Treatment In Observation Group Research Articles

A Real-World Retrospective Study to Evaluate the Reliability of Cetuximab plus Capecitabine versus Capecitabine as Maintenance Therapy in Patients with RAS and BRAF Wild-Type Metastatic Colorectal Cancer

Background: The optimal maintenance therapy for rat sarcoma (RAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) metastatic colorectal cancers (mCRCs) remains unclear. It is critical to evaluate the reliability of cetuximab-capecitabine (the observation group) relative to capecitabine alone (control group). Patients and Methods: In this retrospective analysis, patients with RAS and BRAF mCRC admitted to Huizhou Municipal Central Hospital, between January 2016 and October 2020 were enrolled and treated with cetuximab plus 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as an initial therapy. Patients whose disease was controlled after at least six cycles of treatment were administered a maintenance therapy until disease progression. We also analyzed the prognosis of patients according to clinicopathological features. Altogether, 39 RAS and BRAF mCRC patients were recruited from January 2016 to October 2020, with 18 cases in the treatment group and 21 cases in the control group. The difference in baseline clinicopathological features between the two treatments is not obvious. Results: The median progression-free survival after maintenance treatment in observation group (9.5 months [95% confidence interval (CI) = 6.4–12.6]), was significantly better than the control group (7.3 months [95% CI = 5.8–8.8]). During maintenance treatment, there were no deaths caused by treatment-related adverse events, and the overall incidence of rash acne was different between the observation and control groups (p < 0.05). Most adverse events were mild and easily controlled. Primary tumor site, baseline carcinoembryonic antigen levels, and microsatellite instability status were independent prognostic factors. Conclusion: Maintenance therapy using cetuximab plus capecitabine improved survival in patients with mCRC and was well tolerated by patients.

Effect of Bushen Chushi() decoction combined with platelet-rich plasma on regulating TGF-β1 and Smad-1 expression in serum of knee osteoarthritis patient

To investigate the effect of Bushen Chushi decoction combined with platelet-rich plasma(PRP) to treat knee osteoarthritis(KOA) in early and middle stage and its regulation on TGF-β1 and Smad-1 expression in serum. Total of 45 patients with KOA in early and middle stage from May 2020 to April 2022 were treated and divided into control group and observation group. In control group, there were 30 patients including 12 males and 18 females, aged from 43 to 69 years old with an average of(57.3±6.5) years old and disease duration ranged from 1.5 to 5.0 years with an average of(3.8±1.7) years, and there were 8 cases in gradeⅠ, 13 cases in gradeⅡ, and 9 cases in grade Ⅲ according to Kellgren-Lawrence Grade, PRP 5 ml was injected into knee joint on the first day of No1, 3 week together for 2 times. In the observation group, there were 15 cases including 7 males and 8 females, aged from 45 to 70 years old with an average of (56.7±6.2) years old and disease duration ranged from 1.8 to 5.7 years with an average of (4.0±1.8) years, there were 4 cases in gradeⅠ, 9 cases in gradeⅡand 4 cases in grade Ⅲ according to the Kellgren-Lawrence Grade, PRP 5 ml were injected into knee joints that the time and frequency were the same as those in the control group, and at the same time Bushen Chushi decoction orally were taken 1 dose per day with a total of 28 doses. All patients were treated for four weeks. Visual analogue scale(VAS) and Lequesne MG score before and after treatment were used to evaluate improvement of knee pain and joint function. The TGF-β1 and Smad-1 levels in serum were measured before and after treatment in two groups. The incidence of complications in two groups was observed. All patients were followed up for 26 to 30 days with an average of (28.0±0.6) days. There was no significant difference in VAS and knee Lequesne MG scores between two groups before treatment(P>0.05). The scores of VAS and knee Lequesne MG on the first day after treatment in both groups were lower than those before treatment(P<0.05). The VAS and knee Lequesne MG scores in observation group were lower than those in control group(P<0.05) on the first day after treatment. The TGF-β1 level in serum after treatment were higher significantly than that before treatment in two groups(P<0.05). After treatment, TGF-β1 level in serum in observation group were lower than those in control group with statistically significant differences(P<0.05). The Smad-1 levels in serum after treatment in observation group were higher significantly than that in control group(P<0.05). The levels of Smad-1 were not statistically significant between before and after treatment(P>0.05). There was no significant difference in postopertaive complications between two groups (P>0.05). The efficacy of Bushen Chushi decoction combined with PRP in treatment of early and middle KOA is better than that of PRP injection alone. The combined treatment could reduce TGF-β1 level and increase Smad-1 level in serum, which may be a mechanism to inhibit inflammation and alleviate cartilage degeneration to some extent.

Effects of Modified Sang ju-Yin Decoction Combined with IFNαlb Nebulization on IL-1β and HBD2 in Children with Asthmatic Bronchitis.

