Soil fertility is a critical factor in agricultural production, directly impacting crop growth, yield, and quality. To achieve precise agricultural management, accurate spatial interpolation of soil parameters is essential. This study developed a new interpolation prediction framework that combines Radial Basis Function (RBF) neural networks with Inverse Distance Weighting (IDW), termed the IDW-RBFNN. This framework initially uses the IDW method to apply preliminary weights based on distance to the data points, which are then used as input for the RBF neural network to form a training dataset. Subsequently, the RBF neural network further trains on these data to refine the interpolation results, achieving more precise spatial data interpolation. We compared the interpolation prediction accuracy of the IDW-RBFNN framework with ordinary Kriging (OK) and RBF methods under three different parameter settings. Ultimately, the IDW-RBFNN demonstrated lower error rates in terms of RMSE and MRE compared to direct RBF interpolation methods when adjusting settings based on different power values, even with a fixed number of data samples. As the sample size decreases, the interpolation accuracy of OK and RBF methods is significantly affected, while the error of IDW-RBFNN remains relatively low. Considering both interpolation accuracy and resource limitations, we recommend using the IDW-RBFNN method (p = 2) with at least 60 samples as the minimum sampling density to ensure high interpolation accuracy under resource constraints. Our method overcomes limitations of existing approaches that use fixed steady-state distance decay parameters, providing an effective tool for soil fertility monitoring in delta regions.