Intranasal Pleomorphic Adenoma Research Articles

Pleomorphic adenoma of nasal septum: A case report

Pleomorphic adenomas are the most common benign tumor of the major salivary glands. Other rare sites for the occurrence of pleomorphic adenoma have been described in the larynx, pharynx, nasal cavity, lacrimal glands and trachea. We report here a case of intranasal pleomorphic adenoma arising from the nasal septum causing nasal obstruction which was clinically diagnosed as papilloma. Histopathology confirmed the diagnosis of pleomorphic adenoma.

Pleomorphic adenoma of the nasal cavity- an unusual presentation

<p class="abstract">Pleomorphic adenomas (mixed tumors) are the most common benign tumor of the major salivary glands. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual. We report a rare case of large sized pleomorphic adenoma arising from the nasal septum. A 42-year-old man presented with a 3 month history of multiple episodes of nasal bleeding and obstruction on right side of nose. On examination we found a non-tender firm mass extending upto the nasal vestibule which bled on probing. Computed tomographic scans revealed a mass in the right anterior nasal cavity and spur on left side. Paranasal sinuses, posterior choanae and nasopharynx were normal. An intranasal endoscopic approach was used to achieve a wide local resection along with coagulation of base and spurectomy on the left side. The mass was 2.5×2.0 cm with a broad based attachement of 1.0 cm on the nasal septum. The microscopic finding showed a lobular and duct-like structures consisting of a loose chondromyxoid stroma suggestive of a pleomorphic adenoma. Large sized nasal cavity mass with history of epistaxis and which bleeds on probing should be finally assessed under general anaesthesia. It should be excised endoscopically and subjected to histopathological examination<span lang="EN-IN">.</span></p>

Pleomorphic adenoma of the nasal septum: a case report and review of the literature

Intranasal pleomorphic adenomas are quite rare and are frequently misdiagnosed . We report a nasal septal pleomorphic adenoma in a 60-year-old man. Rigid endoscopy of the nose revealed a large polypoid mass filling the right posterior nasal cavity. Computed tomography scan of the paranasal sinuses demonstrated well-pneumatized paranasal sinuses and a soft tissue mass in the posterior aspect of the right nasal cavity arising from the posterior part of the septum. A submucous resection was used as an approach to the tumor and as a method of excising the mass with the segment of septum attached to it. After 4 years, the patient had experienced no further problems with the nasal airway, and repeated nasal endoscopic examination revealed no recurrence of the disease.

Pleomorphic Adenoma of Nasal Cavity: A Rare Case Report

ABSTRACT Pleomorphic adenomas are most common benign tumor of the major salivary gland, mainly found in parotid gland. Pleomorphic adenomas may also occur in the minor salivary glands of the hard and soft palate. Few cases are also diagnosed in various parts of pharynx and larynx. Intranasal pleomorphic adenomas can arise either from septum or lateral nasal wall. They are very rare entity and occasionally misdiagnosed due to their atypical histopathology. We present a rare case of pleomorphic adenoma diagnosed in middle-aged female originating from lateral wall of right nasal cavity. How to cite this article Joshi S, Bhuie HS, Mathur N, Verma H. Pleomorphic Adenoma of Nasal Cavity: A Rare Case Report. Clin Rhinol An Int J 2014;7(2):67-69.

Pleomorphic Adenoma of the Nasal Septum

ABSTRACTPleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum.