Background Breathing disease swelling of the lung tubes caused by viral infection is more and more likely to develop into related to the lung tubes breathing disease, especially repeating breathing loudly. Objective To investigate the effect of modified Sang ju-Yin Decoction combined with Interferon (IFN)αlb nebulization on children with asthmatic bronchitis and the effects of IL-1β and β-defensin 2 (HBD2). Materials and Methods The clinical data of 80 children with asthmatic bronchitis who were diagnosed and treated in our hospital from May 2019 to May 2021 were selected as the research objects and divided into the control group and the observation group with 40 cases in each group according to different treatment methods. Among them, the control group was nebulized with IFNαlb, and the observation group was given addition and subtraction of Sang ju-Yin Decoction based on the control group. The clinical symptoms, pulmonary function indexes, adverse reactions, and effects on serum inflammatory indexes were observed and compared between the two groups. Results There was no significant difference in the scores of symptoms and signs between the two groups before treatment (P > 0.05), while the scores of shortness of breath, cough, stridor, lung rales, and signs after treatment of observation group were better than those of the control group (P < 0.05). There was no significant difference in serum inflammatory indexes and pulmonary function indexes between the two groups before treatment (P > 0.05), while the differences in IL-6, IL-10, TNF-α, IL-1β, and HBD2 after treatment were significant between the two groups (P < 0.05). After treatment, the RR, TV, and PEF indexes of the two groups of children were significantly improved (P < 0.05). After treatment, the adverse reaction rate of liver function damage, dry throat discomfort, rash, nausea, and vomiting in the observation group was 7.5%, which was significantly lower than 27.5% in the control group (P < 0.05). Conclusion Modified Sang ju-Yin Decoction combined with IFNαlb nebulization can improve symptoms and promote the recovery of patients in the treatment of acute bronchitis.

Effects of S-adenosyl-L-Methionine Combined with Ursodesoxycholic Acid on Serum Endotoxin, MMP-9 and IL-18 in Neonates with Cholestasis.

To compare the effect of ursodesoxycholic acid (UDCA) with S-adenosyl-L-methionine (SAMe) plus UDCA in handling of cholestasis in neonates, and their influences on serum endotoxin, matrix metalloproteinase-9 (MMP-9) and interleukin 18 (IL-18). Randomised controlled trial. Luzhou People's Hospital, China, from April 2019 to December 2020. A total of 102 neonates with cholestasis were evenly divided into control group and observation group with random double-blind. The former treated with UDCA tablets, and the latter was treated with SAMe plus UDCA. Serum endotoxin, MMP-9 and IL-18 were compared between the two groups. Total effective rate of treatment in observation group was 92.16% (47 cases), which was higher than that in control group 70.59% (36 cases) (p=0.005). Levels of serum endotoxin, MMP-9 and IL-18 in observation group were respectively 11.12 ± 1.07 pg/mL, 646.72 ± 42.56 ng/mL and 2.51 ± 0.19 pg/mL, which was lower than those in control group (p<0.001, p =0.007 and p<0.001, respectively) after 10 days of treatment. Compared with UDCA alone, SAMe plus UDCA can more effectively improve the curative effect of neonatal cholestasis, and reduce serum endotoxin, MMP-9 and IL-18 levels. Key Words: Ursodesoxycholic acid (UDCA), Neonates, Cholestasis, Endotoxin, Matrix metalloproteinase-9 (MMP-9), Interleukin 18 (IL-18).

Salbutamol combined with budesonide in treatment of pediatric bronchial asthma and its effect on eosinophils

BACKGROUND The aim of this study was to investigate and discuss the salbutamol combined with budesonide in treatment of pediatric bronchial asthma (BA) and its effect on eosinophils (EOS). METHODS Ninety-eight BA children admitted and treated in our hospital from July 2016 to June 2017 were collected and divided into control group (N.=49) and observation group (N.=49) according to random number table. The children in control group were treated with budesonide and those in observation group were treated with salbutamol combined with budesonide. The clinical efficacy, pulmonary functions and levels of T-lymphocyte subsets (including cluster of differentiation 3 (CD3)+, CD4+, CD8+ and CD4+/CD8+) in the immune system between two groups were compared after the treatment; the levels of eosinophil cationic protein (ECP) and eotaxin in the children were compared before the treatment and at 1, 4 and 8 weeks after the treatment; the changes in EOS counts in blood and induced sputum of the children before and after the treatment were compared, and the EOS apoptosis rate was compared at 1, 4 and 8 weeks after the treatment. RESULTS The effective rate of treatment in observation group was significantly higher than that in control group (P<0.05). After the treatment, the indexes of pulmonary function in observation group were obviously better than those in control group (P<0.05). Compared with those in control group, the levels of CD3+, CD4+ and CD4+/CD8+ of the children in observation group were elevated remarkably, while the CD8+ level was lowered (P<0.05). The levels of ECP and eotaxin in the two groups were decreased after the treatment compared with those before the treatment, and the levels in observation group were superior to those in control group (P<0.05). After the treatment, the EOS counts of both groups of children were lower than those before the treatment, and the decrease in observation group was more notable than that in control group. At 1, 4 and 8 weeks after the treatment, the EOS apoptosis rate in observation group was obviously higher than that in control group (P<0.05). CONCLUSIONS The treatment of salbutamol combined with budesonide for pediatric BA has significant therapeutic effects; it can restore the pulmonary functions rapidly and improve the immunity of the lung, reduce the levels of eotaxin, ECP and EOS of the child patients and promote EOS apoptosis.

