In 2021, the rail freight industry proved its competitiveness despite the restrictions caused by the coronavirus pandemic. In the segment of rail freight transport between Asia and Europe, this was achieved by positive transport results. Container transport in international rail traffic was increased. The railways carried out work on the development and organization of the transport of high-capacity containers in international traffic, including the organization of container block trains in the Eurasian space. The year 2022 has brought about fundamental changes in the perception of safety and the role of rail transport in traffic between Asia and Europe. An unexpected armed conflict caused chaos in trade, production and transport. In the corridors connecting Asia with Europe, problems arose, supply chains were disrupted. The geopolitical situation in Eastern Europe remains tense and unpredictable. This results in lasting consequences for production, supply and demand chains, transport corridors in the Eurasian space. This also applies to rail transport as part of the New Silk Road concept. The aim of this article is to provide a synthetic analysis of the impact of geopolitical changes and the armed conflict in Ukraine on the functioning of the Silk Railroad and transport volumes in rail freight traffic between Asia and Europe. The above analysis was carried out on the basis of research on secondary sources and available source materials obtained from OSJD member countries that participate in rail transport on the Silk Road.