A new one-dimensional model is presented for the calculation of steady and unsteady flow through an indented two-dimensional channel with separation and reattachment. It is based on an interactive boundary layer approach, where the equations for the boundary layer flow near the channel walls and for an inviscid core flow are solved simultaneously. This approach requires no semi-empirical inputs, such as the location of separation and reattachment, which is an advantage over other existing one-dimensional models. Because of the need of an inviscid core alongside the boundary layers, the type of inflow as well as the length of the channel and the value of the Reynolds number poses some limitations on the use of the new model. Results have been obtained for steady flow through the indented channel of Ikeda and Matsuzaki. In further perspective, it is discussed how the present model, in contrast to other one-dimensional flow models, can be extended to calculate the flow in nonsymmetrical channels, by considering different boundary layers on each of the walls.