Intractable Trigeminal Neuralgia Research Articles

Radiofrequency regulation of the sphenopalatine ganglion in managing herpes zoster ophthalmicus neuralgia: A case series.

Trigeminal herpes zoster, which comprises 10% to 20% of cases of herpes zoster, often leads to severe pain in the ophthalmic branches. Current treatments, including drug therapy and minimally invasive interventions, have limitations; accordingly, there is a need to explore alternative approaches. This study aimed to evaluate the efficacy and safety of computerized tomography (CT)-guided pulsed radiofrequency of the sphenopalatine ganglion in patients with intractable trigeminal herpetic pain. Three patients with intractable trigeminal ophthalmic zoster neuralgia were studied. All patients complained of bursts of headache, which occurred at least 10 times a day, usually in the periorbital and frontal regions. Conventional treatments, including oral medications and radiofrequency therapy targeting the trigeminal-semilunar ganglion and supraorbital nerve, could not sufficiently provide relief. Two patients were diagnosed with herpes zoster in the ocular branch of the trigeminal nerve with conjunctivitis, while one patient was diagnosed with postherpetic neuralgia in the ocular branch of the trigeminal nerve. This study employed a novel approach that involved CT-guided radiofrequency regulation of the pterygopalatine fossa sphenopalatine ganglion. In all three patients, pain relief was achieved within 1 to 3 days after treatment. During the follow-up, one patient had pain recurrence; however, its severity was ≈ 40% lower than the pretreatment pain severity. The second patient had sustained and effective pain relief. However, the pain of the third patient worsened again after 2 months. The average follow-up duration was 3 months. None of the enrolled patients showed treatment-related adverse reactions or complications. Our findings indicated that CT-guided radiofrequency regulation of the pterygopalatine fossa sphenopalatine ganglion was a safe and effective intervention for pain in patients with trigeminal ophthalmic zoster neuralgia, suggesting that it may be a therapeutic option if other treatments fail.

460 Frame Navigation Guided Percutaneous Balloon Compression for Intractable Trigeminal Neuralgia Secondary to Multiple Sclerosis

INTRODUCTION: Patients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and the development of a demyelination plaque. Despite treatment, approximately 10% of MS patients treated for TN experience symptom recurrence, including the development of MS-like symptoms such as optic neuritis and bilateral facial pain. METHODS: A computed tomography (CT) scan was performed preoperatively on two patients diagnosed with multiple sclerosis (MS) who experienced secondary trigeminal neuralgia (TN). The acquired images were then introduced into a navigation system for intraoperative navigation. The preliminary CT images were registered using the navigation system and the bony landmarks were set. Fluoroscopy-guided cannulation was performed under general anesthesia to complete the procedure. RESULTS: Two patients diagnosed with multiple sclerosis (MS) who experienced refractory trigeminal neuralgia (TN) underwent percutaneous balloon compression. The patients were 38 and 56 years old and complained of facial pain in the V1-V2 and V3 distribution. Initial conservative treatment and one dosage of Gamma Knife Radiosurgery (GKR) resulted in symptom control for a few weeks. However, both patients had an acute recurrence of pain; thus, percutaneous retrogasserian balloon compression was performed. During follow-up, the patients reported a 70% decrease in pain after the procedure, with minimal recurrence of shooting episodes. CONCLUSIONS: The management of trigeminal neuralgia secondary to drug-resistant multiple sclerosis presents a persistent challenge. The percutaneous technique for retrogasserian balloon compression may offer a solution for some patients, but it can be technically challenging. Microvascular decompression remains a debated approach for this population, given the complexity of the pathogenesis, target identification, and the potential absence of neurovascular conflict, while stereotactic radiosurgery may be a promising alternative.

