Abstract The aerodynamic flow field at the outlet of a high-pressure turbine (HPT) stage in a modern turbofan engine is highly unsteady and strongly influenced by periodic fluctuations from the HPT rotor, also interacting with the HPT stationary vanes. Downstream of the last HPT stage, the flow enters the intermediate turbine duct (ITD), where new unsteady components are generated, due to the interaction between the incoming flow and the struts supporting the ITD. This paper illustrates the differences between the unsteady flow behavior in two state-of-the-art ITD configurations for turbofan engines: the turbine center frame and the turbine vane frame. The experimental results discussed in this work are obtained in the Transonic Test Turbine Facility, situated at Graz University of Technology, Austria. To achieve engine-representative operating conditions at the ITD inlet and outlet sections, the tested setups include not only the duct, but also the last HPT stage and the first low-pressure turbine stage row. Additionally, the test rig features a secondary air supply system, capable of feeding purge air to every stator–rotor cavity in the test vehicle. Unsteady measurement data at the inlet and outlet of the two duct configurations are acquired with fast-response aerodynamic pressure probes, for two purge flow conditions. Azimuthal mode decomposition is applied to phase-averaged data at selected radial positions, to isolate and quantify the contribution of different interaction modes to the overall unsteady flow field.