Intravascular Ultrasound Transducer Research Articles

Feasibility of Novel Grinding Device With Forward-Looking Intravascular Ultrasound Transducer in Coronary Rotational Atherectomy

Feasibility of Novel Grinding Device With Forward-Looking Intravascular Ultrasound Transducer in Coronary Rotational Atherectomy

PZN-PT single crystal based high-frequency intravascular ultrasound transducers

Cardiovascular disease (CVD) is a kind of high life-threatening illness for humans. Intravascular ultrasound (IVUS) technology could highly help the physicians to know the condition of human's vessel wall. In this work, the novel lead zinc niobate-lead titanate (PZN-PT) single crystals-based IVUS transducers were prepared. The electrical properties of PZN-PT single crystals were investigated with high d33 of 2531 pC/N and dielectric constant. The high piezoelectric response could improve the transmission and receive properties of IVUS transducers. Moreover, the high dielectric constant (8050) could highly help the miniaturization of IVUS transducer. The IVUS transducers have a center frequency at 43.5 MHz and a -6dB bandwidth of 62.3%. It promising the PZN-PT based IVUS transducers are suitable for the clinical diagnosis field for CVD.

Design consideration on integration of mechanical intravascular ultrasound and electromagnetic tracking sensor for intravascular reconstruction

PurposeConsidering vessel deformation, endovascular navigation requires intraoperative geometric information. Mechanical intravascular ultrasound (IVUS) with an electromagnetic (EM) sensor can be used to reconstruct blood vessels with thin diameter. However, the integration design should be evaluated based on the factors affecting the reconstruction error.MethodsThe interference between the mechanical IVUS and EM sensor was measured in different relative positions. Two designs of the integrated catheter were evaluated by measuring the reconstruction errors using a rigid vascular phantom.ResultsWhen the distance from the EM sensor to the field generator was 75 mm, the interference from mechanical IVUS to an EM sensor was negligible, with position and rotation errors less than 0.1 mm and 0.6°, respectively. The reconstructed vessel model for proximal IVUS transducer had a smooth surface but an inaccurate shape at large curvature of the vascular phantom. When the distance to the field generator was 175 mm, the error increased significantly.ConclusionPlacing the IVUS transducer on the proximal side of the EM sensor is superior in terms of interference reduction but inferior in terms of mechanical stability compared to a distal transducer. The distal side is preferred due to better mechanical stability during catheter manipulation at larger curvature. With this configuration, surface reconstruction errors less than 1.7 mm (with RMS 0.57 mm) were achieved when the distance to the field generator was less than 175 mm.

High-Attenuation Backing Layer for Miniaturized Ultrasound Imaging Transducer.

Current miniaturized ultrasound transducers suffer from insufficient attenuation from the backing layer due to their limited thickness. The thickness of the backing layer is one of the critical factors determining the device size and transducer performance for miniaturized transducers inserted and operated in a limited space. Glass bubbles, polyamide resin, and tungsten powder are combined to form a new highly attenuative backing material. It has high attenuation (>160 dB/cm at 5 MHz), which is five times greater than silver-based conductive epoxy commonly used for high-frequency ultrasound transducers, appropriate acoustic impedance (4.6 MRayl), and acceptable damping capability. An intravascular ultrasound (IVUS) transducer constructed with the 170 [Formula: see text] of the proposed backing layer demonstrated that the amplitude of the signal returned from the backing layer was 1.8 times smaller, with ring-down attenuated by 6 dB. Wire-phantom imaging revealed that the axial resolution was 30% better with the suggested backing than silver-based conductive epoxy backing. Because of its excellent attenuation capability even at a limited thickness, simple manufacturing process, and easy customization capability, the suggested highly attenuative backing layer may be used for miniaturized ultrasound transducers.

Cylindrical Transducer Array for Intravascular Shear Wave Elasticity Imaging: Preliminary Development.