Frame navigation guided percutaneous balloon compression for intractable trigeminal neuralgia secondary to multiple sclerosis

BackgroundPatients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and development of a demyelination plaque. Despite treatment, approximately 10% of MS patients treated for TN experience symptom recurrence, including the development of MS-like symptoms such as optic neuritis and bilateral facial pain. MethodsA computed tomography (CT) scan was performed preoperatively on two patients diagnosed with multiple sclerosis (MS) who experienced secondary trigeminal neuralgia (TN). A precise reference frame was strapped firmly to the patient's forehead during the intraoperative procedure. Preliminary CT images were registered using the navigation system and the bony landmarks were set. Case descriptionTwo patients diagnosed with multiple sclerosis (MS) who experienced refractory trigeminal neuralgia (TN) underwent percutaneous balloon compression. Initial conservative treatment and one dosage of Gamma Knife Radiosurgery (GKR) resulted in symptom control for a few weeks. Both patients had an acute recurrence of pain; thus, percutaneous retrogasserian balloon compression was performed. During follow-up, the patients reported a 70% decrease in pain after the procedure, with minimal recurrence of shooting episodes. ConclusionManagement of trigeminal neuralgia secondary to drug-resistant multiple sclerosis presents a persistent challenge. The percutaneous technique for retrogasserian balloon compression may offer a solution for some patients, but it presents unique challenges for neurosurgeons. Given the complexity of the pathogenesis, target identification, and the potential absence of neurovascular conflict, microvascular decompression remains a debated approach for this patient population. While stereotactic radiosurgery may be a promising alternative.

Internal Neurolysis for Trigeminal Neuralgia: Technical Nuances and a Single-Institution Experience

Trigeminal neuralgia is a facial pain syndrome most commonly caused by a neurovascular compression (NVC) of the trigeminal nerve. Microvascular decompression (MVD) is the most durable surgical treatment; however, patients without an NVC are not candidates for this procedure. Alternative treatments such as percutaneous rhizotomy and radiosurgery are effective but with higher recurrence rates. Internal neurolysis (IN) is a less frequently used procedure that aims to provide long-term relief to patients without NVC. We present the surgical techniques for IN developed at our institution. We also discuss the technical nuances related to nerve consistency and present a new classification based on these findings. We provide pain and numbness outcomes for our cohort of patients stratified by the extent of neurolysis and nerve consistency. Patients with medically intractable trigeminal neuralgia eligible for posterior fossa exploration are eligible for MVD and possible IN. If no NVC or a mild NVC is encountered, IN is performed. We have divided the procedure into 4 main steps: opening the outer connective sheath, fascicular dissection, inside-out dissection and the fascicular irrigation technique. Trigeminal nerve consistency has been classified into 3 main types: type 1 is soft and friable; type 2 is intermediate consistency and ideal for neurolysis; and type 3 is firm and presents a more challenging dissection. In the absence of microvascular compression, we advocate for a thorough neurolysis using the techniques described in our article.

A case of intractable trigeminal neuralgia improved by a combination of venlafaxine and cognitive behavioral therapy

A case of intractable trigeminal neuralgia improved by a combination of venlafaxine and cognitive behavioral therapy

Correlation of Preoperative High-Resolution Neurovascular Imaging and Surgical Success in Neurovascular Compression Syndromes.

Neurovascular compression syndromes (NVCSs) are a group of neurological disorders characterized by compression of a cranial nerve and include trigeminal neuralgia (TN), hemifacial spasm, geniculate neuralgia, glossopharyngeal neuralgia, vestibular paroxysmia, and trochlear palsy. The European Academy of Neurology recommends constructive interference in steady-state/fast imaging employing steady-state (CISS/FIESTA) magnetic resonance imaging (MRI) in the evaluation of medically intractable TN, but similar recommendations do not exist for the remaining NVCSs. We conducted a retrospective chart review of 300 patients with an NVCS who underwent microvascular decompression (MVD) by a single neurosurgeon from 2004 to 2021. Data were collected on preoperative diagnosis, pre- and postoperative symptoms, presence/absence of preoperative high-spatial-resolution CISS/FIESTA MRI, and intraoperative findings. Rates of symptomatic improvement were used as a correlate of surgical success. The rate of symptomatic improvement in the patients with a preoperative CISS/FIESTA MRI was 5.8% greater than those without preoperative high-spatial-resolution neuroimaging (98.8% vs. 93%, respectively; P= 0.008). Stratified by diagnosis, patients with TN had the greatest difference in surgical success between the 2 groups (99.3% vs. 92.9%, n= 268; P= 0.006). No statistically significant differences were observed in the other NVCSs, although positive trends were noted. Preoperative CISS/FIESTA MRI correlated with greater rates of surgical success in cases of medically intractable TN; however, definitive conclusions could not be made regarding the remaining NVCSs. We support the recommendation that this imaging modality be included as part of the standard of practice for the evaluation and management of TN and encourage future studies to further elucidate this relationship for the less common NVCSs using a larger cohort.

