Interdisciplinary Expertise Research Articles

7.M. Round table: A new lens on loneliness: leveraging the built environment for social health

Abstract Loneliness is a global issue impacting a third of all adults, with young adults (15-25 years) disproportionately affected. Prolonged loneliness has serious consequences for mental and physical health and should be addressed as a matter of urgency. The built environment, where we live, work, and socialise, is increasingly recognised as a significant factor influencing loneliness. However, existing interventions often focus on older adults and neglect the role of the built environments in promoting connectedness across the life course. To bridge this gap, we need interdisciplinary collaboration to understand how our environments and communities can mitigate loneliness. This workshop will explore the critical intersection of place and loneliness interventions. The three panellists bring unique interdisciplinary expertise on loneliness ranging from policy to intervention implementation. These three talks (10min each) will set the stage for a dynamic discussion (30min): 1. Nina Goldman, commissioned by the World Health Organization to undertake a global overview of national loneliness policies, will present findings on how national strategies integrate place-based strategies across sectors such as housing, transportation, and urban planning. 2. Mathias Lasgaard, leading researcher on loneliness interventions, will present the innovative ‘More Together’ (MoTo) project - a multifaceted intervention addressing loneliness in both young and older adults within the Silkeborg Municipality, Denmark. This presentation will contextualize MoTo within the broader landscape of targeted loneliness interventions. 3. Eric Schoenmakers, advisor of the national loneliness action program in the Netherlands, will introduce the “I BELONG” project, an international network dedicated to understanding the relationship between public spaces, loneliness, and effective interventions for young adults in the Netherlands. Key messages • We aim to stimulate a paradigm shift in the way we address loneliness by moving beyond individual-centred solutions to develop a more holistic and community-based approach. • We need more interdisciplinary collaboration to understand how our environments and communities can mitigate loneliness. Speakers/Panelists Nina Goldman University of Manchester, Manchester, UK Mathias Lasgaard Defactum, Central Denmark Region, Aarhus, Denmark Eric Schoenmakers Fontys University of Applied Sciences, Eindhoven, Netherlands

Evidence-driven indoor air quality improvement: An innovative and interdisciplinary approach to improving indoor air quality.

Indoor air pollution is a recognized emerging threat, claiming millions of lives annually. People are constantly exposed to ambient and indoor air pollution. The latest research shows that people in developed countries spend up to 90% of their time indoors and almost 70% at home. Although impaired IAQ represents a significant health risk, it affects people differently, and specific populations are more vulnerable: children, the elderly, and people with respiratory illnesses are more sensitive to these environmental risks. Despite rather extensive research on IAQ, most of the current understanding about the subject, which includes pollution sources, indoor-outdoor relationships, and ventilation/filtration, is still quite limited, mainly because air quality monitoring in the EU is primarily focused on ambient air quality and regulatory requirements are lacking for indoor environments. Therefore, the EDIAQI project aims to improve guidelines and awareness for advancing the IAQ in Europe and beyond by allowing user-friendly access to information about indoor air pollution exposures, sources, and related risk factors. The solution proposed with EDIAQI consists of conducting a characterization of sources and routes of exposure and dispersion of chemical, biological, and emerging indoor air pollution in multiple cities in the EU. The project will deploy cost-effective/user-friendly monitoring solutions to create new knowledge on sources, exposure routes, and indoor multipollutant body burdens. The EDIAQI project brings together 18 organizations from 11 different European countries that provide interdisciplinary skills and expertise in various fields, including environmental science and technology, medicine, and toxicology, as well as policy design and public engagement.

