Orthogonal frequency division multiple access (OFDMA) and single carrier frequency division multiple access (SC-FDMA) are two technologies for the uplink transmission of present and next generation of broadband wireless systems. This paper studies and compares OFDMA and SC-FDMA in terms of sensitivity to carrier frequency offset (CFO) in the uplink. In order to calculate signal-to-interference ratio (SIR), we use a simple superposition principle approach where the contributions of different users are studied separately. We derive closed-form mathematical expressions for the desired signal, interference terms, and consequently SIR for both OFDMA and SC-FDMA systems in the uplink. It is pointed out that there is a strong relationship between sensitivity analysis to CFO and subcarrier allocation schemes. Also, we prove that the derived expressions for both systems are reduced to very simple forms in interleaved subcarrier allocation. Finally, the theoretical analysis are verified using Monte Carlo simulations in block, interleaved, and block-interleaved subcarrier allocations, and the two systems are compared upon these set of results.