Cupping treatment combined with antibiotics for bacterial pneumonia in children: a randomized controlled trial

To compare the clinical efficacy of cupping treatment combined with antibiotics and antibiotics alone for bacterial pneumonia in children. A total of 72 children with bacterial pneumonia were randomly divided into an observation group (36 cases, 1 case dropped off) and a control group (36 cases). The children in the control group were treated with intravenous drip of cefodizine sodium [80 mg/(kg•d)] for 7 days. Based on the treatment of the control group, the children in the observation group were treated with cupping treatment on the bladder meridian of the back on the first day and the fourth day of antibiotic treatment; each cupping treatment was given for 5-10 min; the treatment of observation group was given for 7 days. The days for complete fever reduction, TCM syndrome scores and Canadian acute respiratory illness flu scale (CARIFS) scores before and after treatment were observed, and the clinical efficacy was evaluated. The days for complete fever reduction in the observation group were shorter than that in the control group (P<0.05). After treatment, the TCM syndrome scores and CARIFS scores in the two groups were reduced (P<0.05), and the cough score, expectoration score, lung auscultation score of TCM syndrome and cough score, runny nose score and sore throat score of CARIFS in the observation group were lower than those in the control group (P<0.05). The cured rate in the observation group was 97.1% (34/35), which had no significant difference with 91.7% (33/36) in the control group (P>0.05). Cupping treatment combined with antibiotics has similar efficacy with antibiotics alone for bacterial pneumonia in children, but shows better effect in shortening the duration of fever and improving pulmonary symptoms.

Effects of nimodipine combined with betahistine on CRP and other inflammatory cytokines and vascular endothelial function in patients with hypertensive cerebral vasospasm.

This study aims to investigate the effect of nimodipine combined with betahistine on the levels of CRP and other inflammatory cytokines, as well as vascular endothelial function in patients with hypertensive cerebral vasospasm. A total of 80 patients with hypertensive cerebral vasospasm from March 2016 to September 2018 were enrolled and randomly equally divided into two groups. At 1 week before enrollment, the application of all antihypertensive drugs was stopped. Then amlodipine tablets were used in control group, based on which nimodipine tablets were applied in observation group. All the patients included were followed up for 1 month. The changes in the cerebral vasospasm index in the course of treatment as well as inflammatory cytokines and indicators related to vascular endothelial function at 1 month after treatment were measured and compared between the two groups. The correlations of the cerebral vasospasm index with the changes in inflammatory cytokines and vascular endothelial function-related factors in the body were analyzed. Finally, the effective rates of blood pressure regulation and cerebral vasospasm treatment were compared, while the adverse reactions and the overall clinical treatment effect of the two groups were evaluated. The cerebral vasospasm indexes in observation group were significantly lower than those in control group at 3 d, 1 week and 1 month after treatment (p < 0.05). At 1 month after treatment, the levels of inflammatory cytokines such as high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in observation group were significantly reduced compared to those in control group (p < 0.05). As for vascular endothelial function-related indicators, the endothelin-1 (ET-1) level in observation group was markedly lower than that in control group, whereas the level of nitric oxide (NO) was statistically higher than that in control group (p < 0.05). The cerebral vasospasm index was statistically positively correlated with changes in hs-CRP, IL-6, TNF-α and ET-1 (p < 0.05), but negatively correlated with changes in NO (p < 0.05). Besides, the effective rates of blood pressure regulation and cerebral vasospasm treatment in observation group were significantly higher than those in control group (p < 0.05). The overall treatment effective rate in observation group was markedly higher than that in control group (p < 0.05), and there were no significant differences of adverse reactions between the two groups (p > 0.05). For the treatment of hypertensive cerebral vasospasm, combined application of betahistine on the basis of nimodipine can effectively reduce the body's aseptic inflammatory responses, improve vascular endothelial function and increase the cerebral circulation blood flow, which offers a favorable strategy for clinical therapy.