Perspective: Food Access at Dollar Stores and Its Implications for Public Health: Report of a Workshop on Identifying Research Priorities

The rapid growth of dollar stores as retail sources of food in the United States is a phenomenon with implications for diets, nutrition, and well-being. We convened a broadly interdisciplinary group of researchers and experts from government and academia at the 2-day Food Access at Dollar Stores (FADS) workshop, held in Boston, MA in 2022. The event brought together economists, social scientists, public health researchers, and advocates to discuss the concerns and research questions raised by the growth of dollar stores and their increased role in food retail and access. In-person, moderated discussions on day 2 of the workshop generated a range of topics considered important for future research. A subsequent survey, using a modified Delphi approach, identified priority research areas. Nine research area categories emerged as a result of discussion at the FADS workshop and received prioritization from the experts: Local Community Impacts; Health and Nutrition Impacts; Policy and Programs; Systemic Issues – Racism, Poverty, and Food Access; Store Offerings and Locations; Shoppers and Customers; Employees and Employment; Corporate Distribution, Strategy, and Marketing; and Dollar Stores compared with Other Food Sources. The growth of dollar stores as food retailers remains an under-researched area of study for food access and nutrition that requires interdisciplinary expertise and collaboration to understand.

Clinical management of a ruptured intracranial aneurysm

BackgroundIntracranial hemorrhage due to a ruptured aneurysm is one of the most serious neurosurgical emergencies. The patient mostly presents with severe headaches and neurological deterioration. A rapid diagnosis and an interdisciplinary approach play a major role in the fate of these patients. The treatment can vary from endovascular to surgical and must be carefully and individually planned. Neurovascular expertise and an interdisciplinary approach are of vital importance and obligatory for the best possible outcome.MethodsIn this narrative review, we scrutinize the current literature and discuss the actual data and guidelines in order to emphasize the importance of the interdisciplinary expertise and approach in patients with ruptured intracranial aneurysm.ResultsThe current approach to patients with ruptured aneurysm is inhomogeneous and often ineffective due to internal disputes between different disciplines. Although there is plenty of literature and hard evidence to “show the way,” many still choose to base their decisions on personal experience or opinion.ConclusionsEvery ruptured brain aneurysm should be approached in an interdisciplinary manor and treated according to the current evidence and guidelines.

Developing Evidence to Support Policy: Protocol for the StrAtegic PoLicy EvIdence-Based Evaluation CeNTer (SALIENT).

All federal agencies are required to support appropriation requests with evidence and evaluation (US Public Law 115-435; the Evidence Act). The StrAtegic PoLicy EvIdence-Based Evaluation CeNTer (SALIENT) is 1 of 6 centers that help the Department of Veterans Affairs (VA) meet this requirement. Working with the existing VA evaluation structure, SALIENT evaluations will contribute to (1) optimize policies and programs for veteran populations; (2) improve outcomes regarding health, equity, cost, and provider well-being; (3) advance the science of dissemination and knowledge translation; and (4) expand the implementation and dissemination science workforce. We leverage the Lean Sprint methodology (iterative, incremental, rule-governed approach to clearly defined, and time-boxed work) and 3 cores to develop our evaluation plans collaboratively with operational partners and key stakeholders including veterans, policy experts, and clinicians. The Operations Core will work with evaluation teams to develop timelines, facilitate work, monitor progress, and guide quality improvement within SALIENT. The Methods Core will work with evaluation teams to identify the most appropriate qualitative, quantitative, and mixed methods approaches to address each evaluation, ensure that the analyses are conducted appropriately, and troubleshoot when problems with data acquisition and analysis arise. The Knowledge Translation (KT) Core will target key partners and decision makers using a needs-based market segmentation approach to ensure that needs are incorporated in the dissemination of knowledge. The KT Core will create communications briefs, playbooks, and other materials targeted at these market segments to facilitate implementation of evidence-based practices and maximize the impact of evaluation results. The SALIENT team has developed a center infrastructure to support high-priority evaluations, often to be responsive to shifting operational needs and priorities. Our team has engaged in our core missions and operations to rapidly evaluate a high-priority areas, develop a comprehensive Lean Sprint systems redesign approach to training, and accelerate rapid knowledge translation. With an array of interdisciplinary expertise, operational partnerships, and integrated resources, SALIENT has an established and evolving infrastructure to rapidly develop and implement high-impact evaluations. Projects are developed with sustained efficiency approaches that can pivot to new priorities as needed and effectively translate knowledge for key stakeholders and policy makers, while creating a learning health system infrastructure to foster the next generation of evaluation and implementation scientists. PRR1-10.2196/59830.

