Intranasal Betamethasone Research Articles

COMPARING THE EFFECTS OF INTRANASAL BETAMETHASONE SODIUM SULPHATE AND BECLOMETHASONE DIPROPIONATE IN PATIENTS WITH ALLERGIC RHINITIS

Objective: To compare the effects of Intranasal Betamethasone and Beclomethasone in patients with Allergic Rhinitis.
 Study Design: Quasi experimental study.
 Place and Duration of Study: Combined Military Hospital Bahawalpur and Shahida Islam Medical and Dental College Lodhran, from Mar 2018 to Feb 2019.
 Methodology: A total of 200 patients who were between 22-55 years of age were included in this study. Half of them received Intranasal Betamethasone were compared with the other half who received Intranasal Beclomethasone. Clinical success was compared in both groups in terms of patients becoming a symptomatic.
 Results: Clinical symptoms were markedly reduced in both groups at the end of the study as 94 (94%) and 78 (78%) of patients who were on Intranasal Betamethasone and Intranasal Beclomethasone respectively showing that Intranasal Betamethasone is superior to Intranasal Beclomethasone in controlling Allergic Rhinitis symptoms. Chi square test is applied and p-value calculated (p=0.045) significant.
 Conclusion: Intranasal Betamethasone is far more effective drug as compare to Intranasal Beclomethasone in controlling allergic symptoms.

Iatrogenic Cushing syndrome due to use of intranasal betamethasone - two case reports

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

A Case of Iatrogenic Cushing Syndrome Caused by Long Term Use of Intra-nasal Betamethasone Sodium Phosphate

72歳，男性．軽微な打撲で上肢に皮下出血を来たし，赤ら顔，満月様顔貌を認め，Cushing症候群が疑われた．3年前より，ベタメタゾン含有製剤を点鼻で継続使用していたことから，外因性ステロイドが原因であることが判明した．被疑薬剤を中止，ヒドロコルチゾンの補充漸減療法にて症状は軽快した．副腎皮質ホルモン製剤は，投与経路にかかわらず，内因性の視床下部―下垂体―副腎系を抑制し得ることを認識する必要がある．

嗅覚障害に対するステロイド点鼻により生じた副腎機能不全例

Intranasal steroids are widely used to treat olfactory disorder, and are known to have fewer side effects than systemic steroids. However, there are some reports that intranasal steroids have induced adrenal insufficiency, even when the steroid dosage is appropriate. We encountered a case of secondary adrenal insufficiency after using intranasal betamethasone for olfactory disorder within the usual dosage. In this case, we were not aware of instructing the patient not to swallow the steroid which had dripped into her pharynx. Thus, a large amount of steroids which had passed through her nasal cavity might have been absorbed in the oropharyngeal mucosa and also ingested. That is possibly the main cause of developing adrenal insufficiency. Recently, Toki-shakuyaku-san, a traditional Chinese medicine, has started to be used for olfactory disorder after a cold. Because of its minimum side effects, it may be safely used for patients with the risk associated with steroid use.

Too little or too much corticosteroid? Coexisting adrenal insufficiency and Cushing's syndrome from chronic, intermittent use of intranasal betamethasone

SummaryTo report the puzzling, rare occurrence of coexisting adrenal insufficiency and Cushing's syndrome from chronic, intermittent use of intranasal betamethasone spray. A 62-year-old male was referred to our endocrinology clinic for management of adrenal insufficiency. This previously healthy individual began to experience chronic sinus symptoms in 2007, was treated with multiple ensuing sinus surgeries, and received oral glucocorticoid for 6 months. In the following 5 years, he suffered severe fatigue and was diagnosed with secondary adrenal insufficiency. He could not be weaned from corticosteroid and developed clear cushingoid features. In our clinic, careful inquiry on medications revealed chronic, intermittent use of high-dose intranasal betamethasone since 2008, which was not apparent to his other treating physicians. His cushingoid features significantly improved after holding intranasal betamethasone.Learning points Chronic, intermittent intranasal betamethasone can cause secondary adrenal insufficiency and iatrogenic Cushing's syndrome when used in excess.Topical corticosteroid use should be considered in the differential diagnosis of adrenal insufficiency or Cushing's syndrome.

Temporary inhibition of growth and adrenal suppression associated with the use of steroid nose drops

Inhibition of growth and adrenal suppression are reported following the use of intranasal beta-methasone (0.1%) in a 9-year-old boy with cystic fibrosis and nasal polyps and in a 3-year-old girl with allergic rhinitis. On stopping treatment catch-up growth occurred and adrenal function returned to normal.

Intranasal steroid aerosol in perennial rhinitis: comparison with an antihistamine compound

Intranasal betamethasone valerate aerosol, given for 28 days, was compared with an oral antihistamine compound in a couble-blind, double-dummy, cross-over trial involving thirty patients with perennial rhinitis. The steroid aerosol was more effective in reducing symptoms and was preferred by the patients (P less than 0-01). Nasal blockage index, calculated from oral and nasal peak expiratory flow measurements, did not provide useful or additional information. There were no side effects from the steroid and Candida albicans was not cultured from nasal swabs. It is concluded that beta-methasone valerate aerosol is a suitable short-term alternative for patients whose perennial rhinitis fails to respond to conventional therapy.