Efficacy of Periodontal Tissue Regeneration Combined with Orthodontic Therapy on Periodontitis and Its Influences on Inflammatory Factors in Patients

Objective: To assess the effect of periodontal tissue regeneration combined with orthodontic treatment on periodontitis and inflammatory factors. Methods : 100 patients with periodontitis were randomly separated into observation group and control group. Patients were treated with periodontal tissue regeneration in control group and received orthodontic treatment in observation group. The periodontal indexes, X-ray cephalometric indexes, serum inflammatory factor levels, tooth mobility, the postoperative complications, efficacy and life quality were measured. Results: After treatment, levels of clinical attachment loss (CAL), probing depth (PD), sulcus bleeding index (SBI), gingival index (GI), plaque index (PLI), SNB angle, SNA angle, IL-8, IL-5, TNF-α and hs-CRP of patients in observation group were significantly decreased, while ANB angle was significantly elevated (p &lt; 0 05). Meanwhile, the treatment effective rate and quality of life score was significantly improved after treatment in observation group (p &lt; 0 05). Conclusion: Periodontal tissue regeneration combined with orthodontic treatment can significantly improve periodontitis symptoms, promote the recovery of tooth function, reduce inflammation and postoperative complications, and improve the uniformity and appearance of teeth in patients with periodontitis.

External physical vibration lithecbole in treatment of ureteral calculi with renal colic used different positions: a prospective multicenter randomized controlled clinical study

Objective To evaluate the efficacy and safety of different positions external physical vibration lithecbole (EPVL) therapy for ureteral calculi related renal colic. Methods This study was a prospective multicenter randomized controlled trial. The inclusion criteria was that patients volunteered to participate in the trial and signed informed consent, patients’age ranged from 18-65 years old, ureteral calculi related with renal colic, stone diameter was less than 7 mm, patients were not treated with analgesia, antispasmodic drugs. The exclusion criteria was that combination of severe urinary tract infection, severe hydronephrosis, urinary malformation, severe hypertension, history of cerebrovascular disease, vital organ dysfunction, obesity (BMI>35 kg/m2), history of ureteral calculi exceeded 2 months, abnormal blood coagulation. Patients were randomized into observation group and control group using random number table method. The observation group and the control group were placed on the physical vibration stone arranging machine with low foot high and high foot low respectively. The inclination angle was 24°. The secondary vibrator vibrated for 6 minutes, then the patient took the prone and opened the main, the secondary vibrator. The treatment is completed after 6 minutes of vibration. The analgesic effect, stone removal, follow-up effects and adverse reactions in the two groups was compared. We defined the pain relief rate as(VAS score before treatment-VAS score after treatment)/VAS score before treatment×100%. Results A total of 100 patients were included in the study, 50 in the observation group and 50 in the control group. There were no statistical difference in the age of the two groups [(41.8±11.7)years and (46.6±13.9 years)], gender distribution [37(male)/13(female) and 42(male)/ 8(female)], location of stones (in the observation group, 19 cases in upper ureter, 7 cases in the middle ureter and 24 cases in the lower ureter; in the control group, 12 cases in the upper ureter, 3 cases in the middle ureter, and 35 in the lower ureter), left and right distribution of stones [21(right)/ 29 (left) and 22 (right)/ 28(left)], long diameter of stones [(5.2±0.9)mm and(5.1±1.1)mm], VAS scores before treatment (7.5±1.4 and 7.6±1.5), and readmission rate [22%(11/50)With 18%(9/50)], 1 week stone removal rate [70%(35/50) and 64%(32/50)]. The incidence of adverse reactions was 8%(4/50) in the observation group including 3 cases of nausea, 1 case of vomiting. The incidence of adverse reactions was 4% in the control group (2/50), which 2 cases showed nausea. The number of patients who chose EPVL, ESWL or surgery for the subsequent treatment in observation group was 35 cases, 9 cases, and 6 cases respectively. The number of patients who chose EPVL, ESWL or surgery for the subsequent treatment in the control group was 35 cases, 10 cases and 5 cases respectively. There was no significant difference between the two groups (P>0.05). The VAS score after treatment of the observation group was lower than that of the control group (2.4±1.3 and 3.7±1.5, P<0.01). The total effective rate of the observation group was higher than that of the control group [94%(47/50) and 76%(38/50), P<0.01]. 46 patients underwent urinary ultrasonography to check the degree of hydronephrosis. The reduction rate of hydronephrosis was higher in the observation group than in the control group [54.5%(18/33) and 30.8%(4/13)], but there was no significant difference between the two groups (P=0.146). In the upper ureteral calculi, the VAS score of the observation group was lower than that of the control group (2.4±0.3 and 3.9±0.4, P<0.01). There was no significant difference in the total effective rate between the two groups. In the lower ureteral calculi, the observation group had low VAS score after treatment. In the control group (2.4±0.2 and 3.5±0.2, P<0.01), there was no significant difference in the total effective rate between the two groups; the middle segment stones were less included (10 in total) and were not discussed. Conclusions The external physical vibration lithecbole adopts high and low position has better effect than head low foot high position in treatment of ureteral calculi with renal colic, and security is acceptable. Key words: Ureteral calculus; Renal colic; Posture; Randomized control research; Multiple center