Understanding disciplinary perspectives: a framework to develop skills for interdisciplinary research collaborations of medical experts and engineers

BackgroundHealth professionals need to be prepared for interdisciplinary research collaborations aimed at the development and implementation of medical technology. Expertise is highly domain-specific, and learned by being immersed in professional practice. Therefore, the approaches and results from one domain are not easily understood by experts from another domain. Interdisciplinary collaboration in medical research faces not only institutional, but also cognitive and epistemological barriers. This is one of the reasons why interdisciplinary and interprofessional research collaborations are so difficult. To explain the cognitive and epistemological barriers, we introduce the concept of disciplinary perspectives. Making explicit the disciplinary perspectives of experts participating in interdisciplinary collaborations helps to clarify the specific approach of each expert, thereby improving mutual understanding.MethodWe developed a framework for making disciplinary perspectives of experts participating in an interdisciplinary research collaboration explicit. The applicability of the framework has been tested in an interdisciplinary medical research project aimed at the development and implementation of diffusion MRI for the diagnosis of kidney cancer, where the framework was applied to analyse and articulate the disciplinary perspectives of the experts involved.ResultsWe propose a general framework, in the form of a series of questions, based on new insights from the philosophy of science into the epistemology of interdisciplinary research. We explain these philosophical underpinnings in order to clarify the cognitive and epistemological barriers of interdisciplinary research collaborations. In addition, we present a detailed example of the use of the framework in a concrete interdisciplinary research project aimed at developing a diagnostic technology. This case study demonstrates the applicability of the framework in interdisciplinary research projects.ConclusionInterdisciplinary research collaborations can be facilitated by a better understanding of how an expert’s disciplinary perspectives enables and guides their specific approach to a problem. Implicit disciplinary perspectives can and should be made explicit in a systematic manner, for which we propose a framework that can be used by disciplinary experts participating in interdisciplinary research project. Furthermore, we suggest that educators can explore how the framework and philosophical underpinning can be implemented in HPE to support the development of students’ interdisciplinary expertise.

Communication Strategies for Interdisciplinary Collaboration: Bridging complex expertise

For consulting agencies, service design projects often face tight timelines, requiring rapid adaptation to clients' complex industries. Effective collaboration is crucial, especially in supply chain planning and healthcare logistics. How can strategic communication and interdisciplinary collaboration help leverage client expertise and achieve meaningful outcomes?

Privacy‐preserving collaboration in blockchain‐enabled IoT: The synergy of modified homomorphic encryption and federated learning

SummaryThe proliferation of network devices capable of gathering, transmitting, and receiving data over the Internet has spurred the widespread adoption of Internet of Things (IoT) devices, particularly in resource‐oriented applications. Integrating blockchain, IoT, homomorphic encryption, and federated learning requires a balance between computational requirements and real‐time performance. Secure key management is crucial to maintain data privacy and integrity. Compliance with privacy regulations requires careful implementation of privacy‐preserving mechanisms in blockchain‐enabled IoT environments, which can be subjected to various attacks. Addressing these challenges requires interdisciplinary expertise, research, and innovation to develop more efficient and effective privacy‐preserving techniques tailored to the unique characteristics of such environments. This research introduces the Modified Homomorphic Encryption Federated‐based Adaptive Hybrid Dandelion Search (MHEF‐AHDS) algorithm as an effective framework to enhance security in blockchain‐enabled IoT systems. The amalgamation of Modified Homomorphic Encryption (MHE) and Federated Learning (FL) constitutes a potent alliance that addresses privacy concerns within collaborative and decentralized machine learning environments. This facilitates secure and adaptable data collaboration, effectively mitigating privacy risks associated with sensitive information. The integration of quantum machine learning into security applications presents an exciting opportunity for distinctive progress and innovation. Within this work, the Adaptive Hybrid Dandelion optimization algorithm, featuring an Initial search strategy, is employed for hyperparameter optimization thereby elevating the performances of the proposed MHEF‐AHDS method. Furthermore, the integration of smart contracts and Blockchain‐based IoT enhances the overall security of the proposed method. MHEF‐AHDS comprehensively tackles privacy, security, and scalability challenges through robust security measures and privacy enhancements. The performance evaluation of the MHEF‐AHDS method encompasses a thorough analysis based on key metrics such as throughput, latency, scalability, energy consumption, accuracy, precision, recall, and f1‐score. Comparative assessments against existing methods are conducted to gauge the effectiveness of the proposed method in addressing security, privacy, and scalability concerns.

Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients-it takes a village.

People use dietary supplements to offset nutritional deficiencies and manage metabolic dysfunction. While the beneficial effect of fish proteins on glucose homeostasis is well established, the ability of fish peptides to replicate the protein findings is less clear. With financial support from a programmatic Canadian Institutes of Health Research (CIHR) Team grant, we aimed to identify salmon peptide fractions (SPFs) with the potential to mitigate metabolic dysfunction. Additionally, the grant aims included assessing whether vitamin D, a nutrient commonly found in salmon, could potentiate the beneficial effects of salmon peptides. In parallel, technologies were developed to separate and filter the isolated peptides. We employed an integrative approach that combined nutritional interventions in animal models and human subjects to identify metabolic pathways regulated by salmon peptides and other fish nutrients. This combination of interdisciplinary expertise revealed that a SPF could be a therapeutic tool used in the prevention and management of cardiometabolic diseases. Herein, we present a perspective of our CIHR funded grant that utilized a translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients: from animal models to clinical trials.

Models and Outcomes of Multidisciplinary Clinics in Colorectal Cancer.

Multidisciplinary clinics (MDCs) represent a potential platform through which high-quality, patient-centered care grounded in interdisciplinary expertise may be delivered for patients with colorectal cancer (CRC). This is increasingly important with the rapidly emerging diagnostic and treatment modalities as well as differential sequences of therapies available. MDCs have been reported to improve various outcomes across numerous non-colorectal cancers; however, data specific to the use of MDCs in CRC are more limited. In this report, we provide a narrative review of the different models of CRC MDCs in the literature and their associations with cancer care outcomes. We found significant heterogeneity in MDC operational logistics as well as reported outcomes across different practice settings. Further research is needed to better understand how MDCs may be optimally structured to meet the unique needs of patients with CRC and how they may affect CRC outcomes.

Logistics and Interdisciplinary Expertise of a Sexual Assault Response Team: A Case Study Through Observations and Interviews.

To more effectively respond to sexual assault in the United States, some jurisdictions have created sexual assault response teams (SARTs). SARTs involve members of multiple agencies tasked with responding to sexual assault within a jurisdiction, such as law enforcement, advocates, prosecutors, and sexual assault nurse examiners (SANEs). Despite hundreds of jurisdictions utilizing SARTs, and the Department of Justice establishing guidelines, SARTs vary across jurisdictions in their form and function. To clarify this, the current research outlines two studies to better understand the logistics and functioning of one SART. In Study 1, for over nearly 2 years, SART meetings were observed and notes were taken on representation of agencies, time spent on cases, and possible challenges. Overall, the SART met consistently, with representation of major stakeholders at each meeting. Stakeholder agencies remained consistent and most time spent in the meetings was on case review. In Study 2, 10 members of SART were interviewed to assess perceptions of SART. These interviews were independently qualitatively coded for both factual and thematic codes. Areas of focus included perceived logistics of the SART and expertise of members that make up an effective SART. Overall, on average, members had been part of the SART for 3.5 years, felt required to attend the meetings as part of their role, and shared that all members (i.e., law enforcement, district attorney, victim advocates, and SANEs) had expertise on differing subjects that effectively made the SART work well. Importantly, qualitative perceptions from members of the SART (Study 2) lined up with the independent observation of SART meetings (Study 1). Ultimately, the results from this body of research could delineate specific actions that a jurisdiction implementing a SART could utilize.