A single centre case series of microvascular decompression surgery for classical trigeminal neuralgia: functional outcomes and report of a unique conflict

BackgroundMicrovascular decompression surgery for trigeminal neuralgia is now considered the benchmark surgical procedure for intractable trigeminal neuralgia of any variety. The objective of this study is to share our experience in managing classical trigeminal neuralgia with microvascular decompression surgery looking into both immediate and late functional outcomes at 3 and 6 months post op. We also report a unique case of trigeminal neuralgia due to a tributary of the petrosal vein passing through the substance of the trigeminal nerve itself at its root entry zone.ResultsThis study included 20 patients; it showed that microvascular decompression surgery of the trigeminal nerve is an effective method for treatment of classic trigeminal neuralgia (p value < 0.001). The trigeminal root was compressed by the superior cerebellar artery in 75% of patients. A vein contributed to the compression in 45% of patients and was the only compressing vessel in 15%.ConclusionMicrovascular decompression surgery is the treatment of choice in patients with medically refractory trigeminal neuralgia, unless their general condition prohibits it. It’s also worth noting that the normal anatomy of the veins in this region is quite variable and the venous structures causing a neurovascular contact are more or less inconsistent. To the best of our knowledge and despite the wide range and progress in microvascular decompression surgery for trigeminal neuralgia, this is the first reported case in the literature for a neurovascular conflict caused by a vein passing through the trigeminal nerve itself.

Ultrasound Guided Infraorbital Nerve Radiofrequency Thermocoagulation in Patients with Trigeminal Neuralgia

Trigeminal neuralgia (TN) is a sudden intensive orofacial pain disorder characterized by a unilateral recurrent paroxysmal lancinating pain occurring in the area of trigeminal nerve distribution. Diagnosis is made with characteristic clinical presentations and requires brain magnetic resonance imaging to rule out intracranial tumor or multiple sclerosis which potentially causes secondary TN. Among the various interventional managements, the conventional radiofrequency thermocoagulation (RFT) of Gasserian ganglion results in the highest rate of complete pain relief. We report two cases who presented severe facial pain due to intractable TN of V2 division. For pain relief, Gasserian ganglion RFT was planned. However, both patients could not tolerate the neck extension and chin-up position. Therefore, ultrasound guided infraorbital nerve RFT which does not require such position was performed successfully. When the patients came to the pain clinic 2 weeks later, the numerical rating scale for TN was 2/10 with mild hypoesthesia of V2 division. Infraorbital nerve RFT is an alternative option in patients who is unable to tolerate the ganglion RFT. Keywords: Radio waves, Trigeminal nerve, Trigeminal neuralgia, Ultrasonography

A Cadaver Study Confirming the Location of Dye after Trigeminal Ganglion Rhizotomy

Radiofrequency thermal rhizotomy demonstrates an excellent treatment outcome with a high success rate among patients of intractable trigeminal neuralgia. The triangular plexus which is an immediate retrogasserian portion of the trigeminal root is suggested as the best place of lesioning during radiofrequency thermal rhizotomy. However, the anatomy of the triangular plexus has been relatively unrecognized, while the anatomical study related to therapeutic procedure is scarce. The purpose of this study is to confirm with gross and microscopic finding of the trigeminal system whether, if an electrode tip is placed on the petroclival junction in lateral cranial view, it actually arrives at the triangular plexus or not. In relation to therapeutic procedure, we examined the triangular plexus with morphological and histological methods. Human cadaveric study. An anatomical laboratory in South Korea. Percutaneous procedure of radiofrequency thermal rhizotomy under C-arm guidance was performed in 8 cadavers. Final target of the electrode tip was the petroclival junction under true lateral cranial view. The location of the electrode tip was determined under observation of the presence of an injected dye. Triangular plexus size was measured grossly and microscopically. Gross and microscopic evaluation of the triangular plexus was performed. Among 15 trigeminal systems, 8 showed dye appearance in the triangular plexus, while 6 showed it in the trigeminal ganglion. Overall, 53% of radiofrequency thermal rhizotomy could reach the triangular plexus when an electrode tip was placed on the petroclival junction. The grossly measured average triangular plexus vertical and transverse diameters were 0.8 cm and 1.3 cm, respectively. Only radiologic landmark was used to confirm the location of the electrode tip. However, further study confirming the location of the electrode tip under the guidance of electrical stimulation is needed. When an electrode tip was placed on the petroclival junction, 53% of radiofrequency thermal rhizotomy could reach the triangular plexus.

