay before treatment, as well as 1 and 3 months after its start. Results. Before the start of treatment, the values of all the studied indicators in comparison with healthy individuals were significantly increased (by 2.1-3.1 times). In patients of the first and second groups, the level of IgE and cytokines did not change significantly after 1 and 3 months from the start of treatment in comparison with the indicators before the start of treatment. In the third group, after 1 month from the start of treatment, the group experienced a significant (by 11-20%) decrease in IgE and cytokine levels, which persisted after 3 months of follow-up. In the fourth group, the decrease in the studied indicators after 1 month was even more significant and did not change significantly. The greatest decrease in indicators after 1 and 3 months was observed in the fifth group of patients (by 40-62%) who received basic drug therapy in combination with hydrotherapy, non-selective chromotherapy and intravenous laser irradiation of blood. Conclusion. In children with moderate atopic dermatitis, drug-based basic treatment combined with non-selective chromotherapy and intravenous laser irradiation of blood contributes to the effective correction of immunological reactivity for a long period of time.

Correction of structural and functional disorders of red blood cells by intravenous laser irradiation of peripheral blood in chronic endometritis

Correction of structural and functional disorders of red blood cells by intravenous laser irradiation of peripheral blood in chronic endometritis

Effectiveness of the curative complex consisting of photodynamic therapy, intravenous laser irradiation and local laser irradiation aimed at correcting hemostatic parameters at the initial stages of squamous cell skin cancer

Purpose. To assess the effectiveness of curative complex consisting of photodynamic therapy (PDT) + intravenous laser blood irradiation (ILBI) + local tumor irradiation (TR) at hemostatic parameters at the initial stages of squamous cell skin cancer (SCSC).Material and methods. The present work analyzes SCSC course in 185 patients who had outpatient and inpatient treatment in medical institutions of cities Engels and Saratov in 2015–2019. 129 (69.7%) males and 56 females (31.2%). Patients were divided into three groups. Group I – 74 (40%) patients who had combined treatment: surgery with wide tumor excision under intravenous anesthesia + PDT + ILBI + TR; Group II – 111 (60%) patients who had only surgical treatment. Group III was created for controlling and comparing the obtained laboratory parameters; it included 17 patients without established pathology.Results. It was found out that hemostatic disorders in SCSC are characterized by increased activity of AT III and vWF and by simultaneous decrease of tPA-PAI-1 complex as well as by increased activity of VIIIa factor and resistance of Va factor – indices which indicate dysfunction of endothelial vascular wall. Combination of PDT + ILBI + TR prior to surgical treatment in patients with squamous cell skin cancer at the initial stages of the disease allow to normalize homeostatic indices and reduce the number of complications.Conclusion. 1. Squamous cell skin cancer at the initial stages changes the hemostatic system. 2. Effects of SCSC mechanism may be characterized as follows: damage of the endothelium vascular wall which is confirmed by endothelin increase; it results in vasoconstriction and increased blood procoagulant activity and, ultimately, in changes of hemostatic parameters. 3. Combination of PDT + ILBI + TR applied before surgery in patients with squamous cell skin cancer at the initial stages of the disease normalizes homeostatic indices and reduces the number of complications.

Pilot Study of Application of Combined Transbronchial and Intravenous Ultraviolet C (UVC) and Laser Beam Application for the Treatment of Critical COVID-19 Infection

Objective and background: Light-based antimicrobials, mainly ultraviolet C (UVC) and laser light irradiation, have a potential to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of our study was to evaluate the effect of transbronchial and intravenous application of UVC and laser light irradiation on treatment of patients with severe COVID-19. Methods: The clinical outcome of six patients (age 42-69 years) with severe COVID-19 infection who were directly applied UVC (254 nm) transbronchially, and UVC plus green (630 nm) and red laser (535 nm) lights to the blood circulation in addition to standard pharmacotherapy (UVC group) were prospectively evaluated in comparison to six patients (age 50-69 years) treated only with pharmacotherapy (standard treatment group). Results: The patients in UVC group had shorter stay in intensive care unit (median length of stay 1 vs. 8.5 days; p=0.015), more negative PCR results after treatment (5/6 vs. 0/6 patients; p=0.003), higher discharge rate (5/6 vs. 3/6 patients), and lower mortality (1/6 vs. 3/6 patients), as compared to patients in standard treatment group. Serum D-dimer level, which reached up to 2500 ng/mL (six times of baseline value) seven days after treatment in standard treatment group, was much lower in UVC group (1000 ng/mL). Serum ferritin level was 1.5 to 1.9-fold higher and CRP level was up to 1.7-fold higher in standard treatment group during ten days after treatment as compared to UVC group. No adverse effects have been observed. Conclusions: Combined transbronchial and intravenous UVC and laser irradiation may improve outcome of severe COVID-19 cases.