Microscopic and Molecular Diagnosis of Cryptosporidium spp. in Human in Babylon Province, Iraq

Background: Considering the importance of Cryptosporidium spp. to public health and the country's economic situation due to the threat of an outbreak and economic losses. Objectives: this study aimed to detect Cryptosporidium spp. in human in Babylon province using traditional and molecular techniques. Methods: this study was conducted in Babylon province from September, 2023 to March, 2024.a total of 100 human stool samples were examined microscopically for detection of Cryptosporidium spp. from both diarrheal and non-diarrheal patients attend hospitals and public health centers laboratories. Results: by using microscopic examination. The rate of infection with Cryptosporidium spp. was (25/100), 25%. According to sex, the highest infection rate in humans was in males (17/59),28.81% compared to females (8/41) ,19,51%. was recorded in the rate of infection between age groups, the highest rate (13/28), 46.42% observed in < 5years of human. Rural area revealed the highest rate of infection than urban area in human (16/44),36.63%. In molecular diagnosis, DNA extraction was performed for 50 stool samples human 28% (14/50) C hominis 10% (5/50) C parvum 18% (9/50) by nested PCR, in order to investigate the genotypes of Cryptosporidium spp. from human in Babylon, five Cryptosporidium spp. isolates. were genetically characterized by SSU-rDNA gene sequencing. The results showed C parvum (1/5) C hominis (4/5). Conclusion: these findings suggested that infection of humans by zoonotic genotypes were the most common genotypes detected in all human samples in Babylon province, to enhance the effectiveness of the One Health approach in preventing Cryptosporidium spp. infection, it is crucial to have a deeper understanding of the environmental, epidemiological, and etiological aspects linked to Cryptosporidium infection. This knowledge will aid in the development of more effective risk management strategies. The future One Health plan seeks to incorporate diverse and interdisciplinary expertise.

A proposed framework for data-driven human factors evaluation

AbstractHuman-centred approaches within the design cycle are crucial to enhance usability and inclusivity of products. However, the qualitative nature of traditional human factors evaluation can create bottle necks, prompting the need for more data driven methods. A framework for data-driven human factors is presented, looking to integrate mixed-method approaches. Case studies illustrate its usage in real-world scenarios and challenges are summarised, calling for robust data collection methods, balancing of mixed methods, a need for explainable systems, and interdisciplinary expertise.

Psychological aspects of vestibular disorders: a national survey of clinical practice.

This study examines how psychological aspects of vestibular disorders are currently addressed highlighting any national variation. An online survey was completed by 101 UK healthcare professionals treating vestibular disorders. The survey covered service configurations, attitudes towards psychological aspects and current clinical practice. Ninety-six per cent of respondents thought there was a psychological component to vestibular disorders. There was a discrepancy between perceived importance of addressing psychological aspects and low confidence to undertake this. Those with more experience felt more confident addressing psychological aspects. History taking and questionnaires containing one or two psychological items were the most common assessment approaches. Discussing symptoms and signposting were the most frequent management approaches. Qualitative responses highlighted the interdependence of psychological and vestibular disorders which require timely intervention. Barriers included limited referral pathways, resources and interdisciplinary expertise. Although psychological distress is frequently identified, suitable psychological treatment is not routinely offered in the UK.

Conservation museomics.

Article Impact Statement: Conservation museomics leverages natural history collections and interdisciplinary expertise to advance conservation science and innovation This article is protected by copyright. All rights reserved.