Microsurgical resection of petroclival meningiomas treated with stereotactic radiosurgery to address persistent post-treatment trigeminal pain

BackgroundPetroclival meningiomas (PCM) are challenging tumors to manage. Observation, Stereotactic radiosurgery (SRS) and surgical resection have typically been offered as treatment options. A percentage of patients with PCMs present with trigeminal pain. We present four patients with small PCMs presenting with Trigeminal neuralgia (TN) that were treated with radiosurgery and continued to have debilitating trigeminal pain afterwards. All of them underwent microsurgical resection (MR) of their tumor to manage their trigeminal pain. ObjectiveTrigeminal Neuralgia in the setting of PCM is rare. Oftentimes in these subset of patients TN pain persists after radiation and medical therapy. We explore the possibility of addressing intractable TN pain with microsurgical resection. MethodsPatients with petroclival meningiomas presenting with trigeminal pain and having persistent pain after treatment with radiosurgery were included in our review. Those patients were treated with microsurgical resection of their tumor to help control their persistent pain. The patients’ demographics, clinical, and radiological data were reviewed. The primary aim of the review was to assess the patients’ Barrow Neurological Institute (BNI) trigeminal neuralgia scores following microsurgical resection. ResultsFour female patients were identified. The tumors were locally controlled after SRS, however all four patients continued to have debilitating trigeminal pain despite medical management. All patients had complete resolution of their TN pain in the immediate postoperative period, with a BNI score of I on their last follow up. ConclusionMicrosurgical resection is an appropriate option for patient’s petroclival meningiomas with persistent facial pain after treatment with SRS.

Intravenous lidocaine and magnesium on responses of A-δ and A-β nerve fibers at non-affected and affected areas in three cases of neuralgias

Intravenous magnesium and lidocaine have been used for the management of intractable pain individually or in combination. A study reported on the positive effects when used in combination on neuralgia when antiepileptic drugs failed, but nobody has clarified how the combination works. The aim of the present case report is to see how a combination of intravenous magnesium and lidocaine influenced electrically-evoked responses of peripheral A-δ and A-β nerve fibers at non-affected and affected areas in three patients with neuralgia. For nociceptive stimulation, a method of intraepidermal electrical stimulation (IES) was used for the selective activation of cutaneous A-δ fibers, using a stainless steel concentric bipolar needle electrode. For tactile stimulation, similar cutaneous sites were stimulated for cutaneous A-β fibers using the same electrode. Three patients with intractable trigeminal neuralgia or intercostal neuralgia were treated using an intravenous infusion of a combination of 1.2g of magnesium and 100mg of lidocaine for one hour. Although all patients experienced sound pain relief after the combined intravenous infusion therapy, the combination had a different effect on electrically-evoked responses of peripheral A-δ and A-β nerve fibers at non-affected and affected areas in each patient.

Cryoneurotomy in the management of intractable trigeminal neuralgia.

In this paper we describe the effects of peripheral cryoneurotomy on a consecutive series of patients with intractable trigeminal neuralgia (TN) who had been treated by a single surgeon over a ten-year period. The results of 55 patients who underwent a total of 102 cryoneurotomies were documented. The age at first cryofreeze was 64 (30-92) years with 24 males and 31 females. Thirty-five had primary TN and 20 secondary TN. The first cryofreeze resulted in 28.2 (5-144) pain free months. Twenty-nine had a second freeze which lasted 34 (2-100) pain-free months and 13 had a third cryofreeze which lasted 26 (1-108) pain free months. Two patients had further freezes. Thirty-four of the primary TN patients had prolonged freedom from pain with one dying perioperatively. The 20 patients with secondary TN had shorter period of pain relief (p<0.05) and one committed suicide. The procedure of peripheral cryoneurotomy is recommended for older, unwell patients with primary TN that is refractory to medical or neurosurgical treatments. It is less effective for dysaesthesia secondary to traumatic nerve injuries.

