The present study aimed at designing a structural equation model of the effect of technology commercialization performance on creating sustainable competitive advantage of knowledgeable companies with an emphasis on the moderating environmental factors.Research population includes 133 managers of knowledge based companies at the center for the growth and development of science and technology Park of East Azerbaijan University and based on the Cochran formula, the sample size was measured to be 99, and selection by stratified random sampling method, and the standard questionnaire is distributed among them. The research is applied in nature and the method is descriptive and survey. Then, the data were analyzed using smart pls software for partial least squares (PLS) path modeling. The results show that the technology commercialization performance has a positive effect on the competitive sustainable advantage of knowledge-based companies, as well as the role of variable moderating environmental factors (market turbulence, competitive intensity and technological turbulence) in the path between the technology commercialization performance and the sustainable competitive advantage of knowledge-based companies.