This study constructs a configurational framework to examine the complex relationships of factors influencing firms' mechanisms in intellectual property (IP) protection within the dichotomy of open and closed innovation models. Our methodology synthesizes an extensive literature review to identify and explicate four configurations of intellectual property and innovation strategies: open/formal, open/informal, closed/formal, and closed/informal. These configurations reflect the multifaceted decision-making firms face in aligning their innovation models with suitable IP mechanisms. By integrating factors such as industry sector, innovation nature, market dynamics, and legal context, we offer a comprehensive framework that captures the strategic considerations of intellectual property management, highlighting the importance of various factors in shaping firms' protection and innovation decisions. Our findings propose a nuanced understanding of IP strategy selection, setting the stage for future empirical investigations to test and refine this framework across diverse industries and markets.