Top-Down Redistribution of Brain Circulation from Thalamus to Cerebellum in Response to Intravenous Laser Irradiation of Blood in Case of Chronic Cerebellar Stroke: Pilot Observation from Brain Images

Top-Down Redistribution of Brain Circulation from Thalamus to Cerebellum in Response to Intravenous Laser Irradiation of Blood in Case of Chronic Cerebellar Stroke: Pilot Observation from Brain Images

Patients with purulent necrotic wounds treatment using by intravenous laser blood irradiation (405 nm)

Objective:to analyze the effectiveness of purulent-necrotic wounds management using intravenous laser irradiation of blood (405nm).Materials and methods. Object of study – patients with purulent-necrotic wounds. Clinical studies and analysis of the intravenous laser blood irradiation (405 nm) effect on the wound healing process and on the healing speed of purulent soft tissues wounds in patients with type 2 diabetes mellitus were carried out.Results.It was found that the use of intravenous laser blood irradiation (405 nm) is a highly effective method for the treatment of purulent soft tissues wounds, which allows to reduce the number of complications and shorten the time for complete epithelization of purulent wounds by 7–10 days compared with traditional treatment.

Местные и системные лечебные эффекты внутрисосудистой лазерной терапии у онкологических больных

Исследовано изменение гормонального гомеостаза, гемопоэза и патоморфоза опухоли у 152 больных раком молочной железы (Т2N0M0 и T3N1M0). Больным основной группы проводили от 5 до 10 сеансов внутривенного лазерного облучения крови (ВЛОК). После полного курса ВЛОК (10 сеансов) наблюдалась девитализация опухолевой паренхимы (уменьшение объемной доли жизнеспособных клеток на 30 %); восстановление гемопоэза и гормонального гомеостаза, что свидетельствует о местном и системном лечебном эффекте ВЛОК

The effect of a combination of laser therapy and handling of medical gymnastics on the indices of hemodynamics with dilated cardiomyopathy

The aim of the study: Combined use of kineso- and laser therapy to correct regional hemodynamic disorders in patients with dilated cardiomyopathy (DCMP). Material and methods: The study included 100 patients diagnosed with DCMP. The diagnosis "DCMP" was established for patients with dilatation of the heart cavity of non-coronatural origin, increased heart size (final diastolic size of the left ventricle - LV CDR > 6.0 cm). The determination of the CHF FC was made according to the Russian National Recommendations of the RSCS (2018) and OSSN on the diagnosis and treatment of CHF. All patients took differentiated medication-assisted therapy according to indications during 3 months. Patients were divided into 2 comparable groups by sex, age, disease course, severity of the condition, and specifics of medication therapy. Patients of the 1st group were treated with intravenous laser irradiation of blood (ILIB) and selection of unloading therapeutic gymnastics against the background of supporting differentiated medication therapy. Patients of the 2nd group (control) received only differentiated medication therapy. The main method of investigation was venous occlusal plethysmography to evaluate regional hemodynamics with the determination of blood flow (Qr) and regional vascular resistance (Rr) at rest, venous tone (Vt), reserve blood flow (QH) and regional vascular resistance (RH) on the background of a functional load test. РResults: The data obtained during the dynamic observation (in 1, 3, 6 and 12 months) in the main group showed a reliable increase in the volume velocity of the blood flow at rest (Qr) and the reserve blood flow (QH), a decrease in the regional vascular resistance at rest (Rr) and under functional load (RH), venous tone (Vt), respectively. In the control group there was no reliable positive dynamics, after 12 months of observation indicators of regional hemodynamics significantly deteriorated. Conclusion: In patients with DCMP, according to venous occlusal plethysmography, the use of relieving therapeutic gymnastics in combination with ILIB on the background of medication therapy has significantly improved the indices of regional hemodynamics. The developed method of non-drug therapy can be used by cardiologists, general practitioners, therapists, doctors of physical and rehabilitation medicine to optimize treatment of patients with DCMP.