3-dimensional computer graphics model elucidating involvement of intraparenchymal venous malformation in trigeminal nucleus of brachium pontis with intractable trigeminal neuralgia

Venous malformation (VM) in the posterior cranial fossa occasionally cause trigeminal neuralgia (TN), which were treated with microvascular decompression of its drainer, whereas it was effective only in the limited cases, and its pathological mechanism causing TN is controversial.A 72-year-old man had a 20-year history of typical but severe TN in his left face. Without radiographic evidence of vascular compression on the root entry zone (REZ) of the trigeminal nerve, he underwent stereotactic radiosurgery in previous hospital, resulting in only temporary improvement. On T1-wighted magnetic resonance image with enhancement, the left trigeminal nerve was focally enhanced, which was typical finding after high dose irradiation for TN. Simultaneously, it disclosed small “caput medusa” within the pontine tegmentum, indicated existence of VM in brachium pontis.A 3-dimensional computer graphics model created by fusion of magnetic resonance angiography, diffusion tensor tractography, and fast imaging employing steady-state acquisition elucidated VM was located in the trigeminal nucleus of brachium pontis, which will be very useful for understanding the anatomic correlation of VM and pontine trigeminal nucleus. Since there was no vascular compression at the REZ of the trigeminal nerve, microvascular decompression was not indicated. With minimum dose of gabapentine and carbamazepin, his facial pain completely disappeared and controlled for more than 5 years.

Radiofrequency thermocoagulation of the right mandibular nerve relieved the intractable trigeminal neuralgia related to multiple sclerosis: a case report

Radiofrequency thermocoagulation of the right mandibular nerve relieved the intractable trigeminal neuralgia related to multiple sclerosis: a case report

Long term efficacy and safety of onabotulinumtoxin a as monotherapy in intractable trigeminal neuralgia

Trigeminal neuralgia(TN) is one of the most agonizing facial pain disorders that humans endure. Studies on onabotulinumtoxin A(BTX-A) treatment for TN are limited, but promising with respect to TN of no identifiable cause. However, more clinical data on the risk-benefit profile for long term treatment beyond one year is needed. We aimed to investigate the efficiency and safety of BTX-A treatment in a 65-year-old male without previous disease who in July 2012 presented with TN. The patient was medically treatment refractory due to insufficient pain relief and adverse events of drowsiness. No definite neurovascular compression was notified in brain MRI and surgery was not considered. BTX-A was injected into the pain trigger zones of the trigeminal nerve with the follow the pain injection paradigm. Complete analgesia was reported 2 weeks after BTX-A injection. Pain medications were discontinued. Regular BTX-A treatment every 12 weeks during the next 33 months showed sustained analgesic effect. He showed no severe adverse event except mild difficulty in facial expression. BTX-A has an excellent safety profile and may be efficient for patients with symptomatic TN not suited for conventional therapies. This case provides additional clinical evidence for the consistency of the efficacy and for the long-term safety and tolerability of BTX-A for the pain relief of TN who have been treat with BTX-A every 12 weeks over 33 months (11 treatments) with the follow the pain injection paradigm.

Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis

ObjectivesThe commonest secondary cause for trigeminal neuralgia (TN) is multiple sclerosis (MS) and little is known about this group of patients in terms of their presentation and treatments. We compared patients with TN and MS (pwTNMS) with a cohort of patients with primary TN, who had been referred to the same specialist unit, both in terms of characteristics and impact on quality of life at the time of their first assessment. MethodsUsing a prospective patient database we extracted key clinical data and results from psychometrically tested questionnaires of 26 pwTNMS and compared them to an age and gender-matched set of 68 patients with primary TN. ResultsOur findings suggest that pwTNMS exhibit a more severe clinical phenotype than primary TN. Prior to referral, pwTNMS are more likely to have used more healthcare services and undergone more neurosurgical interventions. Strikingly, pwTNMS exhibit reduced lengths and duration of remission periods and fewer identifiable triggers. Furthermore, pwTNMS report significant impact on quality of life comparable to those in primary TN, scoring highly in measures of anxiety, depression, and catastrophizing, but also report greater sleep disturbance, and overall interference in activities of daily living. ConclusionspwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team.