We present an intravascular ultrasound (IVUS) transducer array designed to enable shear wave elasticity imaging (SWEI) of arteries for the detection and characterization of atherosclerotic soft plaques. Using a custom dicing fixture, we have fabricated single-element and axially-segmented array transducer prototypes from 4.6-Fr to 7.6-Fr piezoceramic tubes, respectively. Focused excitation of the array prototype at 4 MHz yielded a focal gain of 5× in intensity, for an estimated 60 mW/cm2 [Formula: see text] and 1.6-MPa negative peak pressure at 4.5-mm range in water. The single-element transducer generated a peak radial displacement of [Formula: see text] in a uniform elasticity phantom, with axial shear waves detectable by an external linear array probe up to 5 mm away from the excitation plane. In a vessel phantom with a soft inclusion, the array prototype generated peak displacements of 2.2 and [Formula: see text] in the soft inclusion and vessel wall regions, respectively. A SWEI image of the vessel phantom was reconstructed, with measured shear wave speed (SWS) of 1.66 ± 0.91 m/s and 0.97 ± 0.59 m/s for the soft inclusion and vessel wall regions, respectively. The array prototype was also used to obtain a SWEI image of an ex vivo porcine artery, with a mean SWS of 3.97 ± 1.12 m/s. These results suggest that a cylindrical intravascular ultrasound (IVUS) transducer array could be made capable of SWEI for atherosclerotic plaque detection in coronary arteries.

Triple-Element Back-to-Back Transducer With 3D Printed Housing for Intravascular Ultrasound Imaging: A Feasibility Study

Intravascular ultrasound (IVUS) can provide a high-resolution cross-sectional image of the blood vessel to detect the plaque morphology. The resolution of the IVUS image is proportional to a center frequency, however, a penetration depth decreases accordingly. To compensate for this problem, in this study, we propose the triple-element IVUS transducer capable of selecting an operating frequency according to the desired imaging area. In the proposed transducer, three-piezoelectric layers of 10 MHz, 20 MHz, and 30 MHz are formed on the top and both sides of the cube-shaped acoustic stack. These active layers share a common backing layer connected to one co-axial cable and can be driven simultaneously. In order to facilitate the manufacture process of the proposed IVUS transducer, split-assembling fabrication technique and a 3D printed housing with patterned electrodes were employed. The design specifications of the transducer were determined based on finite element analysis (FEA) simulation, and the prototype transducer was fabricated for feasibility study. The successful operation of individual elements constituting the proposed transducer was verified through B-mode imaging experiments using wire and tissue-mimicking phantoms. Subsequently, as a result of performing frequency compounding by combining two and three fundamental images, it was confirmed that the CNR (Contrast-to-Noise) value was improved by about 44%-77%. Therefore, the proposed IVUS transducer is expected to be one of the useful methods for diagnosing vascular diseases.

A Novel Distal Micromotor-Based Side-Looking Intravascular Ultrasound Transducer.

Cardiovascular disease has become one of the leading causes of death in China, accounting for 45.5% of all deaths in rural areas and 43.16% in urban areas. Hence, its early diagnosis is important. With the development of intravascular imaging technology, the intravascular ultrasound (IVUS) is widely used. The available commercial mechanical rotary side-looking IVUS (SL-IVUS) transducers are driven by external motors that use long flexible shafts to transmit the rotation. However, when the transducer passes through a long-curved blood vessel, it easily causes the nonuniform rotation distortion (NURD) of the image. A catheter which contains a distal motor and sodium chloride (NaCl) solution is presented in this study as an attempt to solve such issues. The NaCl solution is used to connect the transducer and micromotor so that the motor can directly drive the transducer to rotate and acquire the information of the blood vessel. The results showed that the center frequency and -6-dB fraction bandwidth of the single element were 47 MHz and 98%, respectively. The SL-IVUS catheter consists of a distal motor, with speed stability and high resolution, and has the potential to diagnose cardiovascular disease. This novel structure can decrease the dimension at the top of the catheter and reduce the risks of clinical diagnosis.

Dual-Frequency Intravascular Sonothrombolysis: An In Vitro Study.

Thrombo-occlusive disease is one of the leading causes of death worldwide. There has been active research on safe and effective thrombolysis in preclinical and clinical studies. Recently, the dual-frequency transcutaneous sonothrombolysis with contrast agents [microbubbles (MBs)] has been reported to be more efficient in trigging the acoustic cavitation, which leads to a higher lysis rate. Therefore, there is increasing interest in applying dual-frequency technique for more significant efficacy improvement in intravascular sonothrombolysis since a miniaturized intravascular ultrasound transducer typically has a limited power output to fully harness cavitation effects. In this work, we demonstrated this efficacy enhancement by developing a new broadband intravascular transducer and testing dual-frequency sonothromblysis in vitro. A broadband intravascular transducer with a center frequency of 750 kHz and a footprint size of 1.4 mm was designed, fabricated, and characterized. The measured -6-dB fractional bandwidth is 68.1%, and the peak negative pressure is 1.5 MPa under the driving voltage of 80 Vpp. By keeping one frequency component at 750 kHz, the second frequency component was selected from 450 to 650 kHz with an interval of 50 kHz. The in vitro sonothrombolysis tests were conducted with a flow model and the results indicated that the MB-mediated, dual-frequency (750+500 kHz) sonothrombolysis yields an 85% higher lysis rate compared with the single-frequency treatment, and the lysis rate of dual-frequency sonothrombolysis increases with the difference between the two frequency components. These findings suggest a dual-frequency excitation technique for more efficient intravascular sonothrombolysis than conventional single-frequency excitation.

