Hypoxia acute and chronic modulates the expression of inflammatory mediators such as cytokines. However, studies in chronic and intermittent hypobaric or normobaric hypoxia similar to described in miner’s population are scares o absent. In regards with this we propose evaluated the effect of chronic intermittent normobaric hypoxia (CINH) on the hematological, cardiovascular response and expression of lymphocyte’s cytokines such as IL-1b, IL-2, IL6 and IL-10 in rats. A total of 20 Sprague-Dawley rats were divided in two groups: a) CINH of FiO2 10% (n=10) and normoxic rats (n=10) were used as controls. Blood samples were obtained from both groups for hematological studies, systolic arterial pressure and heart rate was measured in tail-cuff sensor, and expression of cytokines obtained from lymphocytes was determined by RT-PCR. Hematocrit, hemoglobin, platelet count and hematological constant are elevated however leucocyte count decrease. A significant increase of systolic arterial pressure (over 50%). In vitro expression of cytokines from lymphocytes shown that IL-10, IL-2 and IL6 increase 35%, 64% and 16% respectively, while that of IL-1bdecreases by 18%. CINH could be activate an inflammatory response mediated by IL-2, however this response could be attenuated due to the increase in the expression of IL-10, a known anti-inflammatory cytokine, and the decrease in the expression of IL-1β and IL6 suggesting a mechanism of adaptation to CINH. Innova-Corfo Project 07CN13ISM-152. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.