The Pain Resilience Scale, a recently developed measure capturing behavioral perseverance and cognitive-affectivity positivity despite pain, has been validated as a predictor of acute pain in healthy adults. However, the utility of this scale has yet to be examined in a clinical setting. Forty-nine individuals who underwent an 8-week interdisciplinary functional restoration program completed the Pain Resilience Scale and Pain Catastrophizing Scale at admission to the program, as well as the SF-36, a self-report measure of physical and mental health, at both admission and discharge. Two hierarchical linear regressions were conducted to examine predictors of self-reported physical and mental health scores at discharge from the program, respectively. SF-36 scores (physical health, mental health, and bodily pain) at admission were entered into the first block of each model, while Pain Catastrophizing and Pain Resilience were entered into the second block. Together, SF-36 scores at admission were associated with physical, F(3, 46) = 7.81, p < 0.001, R2 = 33.7, and mental health, F(3,46) = 9.99, p < 0.001, R2 = 39.5, at discharge. Addition of psychosocial predictors improved the fit of both models (physical health: ΔF(2, 44) = 21.96, p < 0.001, ΔR2 = 33.1 mental health: ΔF(2, 44) = 4.79, p = 0.01, ΔR2 = 10.8) . Controlling for other variables in each model, pain resilience was positively associated with improvements in physical (B = 4.29, p <0.001) and mental health (B = 0.32, p < 0.01). This study provides initial evidence for the utility of the Pain Resilience Scale in a treatment setting, and contributes to the growing body of literature highlighting the importance of resilience in pain treatment.