High frequency focal transducer with a Fresnel zone plate for intravascular ultrasound

The diameter of an intravascular ultrasound (IVUS) catheter is always less than 1 mm, because it must be inserted into a blood vessel to obtain ultrasound images. Owing to this requisite small size, it is difficult to perform geometric focusing on the surface of an IVUS transducer to improve the spatial resolution of the image. This study proposes a high frequency transducer with a Fresnel zone plate (FZP) for intravascular ultrasound imaging. Through theoretical calculations, the parameters and structure of the transducer are optimized for high-frequency ultrasound. The acoustic beam is simulated using COMSOL software. The aperture size of the ultrasound element is 0.778 × 0.9 mm2. Transducers with or without the FZP layer are designed and fabricated in this study. The center frequency and –6 dB bandwidth of the FZP transducer are 52.5 MHz and 42%, respectively. Meanwhile, the center frequency and –6 dB bandwidth of the plane-shape transducer are 51.3 MHz and 58%, respectively. Wire phantom and porcine artery imaging experiments were performed to evaluate the performance of the designed transducers. The spatial resolution of the FZP transducer is 46.8 μm axially and 183.6 μm laterally, and the resolution of the plane-shape transducer is 44.3 μm axially and 313.5 μm laterally. The results demonstrate that the FZP transducer provides superior lateral imaging resolution for IVUS applications.

Forward-viewing estimation of 3D blood flow velocity fields by intravascular ultrasound: Influence of the catheter on velocity estimation in stenoses

Coronary artery disease is the most common type of cardiovascular disease, affecting > 18 million adults, and is responsible for > 365 k deaths per year in the U.S. alone. Wall shear stress (WSS) is an emerging indicator of likelihood of plaque rupture in coronary artery disease, however, non-invasive estimation of 3-D blood flow velocity and WSS is challenging due to the requirement for high spatial resolution at deep penetration depths in the presence of significant cardiac motion. Thus we propose minimally-invasive imaging with a catheter-based, 3-D intravascular forward-viewing ultrasound (FV US) transducer and present experiments to quantify the effect of the catheter on flow disturbance in stenotic vessel phantoms with realistic velocities and luminal diameters for both peripheral (6.33 mm) and coronary (4.74 mm) arteries. An external linear array ultrasound transducer was used to quantify 2-D velocity fields in vessel phantoms under various conditions of catheter geometry, luminal diameter, and position of the catheter relative to the stenosis at a frame rate of 5000 frames per second via a particle imaging velocimetry (PIV) approach. While a solid catheter introduced an underestimation of velocity measurement by > 20% relative to the case without a catheter, the hollow catheter introduced < 10% velocity overestimation, indicating that a hollow catheter design allowing internal blood flow reduces hemodynamic disturbance. In addition, for both peripheral and coronary arteries, the hollow catheter introduced < 3% deviation in flow velocity at the minimum luminal area compared to the control case. Finally, an initial comparison was made between velocity measurements acquired using a low frequency, catheter-based, 3-D intravascular FV US transducer and external linear array measurements, with relative error < 12% throughout the region of interest for a flow rate of 150 mL/min. While further system development is required, results suggest intravascular ultrasound characterization of blood flow velocity fields in stenotic vessels could be feasible with appropriate catheter design.