巨大な鼻中隔多形腺腫例

An 83-year-old woman was referred with right-side nasal obstruction. The CT scan showed a 60×45×43 mm mass arising from the nasal septum. MRI imaging indicated a smooth and encapsulated mass partial cystic formation involving 30×30×24 mm. A pre-operative definitive diagnosis could not be made despite two biopsies. We performed an endoscopic intranasal operation in combination with a midfacial degloving approach. The post-operative final diagnosis was pleomorphic adenoma (PA) of the nasal septum. Nasal septal PA is exceedingly rare, and only a few cases of giant PA tumor have been reported previously. In this case, we could achieve complete en bloc excision via minimal invasive surgery without facial skin incision. Intranasal PAs have a pathologic feature which seems to be composed of higher epithelial and lower stromal components than PAs of the major salivary glands. The possibility of PA should be kept in mind when assessing nasal cavity tumors that are rich in epithelial constituents. Sometimes small cysts are formed in PAs, while a cyst large enough to be recognized macroscopically is rare. This is the first case report of a nasal septum PA accompanied with cyst formation.

Giant Intranasal Pleomorphic Adenoma: A Rare Case Report

ABSTRACT Pleomorphic adenoma, a heterogeneous mixture of epithelial and myoepithelial cells, commonly found in major salivary glands, accounts for about 3% of benign head and neck tumors. Intranasal pleomorphic adenoma (INPA) is an extremely rare variant forming a mere 8% of all pleomorphic adenomas. Majority of these arise from the nasal septum (82-90%) with only about 8% showing attachment to the lateral nasal wall. Various theories explaining etiopathological basis of INPA have been proposed but none explains its predominance in females in 3rd to 6th decade of life. Hallmark of histopathological picture of pleomorphic adenoma is epithelial tissue mixed with tissues of myxoid, chondroid or mucoid origin. But INPA shows predominantly epithelial component with scanty stroma. Considering its high cellularity and anatomical site, INPA is often misdiagnosed as unilateral nasal malignancy. Early diagnosis ensures complete excision and is paramount to make patient disease free, considering its high potential of recurrence. Hereby, we are presenting a case of giant pleomorphic adenoma of nasal cavity, arising from lateral nasal wall, causing erosion of the base of skull, with the intent of drawing attention to this rare diagnosis. How to cite this article Chavan SS, Bhople KS, Vedi JN, Jain PV, Sonavani M. Giant Intranasal Pleomorphic Adenoma: A Rare Case Report. Clin Rhinol An Int J 2013;6(2):96-99.

Intranasal Pleomorphic Adenoma

ABSTRACTPleomorphic adenoma is a benign tumor arising from major salivary glands and also has been reported in salivary glands of palate rarely in nasopharynx, oropharynx and larynx and lacrimal glands. We report a case pleomorphic adenoma of nasal septum and discuss the clinical features, management along with review of literature.How to cite this articlePatil VM, Patil RM, Kushtagi AV. Intranasal Pleomorphic Adenoma. Int J Otorhinolaryngol Clin 2013;5(3):164-165.

Pleomorphic Adenoma of the Nasal Septum

ABSTRACTPleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum.How to cite this articleTejendrasingh TR, Laxmanrao SSK. Pleomorphic Adenoma of the Nasal Septum. Int J Otorhinolaryngol Clin 2013;5(3):151-153.

Unusual Origin of Pleomorphic Adenoma: Lateral Nasal Wall

Pleomorphic adenoma is the most common benign salivary glands tumor, but it rarely originates in the nose, and is especially rare in the lateral nasal wall. We present a case of intranasal pleomorphic adenoma arising from the lateral nasal wall and discuss the clinical presentation, diagnosis and treatment.

Pleomorphic adenoma of the nasal septum: a case report

IntroductionPleomorphic adenomas are the most common benign tumour of the major salivary glands. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere.Case presentationWe present the case of a 61-year-old man who presented with a 2-year history of left nasal obstruction, occasional epistaxis and facial pain. Radiological examination demonstrated well pneumatised paranasal sinuses and a soft tissue mass in the anterior aspect of the left nasal cavity. In this patient, an intranasal approach was used to achieve a wide local resection.ConclusionPleomorphic adenomas are rare tumours of the nasal cavity and have been shown to be misdiagnosed in over half of cases leading to more aggressive treatment than is necessary. If unilateral nasal obstruction is the main presenting complaint, we suggest consideration of this diagnosis. In view of the potential for tumour recurrence, long-term follow-up and careful examination of the nose with an endoscope are necessary.

