This article argues that many methodological approaches used in intercultural technical communication research are limited in addressing emerging social justice challenges in many post-colonial, developing, and unenfranchised/disenfranchised cultural sites, where professional communicators have begun conducting research. It offers decolonial approaches as an alternative by highlighting how these approaches are used in an intercultural research that investigates attempts to localize communication that accompanies sexuo-pharmaceuticals from one cultural context to another. The article also discusses some the challenges and benefits of such approaches.The ways in which scientific research is implicated in the worst excesses of colonialism remain a powerfully remembered history for many of the world's colonized peoples. It is a history that still offends the deepest sense of our humanity [1, p. 1].Global research raises many methodological and ethical challenges for technical communicators … because of the cross-cultural, international, and transnational nature of the work [2, p. 283].