Zika virus, an RNA virus that can cause severe damage to the human body, has long lacked an effective drug. Scientists have discovered recently that Wulfenioidin, a plant distributed in southern China, contains a compound in its root that holds the potential to become an anti-Zika drug. Through extraction, multiple kinds of Wulfenioidin were discovered and their structures were characterized through various spectroscopic methods. However, there isnt a total synthesis pathway for Wulfenioidin. This essay focuses on Wulfenioidin F and provides a full synthesis pathway for the molecule. The route begins with the synthesis of two fragments 6-(2-bromo-6-methylphenyl)-6-methoxy-2-methylhexan-2-ol and 5-(propan-2-yl)-3-(I^5-diazynylidene)-3,4-dihydro-2H-pyran-2,4-dione, which then undergo a convergent coupling to form an eight-carbon ring. An intermolecular Diels-Alder reaction combines the benzyne and pyrone together, forming the final product and completing the total synthesis.