Spherical needlets were introduced by Narcowich, Petrushev, and Ward to provide a multiresolution sequence of polynomial approximations to functions on the sphere. The needlet construction makes use of integration rules that are exact for polynomials up to a given degree. The aim of the present paper is to relax the exactness of the integration rules by replacing them with QMC designs as introduced by Brauchart, Saff, Sloan, and Womersley (2014). Such integration rules (generalised here by allowing non-equal cubature weights) provide the same asymptotic order of convergence as exact rules for Sobolev spaces Hs, but are easier to obtain numerically. With such rules we construct “generalised needlets”. The paper provides an error analysis that allows the replacement of the original needlets by generalised needlets, and more generally, analyses a hybrid scheme in which the needlets for the lower levels are of the traditional kind, whereas the new generalised needlets are used for some number of higher levels. Numerical experiments complete the paper.