A multi-pillar piezoelectric stack transducer for nanodroplet mediated intravascular sonothrombolysis

We aim to develop a nanodroplet (ND)-mediated intravascular ultrasound (US) transducer for deep vein thrombosis treatments. The US device, having an efficient forward directivity of the acoustic beam, is capable of expediting the clot dissolution rate by activating cavitation of NDs injected onto a thrombus. We designed and prototyped a multi-pillar piezoelectric stack (MPPS) transducer composed of four piezoelectric stacks. Each stack was made of five layers of PZT-4 plates, having a dimension of 0.85 × 0.85 × 0.2 mm3. The transducer was characterized by measuring the electrical impedance and acoustic pressure, compared to simulation results. Next, in-vitro tests were conducted in a blood flow mimicking system using the transducer equipped with an ND injecting tube. The miniaturized transducer, having an aperture size of 2.8 mm, provided a high mechanical index of 1.52 and a relatively wide focal zone of 3.4 mm at 80 Vpp, 0.96 MHz electric input. The mass-reduction rate of the proposed method (NDs + US) was assessed to be 4.1 and 4.6 mg/min with and without the flow model, respectively. The rate was higher than that (1.3–2.7 mg/min) of other intravascular ultrasound modalities using micron-sized bubble agents. The ND-mediated intravascular sonothrombolysis using MPPS transducers was demonstrated with an unprecedented lysis rate, which may offer a new clinical option for DVT treatments. The MPPS transducer generated a high acoustic pressure (~3.1 MPa) at a distance of approximately 2.2 wavelengths from the small aperture, providing synergistic efficacy with nanodroplets for thrombolysis without thrombolytic agents.

Mechanically Rotating Intravascular Ultrasound (IVUS) Transducer: A Review.

Intravascular ultrasound (IVUS) is a valuable imaging modality for the diagnosis of atherosclerosis. It provides useful clinical information, such as lumen size, vessel wall thickness, and plaque composition, by providing a cross-sectional vascular image. For several decades, IVUS has made remarkable progress in improving the accuracy of diagnosing cardiovascular disease that remains the leading cause of death globally. As the quality of IVUS images mainly depends on the performance of the IVUS transducer, various IVUS transducers have been developed. Therefore, in this review, recently developed mechanically rotating IVUS transducers, especially ones exploiting piezoelectric ceramics or single crystals, are discussed. In addition, this review addresses the history and technical challenges in the development of IVUS transducers and the prospects of next-generation IVUS transducers.

Efficacy of navigating through the intraplaque route using AnteOwl WR intravascular ultrasound in femoropopliteal chronic total occlusion

BackgroundThere is no consensus on the optimal guidewire passage route for femoropopliteal (FP) chronic total occlusion (CTO). If intraplaque wiring can be performed, a stent-less strategy using a drug-coated balloon can be realized even with FP CTO, and there is a high possibility that good expansion can be obtained even when stent deployment is performed. AnteOwl WR (AnteOwl) is a novel intravascular ultrasound (IVUS) device useful for navigating the second guidewire into the intraplaque route under IVUS observation from the subintimal space. Here, we describe representative cases of FP CTO in which CTO-specific IVUS was extremely useful.Case presentationCase 1 involved a 79-year-old man with total occlusion of the left superficial femoral artery (SFA). We used a contralateral antegrade approach, but the guidewire was advanced into the subintimal space. We advanced AnteOwl into the CTO. By utilizing the asymmetric structure of the transducer and the IVUS wire, we were able to reflect the positional relationship among the IVUS transducer, IVUS wire, and target plaque onto the angiographic image. By aiming the wiring in that direction, we succeeded in traversing the center of the plaque and finally succeeded in obtaining good expansion using the drug-coated balloon. Case 2 involved a 76-year-old woman with total occlusion from the SFA to the popliteal artery. We used an ipsilateral antegrade approach. When AnteOwl was placed on the wire and advanced to the popliteal artery, the subintimal space in the middle of the SFA could be visualized. We employed an IVUS-guided parallel wiring technique and succeeded in passing through all intraplaque routes. Although the CTO was long, we could easily advance through the intraplaque route by reflecting the information obtained from AnteOwl in angiography.ConclusionsAnteOwl is an effective IVUS for FP CTO and facilitates a complex IVUS-guided procedure.

Intravascular Ultrasound Transducer by Using Polarization Inversion Technique for Tissue Harmonic Imaging: Modeling and Experiments.