Tumoral mass presenting in the nasomalar region arising from the lateral nasal wall: pleomorphic adenoma

Pleomorphic adenoma is the most common benign salivary gland tumor. Although the major salivary glands are the most common sites of its origin, it can also occur in the minor salivary glands of the oral cavity and rarely in the neck, ear, nasal cavity and larynx. We report a rare case of intranasal pleomorphic adenoma arising from lateral nasal wall and discuss the clinical presentation, diagnosis and treatment approaches with the review of the literature.

Pleomorphic Adenoma of the Nasal Septum-A Case Report

We report a rare case of pleomorphic adenoma arising from the nasal septum. A 37-year-old woman presented with a 1-year-history of right-sided occasional epistaxis. Computed tomographic scans revealed an oval mass in the right nasal cavity. The tumor was removed endoscopically with endonasal approach. The microscopic finding showed numbers of myoepithelial cells and duct-like structures consisting of loose myxoid stroma. This lesion had histological characteristics of a pleomorphic adenoma, and this was confirmed by immunohistochemical expression of cytokeratin, S-100 protein and SMA. Her post-operative course was uneventful, and she is currently free from the disease 1.5 years after surgery.

Pleomorphic adenoma of the nasal septum: a case report

Pleomorphic adenomas arise most commonly in the major salivary glands; the minor salivary glands are affected in only 8% of the cases. Intranasal pleomorphic adenoma being extremely rare originates most commonly from the nasal septum. We present a case of a 55-year-old man who presented with complaints of right-sided nasal obstruction and occasional nasal bleed for the last 6 months. Examination showed a mucosa-covered, fleshy 2 × 2 × 1.5 cm mass in the right nasal cavity. Computed tomogram showed right-sided polypoidal mass with attachment to the cartilaginous nasal septum without any erosion of the surrounding structures. The clinical presentation, gross and microscopic appearance, and treatment of intranasal pleomorphic adenoma is briefly discussed.

Pleomorphic adenoma of the nasal septum

Despite the common occurrence of pleomorphic adenoma of major salivary glands, intranasal pleomorphic adenoma are rare. We present a ease of pleomorphic adenoma of the nasal septum along with a brief review of literature. The histological nature of this lesion in comparison to other salivary gland tumours and the importance of an accurate diagnosis has been stressed.

Pleomorphic adenoma originated from the inferior nasal turbinate

Although pleomorphic adenoma is the most common benign neoplasm of the salivary glands, it has also been reported to be present in the neck, ear, mediastinum, external nose and nasal cavity. Intranasal localization of this lesion is very rare and mainly originates from the nasal septum. From wherever the lesion originates, the main treatment modality should be surgical. We presented a very rare case of intranasal pleomorphic adenoma originated from the inferior nasal turbinate. Due to the expansile nature of the lesion, a midfacial degloving approach was preferred.

Pleomorphic adenoma in nasal cavity: immunohistochemical study of three cases

Intranasal pleomorphic adenoma is a rare neoplasm, and thus only one case report addressed immunohistochemical findings of this neoplasm. To define immunohistochemical features of intranasal pleomorphic adenoma, we studied three cases of the pleomorphic adenoma developed from the nasal septum. Subsequently, immunohistochemical reactivities of the tumor cells for various cytokeratins, glial fibrillary acidic protein (GFAP), S100 protein, α-smooth muscle actin (SMA), and vimentin were similar to those of pleomorphic adenoma of the parotid gland. The tumors examined in this study had different histological components, such as predominance of myxoid area, solid area, or tubuloductal structure, but immunoreactivity of both epithelial and myoepithelial tumor cells were the same in the tumors. Therefore, immunoreactivity of the tumor cells were the same among the intranasal pleomorphic adenoma having various histological components.