To solve the problem of low broadband multi-directional vibration control of fluid-conveying pipes, a novel metamaterial periodic structure with multi-directional wide bandgaps is proposed. First, an integrated design method is proposed for the longitudinal and transverse wave control of fluid-conveying pipes, and a novel periodic structure unit model is constructed for vibration reduction. Based on the bandgap vibration reduction mechanism of the acoustic metamaterial periodic structure, the material parameters, structural parameters, and the arrangement interval of the periodic structure unit are optimized. The finite element method (FEM) is used to predict the vibration transmission characteristics of the fluid-conveying pipe installed with the vibration reduction periodic structure. Then, the wave/spectrum element method (WSEM) and experimental test are used to verify the calculated results above. Lastly, the vibration attenuation characteristics of the structure under different conditions, such as rubber material parameters, mass ring material, and fluid-structure coupling effect, are analyzed. The results show that the structure can produce a complete bandgap of 46 Hz–75 Hz in the low-frequency band below 100 Hz, which can effectively suppress the low broadband vibration of the fluid-conveying pipe. In addition, a high damping rubber material is used in the design of the periodic structure unit, which realizes the effective suppression of each formant peak of the pipe, and improves the vibration reduction effect of the fluid-conveying pipe. Meanwhile, the structure has the effect of suppressing both bending vibration and longitudinal vibration, and effectively inhibits the transmission of transverse waves and longitudinal waves in the pipe. The research results provide a reference for the application of acoustic metamaterials in the multi-directional vibration control of fluid-conveying pipes.