Application of tertiary hospital and community health integrated management model in foot care of patients with diabetes mellitus

Objective To analyze the application value of tertiary hospital and community health integrated management model in the foot care of diabetic patients. Methods A total of 180 cases of patients with diabetes mellitus admitted to the First Affiliated Hospital of Henan University from January 2018 to June 2018 were selected for the study and were divided into observation group and control group according to the random number table method, with 90 cases in each group.Control group was given routine management, and observation group adopted tertiary hospital and community health integrated management model, and they were intervened for 6 months.The episode frequency, hospitalization frequency, hospital stay, hospitalization expenses, and fasting blood glucose(FBG), postprandial 2 h blood glucose(P2BG) and glycosylated hemoglobin(HbA1c), foot care effects [Chinese version of Nottingham assessment of functional foot-care(CNAFF)], self-management ability scale(SDSCA) score, diabetes specific quality of life scale(DSQL) score before and after intervention were recorded in the two groups. Results The episode frequency, hospitalization frequency, hospital stay and hospitalization expenses in observation group were lower than those in control group.The FBG, P2BG, and HbA1c in observation group after intervention were lower than those in control group, and the differences were statistically significant(P<0.05). The good foot care rate at 6 months after intervention in observation group was higher than that in control group, and the difference was statistically significant(P<0.05). The SDSCA scores in observation group were higher than those in control group at 1 month, 3 months and 6 months after intervention, while the DSQL score was lower than that in control group, and the differences were statistically significant(P<0.05). Conclusions Tertiary hospital and community health integrated management model for patients with diabetes mellitus, and it can significantly improve the blood glucose level, improve the quality of foot care, quality of life and self-management ability.Therefore it is worthy of clinical promotion and practice. Key words: Community health; Integrated management model; Diabetes mellitus; Foot nursing

Effects of emotional release therapy on social psychological adaptability and self-consistency and congruence among elderly patients with coronary disease

Objective To explore the effects of emotional release therapy on social psychological adaptability and self-consistency and congruence among elderly patients with coronary disease. Methods From March 2015 to March 2017, we selected 148 elderly patients with coronary disease of Department of Cardiology at Yaan People's Hospital of Sichuan Province by convenience sampling. All of the patients were divided into observation group and control group according to hospital admission sequence, 74 cases in each group. Control group received routine nursing and health education in Department of Cardiology. On the basis of that in control group, observation group carried out emotional release therapy. The intervention of two groups all lasted for four weeks. Before and after intervention, the social psychological adaptability and self-consistency and congruence were all evaluated with the Ostomy Adjustment Inventory (OAI) and Self-Consistency and Congruence Scale (SCCS) . Results After intervention, the total score and scores of OAI of two groups were all higher than those before intervention and those of observation group higher than those of control group (P<0.01) . After intervention, the scores of two dimensions (disharmony between oneself and experience, self-stiffness) reduced compared with those before intervention in observation group, along with being lower than those in control group; besides, the score of self-flexibility increased in observation group higher than that in control group with significant differences (P<0.05) . Conclusions Emotional release therapy can improve social psychological adaptability and self-consistency and congruence among elderly patients with coronary disease. Key words: Aged; Coronary disease; Emotional release therapy; Social psychological adaptability; Self-consistency and congruence

Clinical effects of tanshinone ⅡA sodium sulfonate combined with trimetazidine and levocarnitine in the treatment of AVMC and its effects on serum TNF‑α, IL‑18 and IL‑35

Clinical effects of tanshinone IIA sodium sulfonate combined with trimetazidine and levocarnitine in the treatment of acute viral myocarditis (AVMC) were investigated. Eighty-six patients with AVMC treated in Dongying City People's Hospital from August 2016 to July 2017 were selected and randomly divided into control group (n=43) and observation group (n=43). Patients in control group were treated with tanshinone IIA sodium sulfonate, while those in observation group were treated with trimetazidine and levocarnitine. The curative effect and improvement in clinical symptoms were compared between the two groups of patients, and enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of heart-type fatty acid-binding protein (H-FABP), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) in patients after treatment. Besides, the changes in levels of serum tumor necrosis factor-α (TNF-α), interleukin (IL)-18 and IL-35 were detected via ELISA. The total effective rate of treatment in observation group was significantly higher than that in control group (p<0.05). The improvement in clinical symptoms in observation group was significantly superior to that in control group (p<0.05). After treatment, levels of H-FABP, CK-MB and cTnI in observation group were obviously lower than those in control group (p<0.05). At 3, 5 and 7 days after treatment, the levels of TNF-α and IL-18 in both groups of patients were decreased compared with those before treatment, but the level of IL-35 was increased compared with that before treatment, and changes in observation group were more significant than those in control group (p<0.05). Tanshinone IIA sodium sulfonate combined with trimetazidine and levocarnitine has definite curative effects in the treatment of patients with AVMC, which can alleviate myocardial injury with higher safety, and effectively mitigate the inflammatory response in patients, so it is of great clinical significance.