Machine Learning Models and Technologies for Evidence-Based Telehealth and Smart Care: A Review

Background: Over the past few years, clinical studies have utilized machine learning in telehealth and smart care for disease management, self-management, and managing health issues like pulmonary diseases, heart failure, diabetes screening, and intraoperative risks. However, a systematic review of machine learning’s use in evidence-based telehealth and smart care is lacking, as evidence-based practice aims to eliminate biases and subjective opinions. Methods: The author conducted a mixed methods review to explore machine learning applications in evidence-based telehealth and smart care. A systematic search of the literature was performed during 16 June 2023–27 June 2023 in Google Scholar, PubMed, and the clinical registry platform ClinicalTrials.gov. The author included articles in the review if they were implemented by evidence-based health informatics and concerned with telehealth and smart care technologies. Results: The author identifies 18 key studies (17 clinical trials) from 175 citations found in internet databases and categorizes them using problem-specific groupings, medical/health domains, machine learning models, algorithms, and techniques. Conclusions: Machine learning combined with the application of evidence-based practices in healthcare can enhance telehealth and smart care strategies by improving quality of personalized care, early detection of health-related problems, patient quality of life, patient-physician communication, resource efficiency and cost-effectiveness. However, this requires interdisciplinary expertise and collaboration among stakeholders, including clinicians, informaticians, and policymakers. Therefore, further research using clinicall studies, systematic reviews, analyses, and meta-analyses is required to fully exploit the potential of machine learning in this area.

Recommendations for optimal interdisciplinary management and healthcare settings for patients with rare neurological diseases

BackgroundIn 2017, the German Academy for Rare Neurological Diseases (Deutsche Akademie für Seltene Neurologische Erkrankungen; DASNE) was founded to pave the way for an optimized personalized management of patients with rare neurological diseases (RND) in all age groups. Since then a dynamic national network for rare neurological disorders has been established comprising renowned experts in neurology, pediatric neurology, (neuro-) genetics and neuroradiology. DASNE has successfully implemented case presentations and multidisciplinary discussions both at yearly symposia and monthly virtual case conferences, as well as further educational activities covering a broad spectrum of interdisciplinary expertise associated with RND. Here, we present recommendation statements for optimized personalized management of patients with RND, which have been developed and reviewed in a structured Delphi process by a group of experts.MethodsAn interdisciplinary group of 37 RND experts comprising DASNE experts, patient representatives, as well as healthcare professionals and managers was involved in the Delphi process. First, an online collection was performed of topics considered relevant for optimal patient care by the expert group. Second, a two-step Delphi process was carried out to rank the importance of the selected topics. Small interdisciplinary working groups then drafted recommendations. In two consensus meetings and one online review round these recommendations were finally consented.Results38 statements were consented and grouped into 11 topics: health care structure, core neurological expertise and core mission, interdisciplinary team composition, diagnostics, continuous care and therapy development, case conferences, exchange / cooperation between Centers for Rare Diseases and other healthcare partners, patient advocacy group, databases, translation and health policy.ConclusionsThis German interdisciplinary Delphi expert panel developed consented recommendations for optimal care of patients with RND in a structured Delphi process. These represent a basis for further developments and adjustments in the health care system to improve care for patients with RND and their families.

Can Online Music Platforms Be Fair? An Interdisciplinary Research Manifesto

In this article we present a manifesto for research into the complex interplay between social media, music streaming services, and their algorithms, which are reshaping the European music industry – a sector that has transitioned from ownership to access-based models. Our focus is to assess whether the current digital economy supports a fair and sustainable development for cultural and creative industries. The manifesto is designed to pave the way for a comprehensive analysis. We begin with the context of our research by briefly examining the de-materialisation of the music industry and the critical role of proprietary algorithms in organising and ranking creative works. We then scrutinise the notion of “fairness” within digital markets, a concept that is attracting increasing policy interest in the EU. We believe that, for “fairness” to be effective, the main inquiry around this concept – especially as regards remuneration of music creators – must be necessarily interdisciplinary. This presupposes collaboration across complementary fields to address gaps and inconsistencies in the understanding of how these platforms influence music creation and consumption and whether these environments and technologies should be regulated. We outline how interdisciplinary expertise (political science, law, economics, and computer science) can enhance the current understanding of “fairness” within Europe’s cultural policies and help address policy challenges. The article details how our research plan will unfold across various disciplinary hubs of a Horizon Europe project (Fair MusE) that aims to explore the challenges and opportunities of today’s digital music landscape. The plan culminates in the integration of these hubs’ findings to deliver “key exploitable results”.