Intravascular ultrasound (IVUS) tissue harmonic imaging (THI) is a useful vessel imaging technique that can provide deep penetration depth as well as high spatial and contrast resolution. Typically, a high-frequency IVUS transducer for THI requires a broad bandwidth or dual-frequency bandwidth. However, it is very difficult to make an IVUS transducer with a frequency bandwidth covering from the fundamental frequency to the second harmonic or a dual-peak at the desired frequency. To solve this problem, in this study, we applied the polarization inversion technique (PIT) to the IVUS transducer for THI. The PIT makes it relatively easy to design IVUS transducers with suitable frequency characteristics for THI depending on the inversion ratio of the piezoelectric layer and specifications of the passive materials. In this study, two types of IVUS transducers based on the PIT were developed for THI. One is a front-side inversion layer (FSIL) transducer with a broad bandwidth, and the other is a back-side inversion layer (BSIL) transducer with a dual-frequency bandwidth. These transducers were designed using finite element analysis (FEA)-based simulation, and the prototype transducers were fabricated. Subsequently, the performance was evaluated by not only electrical impedance and pulse-echo response tests but also B-mode imaging tests with a 25μm tungsten wire and tissue-mimicking gelatin phantoms. The FEA simulation and experimental results show that the proposed scheme can successfully implement the tissue harmonic IVUS image, and thus it can be one of the promising techniques for developing IVUS transducers for THI.

Single-Crystal High-Frequency Intravascular Ultrasound Transducer With 40-$\mu$ m Axial Resolution

Intravascular ultrasound (IVUS) is one of the most useful tools available today to assist intravascular stenting procedures. Having higher resolution is very important for helping doctors to evaluate the nature of atherosclerotic plaques. The current commercial IVUS systems have a spatial resolution of 70- [Formula: see text] in the axial direction and 200- [Formula: see text] in the lateral direction, which are insufficient for accurate diagnosis. We report here a three-matching-layer IVUS transducer design using a 0.72Pb(Mg1/3Nb2/3O3 - 0.28PbTiO3 single crystal, which can improve the axial resolution to [Formula: see text] without sacrificing the penetration depth. Wire phantom imaging and in vitro porcine coronary artery imaging show noticeably better axial resolution and similar penetration depth compared with a commercial IVUS transducer.

Sonothrombolysis with magnetic microbubbles under a rotational magnetic field

Thrombosis is an extremely critical clinical condition where a clot forms inside a blood vessel which blocks the blood flow through the cardiovascular system. Previous sonothrombolysis methods using ultrasound and microbubbles (MBs) often have a relatively low lysis rate due to the low microbubbles concentration at clot region caused by blood flow in the vessel. To solve this problem, the magnetic microbubbles (MMBs) that can be retained by an outer magnetic field against blood flow are used in this study. Here we report the development of a new method using the rotational magnetic field to trap and vibrate magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically. In this study, we investigated the influence of different blood flow conditions, vessel occlusion conditions (partial and fully occluded), clot ages (fresh, retracted), ultrasound parameters (input voltage, duty cycle) and rotational magnetic field parameters (amplitude, frequency) on the thrombolysis rate. The results showed that the additional use of magnetic microbubbles significantly enhances in vitro lysis of blood clot.

Dual-Element Intravascular Ultrasound Transducer for Tissue Harmonic Imaging and Frequency Compounding: Development and Imaging Performance Assessment.

For accurate diagnosis of atherosclerosis, the high spatial and contrast resolutions of intravascular ultrasound (IVUS) images are a key requirement. Increasing the center frequency of IVUS is a simple solution to meet this requirement. However, this leads to a reduction in imaging depth due to the frequency-dependent attenuation of ultrasound. Here, we report a recently developed dual-element IVUS transducer for tissue harmonic imaging (THI) and frequency compounding to increase the spatial and contrast resolutions of IVUS images, while maintaining the imaging depth to assess the overall morphological change of blood vessels. One 35-MHz element is used for producing general IVUS images and the other 70-MHz element is for receiving the second harmonic signals induced by the 35-MHz ultrasound. The fundamental and second harmonic signals can also be used for frequency compound imaging to further improve contrast resolution. The spatial and contrast resolutions achieved by the developed transducer were evaluated through wire and tissue-mimicking phantom imaging tests. Additionally, the images of a stent deployed in a tissue-mimicking phantom and an excised pig artery were acquired to assess clinical usefulness of the transducer. The results demonstrated that the developed IVUS transducer enables us to simultaneously examine the overall morphological change of blood vessels by the 35-MHz ultrasound images and the near vessel layers such as the intima, the media, and the adventitia by either THI or compound images with high spatial and contrast resolutions. In addition, the developed transducer facilitates the simultaneous acquisition of 35- and 70-MHz fundamental images when needed. The developed dual-element IVUS transducer makes it possible to fully realize the potential benefits of IVUS in the diagnosis of atherosclerosis.