Possibilities of the cellular immunity correction using intravenous laser irradiation of the blood and cytokinotherapy with roncoleukin in perioperative period while indirect revascularization done in patients with critical ischemia of the lower extremiti

Objective. To study up the possibilities of the cellular immunity correction using intravenous laser irradiation of the blood and cytokinotherapy with roncoleukin in perioperative period while indirect revascularization done in patients with critical ischemia of the lower extremities.
 Materials and methods. Prospective controlled clinic-laboratory investigation was performed in 162 patients, suffering critical ischemia of the lower extremities on background of distal arterial stenosis (occlusion) and to whom indirect revascularization operations were done. Etiology of the lower extremities critical ischemia were the obliterating atherosclerosis - in 108 (66.7%) patients and obliterating thrombangiitis - in 54 (33.3%) patients. In 56 patients a Degree III was diagnosed, and in 106 patients - IV Degree of chronic ischemia. In perioperative period in 34 patients a standard treatment was performed (Group I), in 32 patients - standard treatment and intravenous laser irradiation of the blood (Group II), in 32 patients - standard treatment and cytokinotherapy with roncolekin (Group III), in 33 patients - standard treatment, intravenous laser irradiation of the blood and cytokinotherapy (Group IV), in 31 patients in a revascularized osteotrepanation with intramedullary laser irradiation - standard treatment, intravenous laser irradiation of the blood and cytokinotherapy (Group V). Parameters of cellular immunity (CD3+, CD4+, CD8+lymphocytes; ratio CD4+/CD8+) and of phagocytosis were studied in dynamics. The cellular immunity indices were compared with identical indices in 48 practically healthy persons (a reference group).
 Results. While admittance to hospital in patients with critical ischemia of the lower extremities in a distal stenosis (occlusion) the abrupt change of cellular immunity was revealed towards the immune insufficiency. Inclusion of intravenous laser irradiation of the blood and of cytokinotherapy, separately or in combination, into the treatment measures complex of perioperative period in indirect revascularization have leaded towards trustworthy (p < 0.05) elimination of the cellular immunity indices. Correction of cellular immunity trustworthily depended on (p < 0.01-0.001) the treatment factor with moderate (r =0.5- 0.6) correlation. Best results were obtained while joint application of intravenous laser irradiation of the blood and cytokinotherapy in perioperative period in indirect revascularizaation, peculiarly while operation of revascularized osteotrepanation with intramedullary laser irradiation.
 Conclusion. Application of intravenous laser irradiation of the blood and cytokinotherapy together with standard treatment in perioperative period while doing indirect revascularization corrects the cellular immunity trustworthily in patients, suffering critical arterial ischemia of the lower extremities, and the dynamics of these indices may be used as an objective criterion of the efficacy estimation for the therapy conducted.

The use of physical factors in the postoperative period with destructive appendicitis in children: the current state of the problem

Acute appendicitis is the most common childhood surgical disease. With the use of laparoscopic appendectomy for destructive appendicitis in children, the number of postoperative complications significantly decreased. However, in recent years there has been no tendency towards their further decline. The use of non-drug exposure, which has both local and systemic anti-inflammatory effects, can lead to further improvement in the treatment results of the most severe forms of the disease. As a result of a literature review, it was found that there is very little information about the use of physical factors in the postoperative period with destructive appendicitis in children. The effectiveness of the physical factors of systemic exposure (intravenous laser irradiation of blood, the use of ozone) was noted, but currently there are no recommendations on the application of local exposure physiotherapy techniques. Thus, the study of the effectiveness of the use of physical factors in the postoperative period with destructive appendicitis in children at the present stage remains relevant.

Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.

