The locally twisted cube LTQn is a variant of the hypercube Qn, which was introduced by Yang et al. (2005) as an interconnection network for parallel computing. The symmetry of Qn is well-known, for example, it is an edge-transitive Cayley graph. However, the symmetry of LTQn remains unclear. In this paper, we first prove that LTQn with n≥4 is isomorphic to a bi-Cayley graph of an elementary abelian 2-group Z2n−1 of order 2n−1, and then prove that the full automorphism group of LTQn with n≥4 is isomorphic to Z2n−1. These show that LTQn with n≥4 is not edge-transitive, and its full automorphism group has exactly two orbits on the vertex set of LTQn (and consequently it is not vertex-transitive and not a Cayley graph). What is more, the symmetry of LTQn with n≥4 also implies that it can be decomposed to two vertex-disjoint (n−1)-dimensional hypercubes and a perfect matching. As an application, we obtain the k-extra connectivity and (k+1)-component connectivity with k≤n−1 of LTQn, which generalize some previous works.
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