Development of High-Frequency (>60 MHz) Intravascular Ultrasound (IVUS) Transducer by Using Asymmetric Electrodes for Improved Beam Profile.

In most commercial single-element intravascular ultrasound (IVUS) transducers, with 20 MHz to 40 MHz center frequencies, a conductive adhesive is used to bond a micro-sized cable for the signal line to the surface of the transducer aperture (<1 mm × 1 mm size) where ultrasound beam is generated. Therefore, the vibration of the piezoelectric layer is significantly disturbed by the adhesive with the signal line, thereby causing problems, such as reduced sensitivity, shortened penetration depth, and distorted beam profile. This phenomenon becomes more serious as the center frequency of the IVUS transducer is increased, and the aperture size becomes small. Therefore, we propose a novel IVUS acoustic stack employing asymmetric electrodes with conductive and non-conductive backing blocks. The purpose of this study is to verify the extent of performance degradation caused by the adhesive with the signal line, and to demonstrate how much performance degradation can be minimized by the proposed scheme. Finite element analysis (FEA) simulation was conducted, and the results show that −3 dB, −6 dB, and −10 dB penetration depths of the conventional transducer were shortened by 20%, 25%, and 19% respectively, while those of the proposed transducer were reduced only 3%, 4%, and 0% compared with their ideal transducers which have the same effective aperture size. Besides, the proposed transducer improved the −3 dB, −6 dB, and −10 dB penetration depths by 15%, 12%, and 10% respectively, compared with the conventional transducer. We also fabricated a 60 MHz IVUS transducer by using the proposed technique, and high-resolution IVUS B-mode (brightness mode) images were obtained. Thus, the proposed scheme can be one of the potential ways to provide more uniform beam profile resulting in improving the signal to noise ratio (SNR) in IVUS image.

A 40-MHz Ultrasound Transducer with an Angled Aperture for Guiding Percutaneous Revascularization of Chronic Total Occlusion: A Feasibility Study.

Complete blockage of a coronary artery, called chronic total occlusion (CTO), frequently occurs due to atherosclerosis. To reopen the obstructed blood vessels with a stent, guidewire crossing is performed with the help of angiography that can provide the location of CTO lesions and the image of guidewire tip. Since angiography is incapable of imaging inside a CTO lesion, the surgeons are blind during guidewire crossing. For this reason, the success rate of guidewire crossing relies upon the proficiency of the surgeon, which is considerably reduced from 69.0% to 32.5% if extensive calcification, not penetrated by a guidewire, exists in CTO lesions. In this paper, a recently developed 40-MHz forward-looking intravascular ultrasound (FL–IVUS) transducer to visualize calcification within CTO lesions is reported. This transducer consists of a single element angled aperture and a guidewire passage. The aperture is spherically deformed to have a focal length of 3 mm in order to improve spatial resolution of FL–IVUS images. The angle between the beam direction and the axis of rotation is designed to be 30° to effectively visualize calcification within a CTO lesion as well as the blood vessel wall. The experimental results demonstrated that the developed FL–IVUS transducer facilitates visualization of calcification within CTO lesions and makes it possible to help the surgeon make decisions about whether to push the guidewire in order to cross the lesion or to change the surgical procedure.

Evaluation of Intravascular Ultrasound Catheter-Based Transducers Using the Resolution Integral

Intravascular ultrasound (IVUS) catheters are a specialist imaging modality used in the assessment of cardiovascular disease. The ultrasound transducer may either be of single-element mechanical or phased-array design. Because of their design and operating frequencies (10–45 MHz), evaluation of the imaging performance is not possible with commercially available ultrasound test objects. An existing test object, the Edinburgh Pipe Phantom, was modified to allow measurement of resolution integral (R), depth of field (Lr) and characteristic resolution (Dr) of IVUS catheters. In total, seven IVUS catheters, from two manufacturers and of both single-element mechanical and phased-array design, were tested to provide a measure of performance over different frequencies and technologies. Measurements of R for the tested IVUS catheters ranged from 11.9 to 18.8. The modified Edinburgh Pipe Phantom therefore allows catheter-based ultrasound probes to be evaluated scientifically and their performance to be seen in relation to other similar ultrasound technologies such as pre-clinical ultrasound and endoscopic ultrasound.