Intra-articular Synovial Sarcoma Research Articles

Intraarticular Synovial Sarcoma of Knee Treated with wide Local Excision and Arthrodesis- A Case Report and Follow Up of 4 Years

Intraarticular Synovial Sarcoma of Knee Treated with wide Local Excision and Arthrodesis- A Case Report and Follow Up of 4 Years

Intraarticular Synovial Sarcoma Causing Chronic Wrist Pain: A Rare Case Report

Synovial Sarcoma (SS) is a rare and aggressive sarcoma that usually occurs around the knee joint; it rarely involves the hand. Joint involvement by SS is extremely rare. We report a case of wrist intraarticular SS presenting with chronic wrist pain. The patient underwent surgical excision alongside with local radiotherapy and chemotherapy. After 24 months of follow up, there was no recurrence or metastasis. Intraarticular SS should be in a differential diagnosis list of chronic wrist pain even though it is extremely rare.

Intra-articular synovial sarcoma in the ankle joint: A case report.

Intra-articular primary soft tissue sarcomas are extremely rare. The present case report describes a case of intra-articular synovial sarcoma of the ankle joint. A 51-year-old man presented with complaints of swelling and progressive pain in the right ankle. Lateral radiographs of the ankle revealed lytic invasion of the anterior and posterior parts of the talus. Computed tomography imaging revealed a low-density lesion with calcifications around the ankle joint. Magnetic resonance imaging revealed that the diffuse lesion was isointense on T1-weighted images and hypointense to hyperintense on T2-weighted images. The final diagnosis was synovial sarcoma. The foot could not be salvaged as the sarcoma was diffusely spread throughout the ankle joint; thus, the patient underwent below-the-knee amputation with neoadjuvant and adjuvant chemotherapy. He succumbed from fatal arrhythmia 2 years following the initial diagnosis. Although intra-articular primary soft tissue sarcomas are extremely rare, the possibility of malignancy should be considered.

Primary Intra-Articular Synovial Sarcoma of the Knee: A Report of Two Cases and Review of the Literature

Primary Intra-Articular Synovial Sarcoma of the Knee: A Report of Two Cases and Review of the Literature

Synovialosarcome du genou évoquant une pathologie méniscale latérale. À propos d’un cas

Synovial sarcoma (SS) is a rare mesenchymal tumor, accounting less than 10 % of soft tissue sarcomas. We report a case of intra-articular SS mimicking nodular synovitis and lateral meniscus rupture. Due to clinical and radiological presentation, arthroscopic synovectomy was performed, and histology confirmed nodular synovitis. After four years the lesion recurred and new arthroscopic biopsy was performed, revealing a monophasic SS with SYT/SSX1 translocation. Repeated histology of the first specimen confirmed appearance of a nodular synovitis microscopically, with no morphological criteria for a sarcoma, but molecular analysis showed positive SYT/SSX1 translocation. Wide extra-articular knee resection and reconstruction with a tumor megaendoprosthesis-allograft composite was performed with a negative tumor margins. This case report showed that in a case of benign histological appearance, underlying sarcoma is possible and could be identified in early stages only with an advanced pathology methods. Level of evidenceLevel IV historical case.

Intra-Articular Synovial Sarcoma Treated With a Transfemoral Amputation: A Case Report and Review of the Literature

A case of monophasic intra-articular synovial sarcoma in the right knee of a 39-year-old active duty serviceman treated with a transfemoral amputation is presented. The patient was evaluated for right knee pain and fullness. After further workup, the patient underwent computed tomography guided biopsy, with the tissue specimen consistent with intra-articular synovial sarcoma. The patient elected for a transfemoral amputation rather than limb or joint-sparing surgery. The gross specimen measured 3.5 × 3.0 × 1.7 cm in the posteromedial knee. No metastatic lesions were seen on positron emission tomography-computed tomography. Chemotherapy and radiation therapy have not been utilized. The transfemoral amputation adds to the uniqueness of this report and is discussed with a review of the multimodality treatment toward intra-articular synovial sarcoma in prior published literature.

Intra-articular synovial sarcoma

A case of right knee intra-articular synovial sarcoma in a 26-year-old man is reported. The patient had experienced 12 to 18 months of chronic posterior right knee pain with flexion contracture of the leg. Magnetic resonance imaging (MRI) examination demonstrated nonspecific characteristics of a well-circumscribed, homogeneous mass within the posterior lateral compartment of the knee joint. The mass was isointense and hyperintense to muscle on T1- and T2-weighted sequences respectively, and initially clinically diagnosed as a localized tenosynovial giant cell tumor. However, histological examination showed the lesion to be a synovial sarcoma arising from the synovium of the knee joint. Synovial sarcoma may have a nonspecific MR appearance, especially when less than 5 cm in size, often simulating a less aggressive process. Primary intra-articular origin may predispose to earlier presentation, and therefore, radiological evaluation of smaller masses. Nonspecific MR characteristics of small, intra-articular masses provide a diagnostic dilemma. Synovial sarcoma should be considered in the differential diagnosis when distinguishing MR characteristics of other common joint-centered entities are not present.

MR findings of synovial disease in children and young adults: Part 2

Synovium is the thin membranous lining of a joint. It produces synovial fluid, which lubricates and nourishes the cartilage and bone in the joint capsule. Synovial diseases in children can be classified as normal structures as potential sources of pathology (synovial folds: plicae, infrapatellar fat pad clefts), noninfectious synovial proliferation (juvenile idiopathic arthritis, hemophilic arthropathy, lipoma arborescens, synovial osteochondromatosis, pigmented villonodular synovitis, reactive synovitis), infectious synovial proliferation (pyogenic arthritis, tuberculous arthritis), deposition disease (gouty arthropathy), vascular malformation, malignancy (metastasis) and intra-/periarticular cysts and cyst-like structures. Other intra-articular neoplasms, such as intra-articular synovial sarcoma, can mimic synovial disease in children.

Intra articular synovial sarcoma

Synovial sarcoma is a soft tissue neoplasm with a characteristic biphasic pattern. Incidence in soft tissues is 5-10%. Intra articularly synovial sarcoma is extremely rare. Fewer than 5% of all synovial sarcomas arise within the joint space. We report a case of intra articular synovial sarcoma in a young male who presented as internal derangement of the knee.

Magnetic Resonance Appearance of Intra-Articular Synovial Sarcoma

Intra-articular synovial sarcoma is extremely rare. The authors report the magnetic resonance appearance of 2 cases of intra-articular synovial sarcoma and review the current medical literature on this subject. Intra-articular synovial sarcoma must be considered in the differential diagnosis of a heterogeneously enhancing multiloculated intra-articular mass, especially in the knee joint, that does not have the typical radiological features of either synovial osteochondromatosis, pigmented villonodular synovitis, or synovial hemangiomas.