Role of recombinant factor VIIa in the clinical management of severe postpartum hemorrhage: consensus among European experts

Objectives There have been significant advances in the medical management of severe postpartum hemorrhage (sPPH) over recent decades, which is reflected in numerous published guidelines. To date, many of the currently available national and international guidelines recommend recombinant factor VIIa (rFVIIa) to be used only at a very late stage in the course of sPPH, as a “last resort”, before or after hysterectomy. Based on new safety data, rFVIIa has recently been approved by the European Medicines Agency (EMA) and Swissmedic for use in sPPH, if uterotonics are insufficient to achieve hemostasis, which in fact is significantly earlier in the course of postpartum hemorrhage (PPH). We therefore aimed to develop expert consensus guidance as a step toward standardizing care with the use of rFVIIa for clinicians managing women experiencing life-threatening sPPH. Methods The consensus process consisted of one face-to-face meeting with a group of nine experts, including eight obstetrician-gynecologists and a hematologist highly experienced in sPPH care in tertiary care perinatal centers. The panel was representative of multidisciplinary expertise in the European obstetrics community and provided consensus opinion in answer to pre-defined questions around clinical practice with rFVIIa in the management of sPPH. Recommendations have been based on current national and international guidelines, extensive clinical experience, and consensus opinion, as well as the availability of efficacy and new safety data. Results The expert panel developed 17 consensus statements in response to the 13 pre-defined questions on the use of rFVIIa in the management of sPPH including: available efficacy and safety data and the need for interdisciplinary expertise between obstetricians, anesthesiologists, and hematologists in the management of sPPH. Based on novel data, the experts recommend: (1) earlier administration of rFVIIa in patients with sPPH who do not respond to uterotonic administration to optimize the efficacy of rFVIIa; (2) the importance of hematological parameter prerequisites prior to the administration of rFVIIa to maximize efficacy; and (3) continued evaluation or initiation of further invasive procedures according to standard practice. Furthermore, recommendations on the timing of rFVIIa treatment within the sPPH management algorithm are outlined in a range of specified clinical scenarios and settings, including vaginal delivery, cesarean section, and smaller birthing units before transfer to a tertiary care center. The panel agreed that according to available, and new data, as well as real-world experience, there is no evidence that the use of rFVIIa in patients with sPPH increases the risk of thromboembolism. The authors acknowledge that there is still limited clinical effectiveness data, as well as pharmacoeconomic data, on the use of rFVIIa in sPPH, and recommend further clinical trials and efficacy investigation. Conclusions This expert panel provides consensus guidance based on recently available data, clinical experience, and expert opinion, augmented by the recent approval of rFVIIa for use in sPPH by the EMA. These consensus statements are intended to support clinical care for sPPH and may help to provide the impetus and a starting point for updates to existing clinical practice guidelines.

An Efficient Summarisation and Search Tool for Research Articles

Building an efficient summarization and search tool for research articles is a complex task that involves interdisciplinary expertise in NLP, database management, web development, and user experience design. With the rapid growth of the scientific content, manually reading and selecting important content of research articles became challenging. Thus, there is a need for a summarization tool to help scholars reading their content fast along with a search tool that will find important contents and keep them in organized way. To summarize the contents of different articles a summarization tool is proposed in this work that generates extractive and abstractive summaries. Along with summarization a search engine also been proposed in this work that save the searched results in a comma-separated value (CSV) format including the search queries and meta information of articles such as keyword, title, author name, URL, year of publication, abstracts and summaries. These CSVs help users to get idea about article contents in offline mode without reading or searching the whole text. The efficiency of the summarizer tool is evaluated in terms of precision(pr), recall(re) and F-measure(F-m) of Rouge-1(R1), Rouge-2(R2), Rouge_sum(R_sum) and Bertscore(BS) measures for ten research articles. The average pr, re and F-m obtained from BS are 42%, 42% and 42% for extractive summarization and 41%, 41% and 41% for abstractive summarization. This tool will be helpful to research scholars in the collection of literature and the preparation of related work for their research.