Influence of rosuvastatin combined with noninvasive positive pressure ventilation on pulmonary ventilation function, SGRQ score and laboratory parameters of patients with AECOPD

Objective To investigate the influence of rosuvastatin combined with noninvasive positive pressure ventilation on pulmonary ventilation function, SGRQ score and laboratory parameters of patients with AECOPD. Methods 110 patients with AECOPD were chosen and they were randomly divided into two groups according to the digital table, each group in 55cases.The control group received noninvasive positive pressure ventilation, and the observation group received rosuvastatin on the basis of the control group.The number of acute exacerbation and re-hospitalization, pulmonary ventilation function, SGRQ score, 6MWT, the levels of IL-8, CRP, alanine aminotransferase, triacylglycerol and total cholesterol before and after treatment of the two groups were compared. Results The number of acute exacerbation and re-hospitalization of the observation group were significantly lower than those of the control group(t=3.19, 2.84, all P<0.05). The levels of FEV1 and FEV1/FVC after treatment of both two groups were significantly higher than before treatment(t=2.88, 3.14, 2.90, 3.42, all P<0.05). The levels of FEV1 and FEV1/ FVC after treatment of the observation group were significantly higher than those of the control group(t=2.38, 2.61, all P<0.05). The SGRQ scores and 6MWT after treatment of both two groups were significantly better than those before treatment(t=2.59, 2.51, 2.84, 3.17, all P<0.05). The SGRQ scores and 6MWT after treatment of observation group were significantly better than those of the control group (t=2.59, 2.51, all P<0.05). The levels of the IL-8, CRP, alanine aminotransferase, triacylglycerol and total cholesterol after treatment of both two groups were significantly lower than those before treatment (t=2.78, 2.50, 2.94, 3.07, 4.26, 3.89, 3.02.3.67, all P<0.05). The levels of IL-8, CRP, alanine aminotransferase, triacylglycerol and total cholesterol after treatment of the observation group were significantly lower than those of the control group(t=2.64, 2.33, 2.81, 3.15, all P<0.05). Conclusion Rosuvastatin combined with noninvasive positive pressure ventilation in the treatment of patients with AECOPD can efficiently promote lung function recovery, higher quality of life and exercise endurance, improve the laboratory indicators and is help to avoid the acute attack and re-hospitalization for long-term. Key words: Pulmonary disease, chronic obstructive; Intermittent positive-pressure ventilation; Rosuvastatin

Effects of CICARE communication model combined with WeChat health education on self-management among patients with type 2 diabetes mellitus combined with pulmonary tuberculosis

Objective To explore the effects of CICARE communication model combined with WeChat health education on self-management capacity, focal absorption and indexes of glucose metabolism among patients with type 2 diabetes mellitus (T2DM) combined with pulmonary tuberculosis (PTB) . Methods A total of 80 patients with T2DM combined with PTB at Chest Hospital of Xinjiang Uyghur Autonomous Region were selected by convenience sampling from 1st January 2016 to 31st December 2016. They were divided into control group (n=40) and observation group (n=40) with the method of the random number table. Patients in control group received conventional nursing and health education during hospitalization and at discharge. On the basis of control group, patients in observation group received nursing with the CICARE communication model along with health education by WeChat after discharge. The self-management capacity, focal absorption and effective rate, index of glucose metabolism of patients of both groups were compared six months after intervention. Results Before intervention, there were no statistically significant differences in self-management capacity and index of glucose metabolism (P>0.05) . Six months after intervention, the score of self-management capacity and effective rate of treatment in observation group was higher than those in control group. Besides, the fasting plasma glucose (FPG) , 2-hour postprandial blood glucose (2hPG) and glycosylated hemoglobin in observation group were lower than those in control group with significant differences (P<0.05) . Conclusions The CICARE communication model combined with the communication and propagation function of WeChat can improve the self-management and clinical symptoms. Moreover, it has a synergistic action in improving treatment effects. Key words: Diabetes mellitus, type 2; Tuberculosis; CICARE communication model; WeChat health education; Self care

Rehabilitation effect of trunk control training under suspension on motor function of stroke patients in sequela period

Objective To study the effect of two trunk control trainings on motor function recovery of stroke patients in sequela period. Methods A total of 42 patients were randomly divided into control group (N = 21) and observation group (N = 21). The control group was treated by traditional trunk control training, and the observation group was treated by trunk control training using suspension technology. Both groups all received other conventional rehabilitation treatment. All patients received Trunk Control Test (TCT), Functional Ambulation Category Scale (FAC), Berg Balance Scale (BBS) and 10 m Maximum Walking Speed (10 m MWS) before and 20 d after treatment. Results After two courses of treatment, the scores of TCT ( P = 0.000), FAC ( P = 0.000), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) were significantly improved in both groups. The scores of TCT ( P = 0.000), FAC ( P = 0.002), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) after treatment in observation group were all significantly higher than those in control group. Conclusions The method of trunk control training under suspension can effectively improve the motor function of stroke patients in sequela period. DOI: 10.3969/j.issn.1672-6731.2017.04.006

