ObjectivesWe conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus.MethodsBoth questionnaires were conducted for one visit to the clinic. Disease activity was evaluated by the SLEDAI-2K, while the chronic damage was assessed by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined according to SLEDAI 2K and SDI.ResultsA total of 400 patients with lupus (F/M 363:37, mean age 34,2±11.5 years, mean disease duration 106,3±91,9.0 months) were included. All patients were divided into 4 groups: SLEDAI 2K ≤4 – 136 pts, SLEDAI-2K ≥4 – 264 pts, SDI =0 – 177 pts, SDI ≥1 – 223 pts.QOL as assessed by SF-36 and LupusQoL was low in all groups of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in Table 1.Table 1.Relationship between disease activity, organ damage and health-related quality of life as assessed by LupusQoL and SF-36 in 400 Russian patients with systemic lupus erythematosusLupusQoLdomainsSLEDAI 2K≤4Mean (SD)SLEDAI 2K ≥4Mean (SD)PSF-36domainsSLEDAI2K ≤4Mean (SD)SLEDAI-2K ≥4Mean (SD)PComparablePhysical health70,1±22,164,9±23,60,07PF65,6±28,260,6±28,50,1Emotional health67,3±24,863,2±24,60,13MH52,2±9,049,6±7,80,001Pain74,7±23,667,5±24,80,007BP46,3±9,547,3±8,40,09Fatigue65,7±24,565,5±24,80,22VT55,5±23,348,3±9,50,007NoncomparablePlanning71,1±27,960,1±28,00,0004SF71,0±24,071,1±24,10,003Intimaterelationships78,3±28,769,9±31,10,003GH55,9±18,755,9±18,70,34Burden to others61,2±26,854,2±28,10.003RE59,3±42,459,3±42,40,012Body image71,1±24,762,2±28,50,007RP65,6±28,265,6±28,20,028LupusQoLdomainsSDI =0 Mean (SD)SDI ≥1 Mean (SD)PSF-36 domainsSDI =0 Mean (SD)SDI ≥1 Mean (SD)PComparablePhysical health71,2±22.563,3±23,10,002PF69,2±27,457,1±28,20,0007Emotional health66,2±25,263,3±24,30,24MH50,31±7,950,6±8,70,6Pain72,3±24,268,2±24,80,03BP47,02±8,446,9±9,10,84Fatigue65,7±25,360,35±24,10,03VT55,6±20,349,5±24,90.02NoncomparablePlanning67,7±27,360,9±29.10.03SF64,05±28,160,5±26,40,21Intimaterelationships76,1±28,470,6±32,50,22GH52,11±20,247,41±20,10.06Burden to others55,7±28,457,4±27,30,68RE56,29±42,146,9±41,80,06Body image66,6±27,964,1±27,30,33RP50,54±42,439,15± 13,10,0001It was shown that the domain of pain of the LupusQoL questionnaire (p<0.007) statistically significantly responds to disease activity in contrast to the comparable SF-36 scale. The domains MH (p<0.001) аnd VT (p<0.007) of the SF-36 are more sensitive to change of disease activity.It was found that in patients with SLE with a high activity of the disease, the noncomparable domains such as Planning (p<0.0004), Intimate relationship (p<0.003), Burden to others (p<0.03), Body image (p<0.007) significantly change. The QOL in patients with SLE with SDI ≥1 was poor in the domain of Physical health of the LupusQoL and in the comparable domain of the SF-36 PF. Higher QOL in these domains was in patients without damages. The domains Fatigue and VT are also significantly affected by the damage. So, in patients with SDII ≥1, there was a significant decrease of QOL in these domains up to 60.35±24.0 and 49.55±20.32, respectively, as compared with patients without damages 65.7±25.3 (p≤0.03) and 55.69±20.32 (p≤0.02) respectively.ConclusionLupusQoL is more sensitive to changes in SLE activity. Both SF-36 and LupusQoL are equally sensitive to changes in organ damage.Disclosure of InterestsNone declared