The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant pathways. Recently, intranasal PBMT (i-PBMT) has become an attractive and potential method for the treatment of brain conditions. Herein, we provide a summary of different intranasal light delivery approaches including a nostril-based portable method and implanted deep-nasal methods for the effective systemic or direct irradiation of the brain. Nostril-based i-PBMT devices are available, using either lasers or light emitting diodes (LEDs), and can be applied either alone or in combination to transcranial devices (the latter applied directly to the scalp) to treat a wide range of brain conditions such as mild cognitive impairment, Alzheimer's disease, Parkinson's disease, cerebrovascular diseases, depression and anxiety as well as insomnia. Evidence shows that nostril-based i-PBMT improves blood rheology and cerebral blood flow, so that, without needing to puncture blood vessels, i-PBMT may have equivalent results to a peripheral intravenous laser irradiation procedure. Up to now, no studies were conducted to implant PBMT light sources deep within the nose in a clinical setting, but simulation studies suggest that deep-nasal PBMT via cribriform plate and sphenoid sinus might be an effective method to deliver light to the ventromedial part of the prefrontal and orbitofrontal cortex. Home-based i-PBMT, using inexpensive LED applicators, has potential as a novel approach for neurorehabilitation; comparative studies also testing sham, and transcranial PBMT are warranted.

THE USE OF INTRAVENOUS LASER BLOOD IRRADIATION IN THE TREATMENT OF PATIENTS WITH BEHCET’S SYNDROME

The results of a microbiological and PCR survey of patients with Behcet’s disease, as well as the results of intravenous laser irradiation of the blood (ILIB) are presented. According to the authors, the clinical picture of the disease was represented by the presence of single and multiple repeatedly recurring erosive and ulcerative defects in the area of the oral mucosa (cheek area and lateral surface of the tongue) and/or external genitalia. 4 patients noted soreness in the area of rashes, in 2 rashes were accompanied by a rise in temperature and the symptoms of malaise, weakness. Signs of catarrhal conjunctivitis and uveitis were present in 3 patients, while there was no reduction in visual acuity in the course of the disease. 3 patients had pain in large joints without visible changes on the radiograph and an increase in ESR up to 18-24 mm/h. As a result of the complex therapy with antibacterial, antiprotozoal, antiviral, antifungal therapy depending on the detected pathogen, as well as procedures of ILIB, the resorption of the infiltration zone was noted on the 10-11th day of treatment. Ulcerative elements began to epithelize. Erythema, feelings of burning and pain were absent.

The prevention of cardio-vascular diseases in workers of enterprises of mining industry

The leading increasing of cardiovascular pathology in miner workers dictates necessity of development of effective methods of prevention. The article presents the results of application of intravenous blood laser irradiation in miner workers with cardiovascular pathology. The evaluation of condition of cardio-vascular system was carried out to detect mine workers with high cardio-vascular risk. To this group of mine workers course of preventive procedures was prescribed. The course included common medicinal treatment and intravenous laser therapy. The application of intravenous blood laser irradiation promoted normalization of indicators of Holter monitoring of electrocardiogram, day monitoring of arterial pressure, lipid profile and hemostasis system. The anti-arrhythmic, anti-hypertensive, anti-atherogenic and anti-aggregative effects of complex therapy using intravenous blood laser irradiation in mine workers with high cardiovascular risk with its subsequent decrease as a result of treatment.

The application of instrumental physiotherapy for the treatment of the patients with erectile dysfunction

This article presents information on the application of apparatus physiotherapy for the treatment of the patients with erectile dysfunction. The authors report the results of the analysis of scholarly research designed to confirm the effectiveness of the physiotherapeutic methods applied for the treatment of the patients presenting with this pathology. Special attention is given to the mechanisms underlying the influence of the procedure with the use of local negative pressure-LOD therapy and shock wave therapy on the main pathogenetic components of erectile dysfunction. In addition, the article provides information about the effectiveness of the modern combined physiotherapeutic techniques including sinusoidal modulated current (SMT) electrophoresis of vasoactive substances and vibromagnetic-laser therapy in the combination with the general purpose methods as exemplified by intravenous laser irradiation. Based on the evidence presented in the article, the authors arrive at the conclusion about the prospects for further research on the development of new physiotherapeutic modalities and their introduction in the practical treatment of the patients with erectile dysfunction.