Application of nursing case management mode framed by Omaha system in patients with hepatocirrhosis complicated with gastrointestinal bleeding

Objective To explore the application of nursing case management mode framed by Omaha system in patients with hepatocirrhosis complicated with gastrointestinal bleeding, so as to provide evidence-based basis for clinical nursing. Methods A total of 72 hepatocirrhosis complicated with gastrointestinal bleeding patients were collected from July 2014 to July 2016 in our hospital. All the patients were randomized divided into observation group (36 cases) and experimental group (36 cases). The patients of observation group were given case management mode framed by Omaha system, while the patients of control group were given conventional case management model. Analysis and evaluation of scores were implemented before and after the nursing intervention in observation group. The quality of life, hospitalization days and number of hospitalizations after discharge were compared between two groups. Results The nursing problems of observation group during hospitalization were mainly distributed in the environment, social psychology, physiology and health related behaviors. After nursing intervention, there were significant differences in all nursing outcomes for nursing problems (t=12.470, 10.720, 17.520, 7.600, 7.549, 12.146, 16.857, 5.607, 14.683, 7.085, 11.66, 11.024, 12.723; P<0.05) . After intervention in observation group, the activity of daily living was (19.18±5.67), social activity (13.96±3.89), depression symptom (11.69±3.97), anxiety symptom (9.34±2.88), and survival quality (54.17±5.45), which were less than (27.21±3.84) , (18.53±3.58) , (17.64±2.75) , (15.72±2.93) , (79.10±8.63) (t=7.036, 5.187, 7.392, 9.317, 14.654; P<0.05). After intervention, the length of hospitalization was (8.7±3.9) d, the cost (5 419.5±2 539.2)Yuan and the revisit times (0.4±0.2), which were less than (10.8±3.4)d, (7 312.4±4 280.1)Yuan and (0.7±0.3) of control group (t=2.435, 2.282, 4.992; P<0.05). Conclusions Compared with conventional methods, the case management framed by Omaha system can effectively improve the quality of life, reduce hospitalization days, hospitalization cost and number of re-hospitalizations after discharge. Key words: Liver cirrhosis; Omaha system; Case management; Gastrointestinal bleeding

Effect of motor relearning programme on motor function recovery of acute stroke patients with hemiplegia

Objective To explore the effect of motor relearning programme (MRP) on motor function recovery of patients with hemiplegia after acute stroke. Methods A total of 64 hemiplegic patients with acute stroke (duration ≤ 14 d) were randomly divided into 2 groups: control group (N = 32) and observation group (N = 32). Control group received routine drug therapy and conventional rehabilitation training, and observation group was treated by routine therapy and MRP training. Fugl-Meyer Assessment Scale - Balance (FMA - Balance), Modified Rivermead Mobility Index (MRMI) and modified Barthel Index (mBI) were used to assess the motor function of patients in both groups before and after treatment. Results All patients successfully completed the rehabilitation training without severe adverse events. A few patients felt fatigue occasionally after training and recovered after rest. Compared to before treatment, the FMA-Balance score ( P = 0.000), MRMI score ( P = 0.000) and mBI score ( P = 0.000) after treatment in both groups were significantly increased. Compared to control group, the FMA-Balance score ( P = 0.031), MRMI score ( P = 0.013) and mBI score ( P = 0.049) after treatment in observation group were significantly increased. Conclusions MRP training in the early stage of stroke is beneficial to the recovery of motor function of patients. DOI: 10.3969/j.issn.1672-6731.2017.03.007

Effects of human chorionic gonadotropin combined with clomiphene on Serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome.