Mandibular Nerve Block Guided By Ctin Patients with Trigeminal Neuralgia

Background: Trigeminal neuralgia (TN) is a well-known facial pain syndrome characterized by excruciating paroxysmal shock pain attacks located in somatosensensory distribution of trigeminal nerve. Mandibularaffection is a common presentation of TN. Objectives: Injection of mandibular nerve with neurolytic solutions in trigeminal neuralgia that was unresponsive to pharmacotherapy. Determination of patients and Method: This prospective study included 21 patients treated for mandibular neuralgia by percutaneous injection of absolute alcohol under guidance of CT image. Their ages ranged from 18-60 years and male to female was 3:4; All patients suffered from moderate to severe TN and did not respond to medical treatment. Entry and trajectory of needle was planned by CT and after local anesthesia. Alcohol was injected at the exit of mandibular nerve from foramen ovale. Results: 85.7% of patients improved: 71.4% became pain free, who became 61.9% after two years of follow up. Conclusion: CT guided mandibular nerve block by neurolytic agent as absolute alcohol and showing its effectiveness as minimal invasive treatment option for intractable trigeminal neuralgia. CT guidance provided a clear view to secure the safety, accuracy and selectivity of nerve block.

Glossopharyngeal neuralgia treated using stereotactic Gamma Knife radiosurgery

Glossopharyngeal neuralgia (GPN) is a rare disorder of the ninth cranial nerve. It affects patients' quality of life, with the characteristic symptoms of severe paroxysmal pain affecting the throat, tongue, and ear. Traditional treatment for GPN includes medical management with anticonvulsants and analgesics and surgery with microvascular decompression (MVD) for refractory cases. However, surgical complications such as neurovascular damage may occur. Gamma knife radiosurgery (GKRS) might be a viable surgical alternative for idiopathic GPN. Although GKRS is widely recognized as an effective and minimally invasive treatment for intractable trigeminal neuralgia, its role in GPN has not yet been clearly determined. Herein, we report a 45-year-old male patient who presented with the left throat intractable shooting pain for 6 months. The pain also radiated to his left ear and was triggered by swallowing. He was diagnosed as having GPN. The patient refused for MVD treatment. Thus, we instead performed GKRS. The target was placed over the cisternal segment of the glossopharyngeal nerve, close to the meatus of the jugular foramen, with a single 4-mm isocenter. The maximal dose to the target was 86 Gy. The patient's pain completely disappeared 2-week posttreatment. No major neurological complication was noted in series follow-up. The clinical response in this case report provides evidence of the efficacy of treating GPN with stereotactic radiosurgery. GKRS is a valuable surgical alternative for idiopathic GPN, with very high efficacy and without permanent complications. Additional studies with larger numbers of patients are needed to demonstrate the long-term safety and effectiveness for this treatment.

Radiosurgery for the management of intractable trigeminal neuralgia.

Radiosurgery for the management of intractable trigeminal neuralgia.

Efficacy and safety of CT-guided percutaneous pulsed radiofrequency treatment of the Gasserian ganglion in patients with medically intractable idiopathic trigeminal neuralgia.

BackgroundThere is a lack of prospective studies for the long-term results of percutaneous pulsed radiofrequency (PRF) of the Gasserian ganglion in the treatment of patients with medically refractory trigeminal neuralgia (TN).Methods and resultsWe prospectively observed the outcomes of 28 idiopathic TN patients (between July 2013 and July 2016) who received CT-guided percutaneous PRF treatment of the Gasserian ganglion. All of the patients had stopped responding to drug therapy before PRF treatment. The effective treatment standard was a reduction in the pain numeric rating scale (NRS) by ≥50% after the procedure. The postoperative NRS score decreased gradually from preoperative 7.6±0.8 months to 1.5±2.4, 0.2±0.4, 0.2±0.4, 0.1±0.4, and 0.1±0.4 at 1, 3, and 6 months and 1 and 2 years after the PRF treatment. The response rates at 1, 3, and 6 months were 85.7%, and the rates at 12 months and 2 years were maintained at 78.6%. No serious side effects were observed.ConclusionCT-guided PRF invention is an effective and safe technique for medically intractable idiopathic TN patients. This minimally invasive alternative treatment has the potential as a first-line therapy for TN.