Large-eddy simulation (LES) is used to simulate flow over a three-dimensional elliptical hydrofoil at 12 degrees angle of attack and Reynolds numbers (Re) of 9×105 and 1.4×106 based on root chord length and freestream velocity. The simulations are performed at the cavitation number (σ) of 2.1 and are based on the experiments of Boulon et al. (1999), who studied the tip vortex cavitation behavior under the confinement of side and bottom walls. The present simulations correspond to their case where the confinement due to the bottom wall is negligible. The computational model of Brandao and Mahesh (2022) that treats vapor as a passive scalar in an incompressible liquid is extended to account for multiple groups of bubbles of different sizes, effectively making it a polydisperse model. This allows us to investigate the effects of water quality on inception. The simulations include two different freestream nuclei distributions that are taken from the water tunnel data of Khoo et al. (2020c). It was found that inception is strongly dependent on the amounts of nuclei in the freestream. When the flow is depleted of nuclei, inception is an intermittent event confined to a location very close to the hydrofoil tip. However, when the flow is rich in nuclei, a larger portion of the tip vortex cavitates, as well as part of the suction side very close to the leading edge of the hydrofoil. Probability density functions revealed that cavitation occurs in any region experiencing a pressure field lower than vapor pressure when the flow is rich in nuclei, while extremely low values of pressure (usually kPa of tension) are required to make a flow depleted of nuclei cavitate. The topology of a flow poor in nuclei was investigated and inception was found to occur in regions dominated by irrotational straining with high stretching rates. Lagrangian statistics showed that as Re is increased, nuclei have higher likelihood of experiencing very low pressure fields. However, the amount of time they are subject to very low pressures is also shorter with increasing Re.