ObjectiveEffects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome were analyzed.Methods90 patients with polycystic ovarian syndrome treated from January 2015 to March 2016 were randomly and evenly divided into control group and observation group. Patients in the control group were only treated with clomiphene. On the basis of the treatment in control group, human chorionic gonadotropin was added in the treatment of observation group. The changes of E2, FSH, LH, PRL levels were compared between two groups before and after the treatment. Clinical curative effects of patients in the two groups was evaluated. Adverse reactions during treatment in two groups were observed and recorded. The incidence of adverse reactions was calculated.ResultsSerum E2, FSH, LH and PRL levels in the two groups decreased significantly after treatment compared with that before treatment. The difference is statistical significant (P < 0.05). After the treatment, E2, FSH, LH and PRL levels in the observation group were lower than that in the control group and the difference is statistical significant (P < 0.05). Total effective rate was 64.44% in the control group and 93.33% in the observation group. There were statistically significant difference in clinical curative effects in the two groups (P < 0.05). Different degrees of adverse reactions were found in both groups during treatment, such as nausea, vomiting, anorexia, liver dysfunction. There were 2 cases of nausea, 2 cases of vomiting, 3 cases of anorexia and 1 case of liver dysfunction from the 45 patients in control group. The total incidence of adverse reactions was 17.78% (8/45). There were 1 case of nausea, 1 case of vomiting, 1 case of anorexia and no liver dysfunction from the 45 patients in observation group. The total incidence of adverse reactions was 6.67% (3/45). The total incidence of adverse reactions in the observation group was significantly higher than that in the control group and the difference was not statistically significant (P > 0.05).ConclusionCombined use of human chorionic gonadotropin can significantly reduce serum E2, FSH, LH and PRL levels, improve clinical curative effects and reduce the incidence of adverse reactions. Human chorionic gonadotropin has high application value on the treatment of polycystic ovary syndrome.

Investigation of the curative effect of chemotherapy combined with DC-CIK cell immunotherapy in metastatic breast carcinoma

Objective To compare the efficacy and adverse reactions of TA regimen (docetaxel + epirubicin) and immunization therapy of TA regimen combined with dendritic cell (DC)-cytokine induced killer cell (CIK) in treating the patients with metastatic breast cancer (MBC). Methods Clinical data of 43 patients with MBC received treatment in our hospital from January 2011 to January 2013 were retrospectively analyzed. Patients included were divided into two groups according to the treatment, simple treatment group (TA regimen, control group, 22 cases) and combined treatment group (TA regimen + DC-CIK cell, observation group, 21 cases). The curative effect, improvement situation of clinical symptoms, adverse reactions and changes of T cell immune phenotype in peripheral blood of patients before and after treatment in the two groups were compared. Results The total efficiency of treatment in observation group (85.7%) was higher than that in control group (63.6%), and the difference was statistical significant (χ2=4.949, P=0.026). Among the incidences of all kinds of adverse reaction appeared during the treatment in two groups, the white blood cells count decreased was the highest in observation group (76.2%) and in control group (59.1%), the difference had no statistical significance (χ2=0.858, P=0.36). After treatment, the rates of fatigue, loss of appetite, insomnia and night sweats of patients in observation group were lower than those in control group (23.8% vs. 54.5%, χ2=4.246, P=0.04; 19.0% vs. 54.5%, χ2=5.795, P=0.02; 19.0% vs. 50.0%, χ2=4.532, P=0.03). The CD3+ (60.4±12.3 vs. 47.4±12.8, t=3.393, P<0.01), CD3+ /CD4+ (41.7±9.6 vs. 28.1±10.5, t=5.442, P<0.01), CD4+ /CD8+ (1.5±0.2 vs. 1.0±0.2, t=8.195, P<0.01), NK cells (27.3±5.9 vs. 15.3±6.1, t=6.643, P<0.01), NK T cells (14.7±1.4 vs. 6.0±1.2, t=11.020, P<0.01) after treatment in observation group were obviously higher than those in control group. Conclusion Comparing with the pure TA scheme, the curative effect of immunization therapy of TA regimen combined with DC-CIK cell in treating the patients with MBC is better. It significantly improves the immune functions of patients with MBC, and does not increase adverse reaction. Key words: Breast neoplasms; Immunotherapy; Antineoplastic combined chemotherapy protocols

Influence of Cinepazide Maleate on Vascular Endothelial Function of Patients with Acute Myocardial Infarction

&lt;strong&gt;Objective&lt;/strong&gt;: To study influence of cinepazide maleate on vascular endothelial function of patients with acute myocardial infarction. &lt;strong&gt;Methods&lt;/strong&gt;: 150 cases of patients with acute myocardial infarction were divided into the observation group and the control group, two groups were treated by conventional therapy about acute myocardial infarction, the observation group added 5%GS250 mL + cinepazide maleate 160 mg IV drip q.d, the control group added 5%GS250 mL IV drip q.d, the treatment course were 3 weeks, changes of vascular endothelial function and the blood serum no level before and after treatment were detected. &lt;strong&gt;Result&lt;/strong&gt;: vascular endothelial function after treatment in observation group were obviously improved than that before treatment (&lt;em&gt;p&lt;/em&gt; = 0.03) , blood serum no level was obviously increased (&lt;em&gt;p&lt;/em&gt; ﹤ 0.05); about 3 weeks after treatment, vascular endothelial function in the observation group was obviously better than that of the control group (&lt;em&gt;p&lt;/em&gt; = 0.04), the blood serum no level of the observation group was obviously higher than that of the control group (&lt;em&gt;p&lt;/em&gt; ﹤ 0.05).&lt;strong&gt; Conclusion&lt;/strong&gt;: Cinepazide maleate remarkably improves vascular endothelial function of patients with acute myocardial infarction.