The interstellar extinction law is important for interpreting observations and inferring the properties of interstellar dust grains. Based on the 993 prism/CLEAR spectra from the James Webb Space Telescope (JWST), we investigate the 0.6–5.3 μm interstellar dust extinction law. We propose a pair method to obtain the reddening curves based only on JWST observed spectra. Most of the high-extinction sources are toward the young star cluster Westerlund 2. The infrared 1.0–5.3 μm reddening curves agree with the power law A λ ∝ λ −α well. We determine an average value of α = 1.98 ± 0.15, which is consistent with the average value of the Galaxy. We find that α may be variable and independent of R V . With the derived α, we convert the reddening curves into the extinction curves and establish the nonparameterized α-dependent extinction curves in the wavelength range of 0.6–5.3 μm. At λ < 1 μm, the derived extinction law is not well described by the parameterized power-law-type curve. Our nonparameterized α-dependent extinction curves are suitable for the extinction correction of JWST-based photometry and spectra measurements at 0.6–5.3 μm. We also provide the extinction coefficients for the JWST NIRCam bandpasses with different α.
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